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Life Sciences Commons

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2006

Selected Works

University of Massachusetts - Amherst

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Full-Text Articles in Life Sciences

A Comprehensive Structure–Function Analysis Of Arabidopsis Sni1 Defines Essential Regions And Transcriptional Repressor Activity, Rebecca Mosher, Wendy Durrant, Dong Wang, Jungi Song, Xinnian Dong Jul 2006

A Comprehensive Structure–Function Analysis Of Arabidopsis Sni1 Defines Essential Regions And Transcriptional Repressor Activity, Rebecca Mosher, Wendy Durrant, Dong Wang, Jungi Song, Xinnian Dong

Dong Wang

The expression of systemic acquired resistance (SAR) in plants involves the upregulation of many Pathogenesis-Related (PR) genes, which work in concert to confer resistance to a broad spectrum of pathogens. Because SAR is a costly process, SAR-associated transcription must be tightly regulated. Arabidopsis thaliana SNI1 (for Suppressor of NPR1, Inducible) is a negative regulator of SAR required to dampen the basal expression of PR genes. Whole genome transcriptional profiling showed that in the sni1 mutant, Nonexpresser of PR genes (NPR1)–dependent benzothiadiazole S-methylester–responsive genes were specifically derepressed. Interestingly, SNI1 also repressed transcription when expressed in yeast, suggesting that it ...