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Full-Text Articles in Life Sciences

An Intersectional Feminist Approach To Lyme Disease Epidemiology, Meghan Frisard Apr 2019

An Intersectional Feminist Approach To Lyme Disease Epidemiology, Meghan Frisard

Honors College

Nationally, Maine is the state with the second highest incidence of Lyme disease. While the spread of Lyme disease is generally attributable to ecological factors that affect the life cycle of Lyme-spreading ticks, socioeconomic factors may have substantial impacts on diagnosis and reporting of human cases. Socioeconomic factors could influence one’s ability to see a healthcare provider and ultimately be diagnosed with and treated for Lyme. Additionally, access to and treatment within the healthcare system is often gendered. I hypothesize that certain socioeconomic factors will have a negative correlation with Lyme disease incidence among the general population and among ...


The Most Critical Resource: How Climate Change Fuels The Crisis In Syria And The Implications For The World At Large, Edward Medeiros Apr 2019

The Most Critical Resource: How Climate Change Fuels The Crisis In Syria And The Implications For The World At Large, Edward Medeiros

Honors College

The Syrian crisis, both domestic and international in scope, may well be the defining geopolitical challenge of the generation. Climate change may be the single greatest challenge to face humanity in the entirety of our species’ life history. The dramatic effects of climate change can be seen in the origins of the Syrian crisis when one looks to humanity’s single most critical resource: water. We take the word critical to have two meanings in this context: first, that water is essential to human survival and second that water is a resource in critical condition. Syria’s water crisis pre-dates ...


Construction Of A Cpsa Double Mutant To Determine The Function Of The Lyt-R Domain, Klarissa Klier Apr 2019

Construction Of A Cpsa Double Mutant To Determine The Function Of The Lyt-R Domain, Klarissa Klier

Honors College

Streptococcus agalactiae, otherwise known as Group B Streptococcus (GBS), is a zoonotic, Gram-positive, commensal and invasive bacteria which is the leading cause of neonatal bacterial infections. These bacterial infections include sepsis, meningitis, pneumonia, and bacteremia. In neonates, GBS is most commonly transferred to the child in utero or during birth when the child aspirates amniotic or vaginal fluids. GBS can also infect the child through the bloodstream while in utero, causing premature births or still births. Children who survive the initial infection develop severe morbidities which include mental retardation, cerebral palsy, and seizures. GBS can also affect immunocompromised adults, leading ...


Mmp13 Inhibition Does Not Rescue Gmppb-Deficient Skeletal Muscle In Zebrafish, Sean Driscoll Apr 2019

Mmp13 Inhibition Does Not Rescue Gmppb-Deficient Skeletal Muscle In Zebrafish, Sean Driscoll

Honors College

The dystroglycan protein is one of many that attach skeletal muscle fibers to the basement membrane at the myotendinous junction. In the alpha-subunit of the dystroglycan molecule, there are sugar chains that help with the adhesion of the molecule to the basement membrane. A mutation in any gene that codes for an enzyme that adds these sugar chains can result in a form of congenital muscle disease called secondary dystroglycanopathy. One of the genes that codes for an enzyme that adds sugar chains is GMPPB and a mutation in this gene results in GMPPB-associated dystroglycanopathy. Using zebrafish as a model ...