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Full-Text Articles in Life Sciences

Dissecting Trait Heterogeneity: A Comparison Of Three Clustering Methods Applied To Genotypic Data, Tricia A. Thornton-Wells, Jason H. Moore, Jonathan L. Haines Apr 2006

Dissecting Trait Heterogeneity: A Comparison Of Three Clustering Methods Applied To Genotypic Data, Tricia A. Thornton-Wells, Jason H. Moore, Jonathan L. Haines

Open Dartmouth: Peer-reviewed articles by Dartmouth faculty

Background: Trait heterogeneity, which exists when a trait has been defined with insufficient specificity such that it is actually two or more distinct traits, has been implicated as a confounding factor in traditional statistical genetics of complex hu man disease. In the absence of de tailed phenotypic data collected consistently in combination with genetic data, unsupervised computational methodologies offer the potential for discovering underlying trait heteroge neity. The performance of three such methods – Bayesian Classification, Hyperg raph-Based Clustering, and Fuzzy k -Modes Clustering – appropriate for categorical data were comp ared. Also tested was the ability of these methods to detect ...


Genome-Wide Linkage Analysis To Identify Chromosomal Regions Affecting Phenotypic Traits In The Chicken. I. Growth And Average Daily Gain, H. Zhou, Nader Deeb, C. M. Evock-Clover, C. M. Ashwell, Susan J. Lamont Jan 2006

Genome-Wide Linkage Analysis To Identify Chromosomal Regions Affecting Phenotypic Traits In The Chicken. I. Growth And Average Daily Gain, H. Zhou, Nader Deeb, C. M. Evock-Clover, C. M. Ashwell, Susan J. Lamont

Animal Science Publications

Two informative chicken F2 populations based on crosses between a broiler breeder male line and dams from genetically distinct, highly inbred (>99%) chicken lines, the Leghorn G-B2 and Fayoumi M15.2, have been used for genome-wide linkage and QTL analysis. Phenotypic data on 12 body composition traits (breast muscle weight, breast muscle weight percentage, abdominal fat weight, abdominal fat weight percentage, heart weight, heart weight percentage, liver weight, liver weight percentage, spleen weight, spleen weight percentage, and drumstick weight, and drumstick weight percentage) were collected. Birds were genotyped for 269 microsatellite markers across the genome. The QTL Express program ...