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2006

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Articles 1 - 30 of 66

Full-Text Articles in Life Sciences

Aflatoxicosis In Dogs And Dealing With Suspected Contaminated Commercial Foods, Katherine Stenske, J Smith, Shelley Newman, L Newman, Claudia Kirk Jan 2015

Aflatoxicosis In Dogs And Dealing With Suspected Contaminated Commercial Foods, Katherine Stenske, J Smith, Shelley Newman, L Newman, Claudia Kirk

Shelley Newman

No abstract provided.


Calpain Inhibitor Mdl28170 Modulates Abeta Formation By Inhibiting The Formation Of Intermediate Abeta46 And Protecting Abeta From Degradation, Y Dong, J Tan, Mei-Zhen Cui, G Zhao, G Mao, N Singh, Xuemin Xu Jun 2013

Calpain Inhibitor Mdl28170 Modulates Abeta Formation By Inhibiting The Formation Of Intermediate Abeta46 And Protecting Abeta From Degradation, Y Dong, J Tan, Mei-Zhen Cui, G Zhao, G Mao, N Singh, Xuemin Xu

Mei-Zhen Cui

The observations that three major cleavages within the transmembrane domain of APP, namely, the gamma-cleavage, -cleavage, and the newly identified zeta-cleavage, are involved in the generation of secreted Abeta40 and Abeta42 prompted us to determine how the calpain inhibitor III MDL 28170 influences these three cleavages and Abeta formation. With the use of a cell culture system, our data demonstrate that 1) at either high concentrations, or at a low range of concentrations, at early time points, MDL 28170 inhibits the formation of secreted Abeta40 and Abeta42. However, this effect is due to inhibition of the intermediate Abeta46 generation by ...


Analysis Of Genetic Mutations In The 7a7b Open Reading Frame Of Coronavirus Of Cheetahs (Acinonyx Jubatus), Melissa Kennedy, E Moore, R Wilkes, S Citino, Stephen Kania Jan 2012

Analysis Of Genetic Mutations In The 7a7b Open Reading Frame Of Coronavirus Of Cheetahs (Acinonyx Jubatus), Melissa Kennedy, E Moore, R Wilkes, S Citino, Stephen Kania

Melissa A. Kennedy

OBJECTIVE: To analyze the 7a7b genes of the feline coronavirus (FCoV) of cheetahs, which are believed to play a role in virulence of this virus. SAMPLE POPULATION: Biologic samples collected during a 4-year period from 5 cheetahs at the same institution and at 1 time point from 4 cheetahs at different institutions. PROCEDURES: Samples were first screened for FCoV via a reverse transcription-PCR procedure involving primers that encompassed the 3'-untranslated region. Samples that yielded positive assay results were analyzed by use of primers that targeted the 7a7b open reading frames. The nucleotide sequences of the 7a7b amplification products were ...


Pulmonary Fibroblasts Stimulate The Proliferation Of Cell Lines From Human Lung Adenocarcinomas, Maria Cekanova, T Masi, Howard Plummer, M Majidi, P Fedorocko, Hildegard Schuller Aug 2011

Pulmonary Fibroblasts Stimulate The Proliferation Of Cell Lines From Human Lung Adenocarcinomas, Maria Cekanova, T Masi, Howard Plummer, M Majidi, P Fedorocko, Hildegard Schuller

Howard K. Plummer III

Human lung cancer cell lines are widely used to test anticancer drugs. These in-vitro tests, however, preclude the detection of responses to paracrine factors from surrounding stroma. We have cocultured pulmonary fibroblasts CCD-19Lu, from a healthy donor, or HLF-A, from a patient with epidermoid carcinoma of the lung, with two human pulmonary adenocarcinoma cell lines to test the hypothesis that the fibroblasts stimulate the growth of the tumor cells. Both fibroblast cell lines significantly increased the proliferation of the pulmonary adenocarcinoma cell lines in 3-(4,5-dimethylthiazol-2yl)-2,5-diphenyl tetrazolium bromide assays, with HLF-A fibroblasts yielding the most pronounced responses ...


Evaluation Of Canine Serum For The Presence Of Anti-Retinal Antibodies In Sudden Acquired Retinal Dengeneration Syndrome, R Keller, Stephen Kania, Diane Hendrix, Daniel Ward, K Abrams May 2011

Evaluation Of Canine Serum For The Presence Of Anti-Retinal Antibodies In Sudden Acquired Retinal Dengeneration Syndrome, R Keller, Stephen Kania, Diane Hendrix, Daniel Ward, K Abrams

Diane Hendrix

Objective: To determine the presence of serum antiretinal antibodies in sudden acquired retinal degeneration syndrome (SARDS) affected dogs and the size of the antigen to which these antibodies bind via the use of enzyme-linked immunosorbent assay (ELISA) and Western blot immunoassays. Animals studied: Serum was collected from 13 dogs affected by SARDS and five dogs with normal ocular examinations. Procedures: All serum samples were subjected to ELISA with saline-soluble canine retinal tissue and Western blot analyses with SDS solubilized normal canine retinal tissue as the antigen. Antirecoverin (23 kDa) and antiheat shock cognate (65 kDa) antibodies were used as positive ...


Evaluation Of Canine Serum For The Presence Of Anti-Retinal Antibodies In Sudden Acquired Retinal Dengeneration Syndrome, R Keller, Stephen Kania, Diane Hendrix, Daniel Ward, K Abrams Feb 2011

Evaluation Of Canine Serum For The Presence Of Anti-Retinal Antibodies In Sudden Acquired Retinal Dengeneration Syndrome, R Keller, Stephen Kania, Diane Hendrix, Daniel Ward, K Abrams

Daniel A. Ward

Objective: To determine the presence of serum antiretinal antibodies in sudden acquired retinal degeneration syndrome (SARDS) affected dogs and the size of the antigen to which these antibodies bind via the use of enzyme-linked immunosorbent assay (ELISA) and Western blot immunoassays. Animals studied: Serum was collected from 13 dogs affected by SARDS and five dogs with normal ocular examinations. Procedures: All serum samples were subjected to ELISA with saline-soluble canine retinal tissue and Western blot analyses with SDS solubilized normal canine retinal tissue as the antigen. Antirecoverin (23 kDa) and antiheat shock cognate (65 kDa) antibodies were used as positive ...


Organochlorine Levels In Seawater And Sediment From The Florida Gulf Coast, If Present, Are Low. , Richard B. Philp Nov 2006

Organochlorine Levels In Seawater And Sediment From The Florida Gulf Coast, If Present, Are Low. , Richard B. Philp

Richard B. Philp

Seawater and sediment from the Florida panhandle coast were assayed for a panel of 28 organochlorine insecticides and PCBs. No samples exeeded the detection limits of the analytical technique, which were well below levels reported for other ocean locales. Organochlorine levels in this area of the Gulf must be very low. This does not preclude their biomagnificatioon up the food web.


Drought Tolerant Plant Species In Jordanian Rangeland, Raed Al-Tabini Oct 2006

Drought Tolerant Plant Species In Jordanian Rangeland, Raed Al-Tabini

Raed Al-Tabini

No abstract provided.


Nnk Activates Erk1/2 And Creb/Atf-1 Via Beta-1-Ar And Egfr Signaling In Human Lung Adenocarcinoma And Small Airway Epithelial Cells, E Laag, M Majidi, Maria Cekanova, T Masi, T Takahashi, Hildegard Schuller Sep 2006

Nnk Activates Erk1/2 And Creb/Atf-1 Via Beta-1-Ar And Egfr Signaling In Human Lung Adenocarcinoma And Small Airway Epithelial Cells, E Laag, M Majidi, Maria Cekanova, T Masi, T Takahashi, Hildegard Schuller

Maria Cekanova MS, RNDr, PhD

We have shown that the tobacco nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) is an agonist for -adrenergic receptors (beta-ARs) and increased DNA synthesis of human lung adenocarcinoma cells with features of bronchiolar Clara cells by binding to these receptors. Using a cell line derived from a human pulmonary adenocarcinoma with Clara cell phenotype (PACC) and immortalized human small airway epithelial cells (HPLD1), the putative cells of origin of this cancer type, our current studies have analyzed signaling initiated by binding of NNK to the beta 1-AR. NNK upregulated ERK1/2 and CREB/ATF-1 phosphorylation in a PKA-dependent manner in ...


Clinical Evaluation Of Dietary Modification For Treatment Of Spontaneous Chronic Kidney Disease In Cats, S Ross, C Osborne, Claudia Kirk, S Lowry, L Koehler, D Polzin Sep 2006

Clinical Evaluation Of Dietary Modification For Treatment Of Spontaneous Chronic Kidney Disease In Cats, S Ross, C Osborne, Claudia Kirk, S Lowry, L Koehler, D Polzin

Claudia A Kirk

Objective-To determine whether a renal diet modified in protein, phosphorus, sodium, and lipid content was superior to an adult maintenance diet in minimizing uremic episodes and mortality rate in cats with stage 2 or 3 chronic kidney disease (CKD). Design-Double-masked, randomized, controlled clinical trial. Animals-45 client-owned cats with spontaneous stage 2 or 3 CKD. Procedures-Cats were randomly assigned to an adult maintenance diet (n = 23 cats) or a renal diet (22) and evaluated trimonthly for up to 24 months. Efficacy of the renal diet, compared with the maintenance diet, in minimizing uremia, renal-related deaths, and all causes of death was ...


Acsm's Metabolic Calculations Handbook, Stephen Glass, Greg Dwyer Aug 2006

Acsm's Metabolic Calculations Handbook, Stephen Glass, Greg Dwyer

Stephen C Glass

This handbook provides a step-by-step approach to using metabolic equations, from basic math principles to applying the equations to an exercise plan. Chapters focus separately on each equation, provide an easy-to-follow process of solving, and demonstrate the varied uses of the equation in clinical as well as fitness settings.

Each chapter includes a set of problems that focus on real-world applications of the equation. Step-by-step problem solution explanations are provided at the end of each chapter. A comprehensive exam at the end of the book tests the reader's skill in using the equations.


Pulmonary Fibroblasts Stimulate The Proliferation Of Cell Lines From Human Lung Adenocarcinomas, Maria Cekanova, T Masi, Howard Plummer, M Majidi, P Fedorocko, Hildegard Schuller Jul 2006

Pulmonary Fibroblasts Stimulate The Proliferation Of Cell Lines From Human Lung Adenocarcinomas, Maria Cekanova, T Masi, Howard Plummer, M Majidi, P Fedorocko, Hildegard Schuller

Maria Cekanova MS, RNDr, PhD

Human lung cancer cell lines are widely used to test anticancer drugs. These in-vitro tests, however, preclude the detection of responses to paracrine factors from surrounding stroma. We have cocultured pulmonary fibroblasts CCD-19Lu, from a healthy donor, or HLF-A, from a patient with epidermoid carcinoma of the lung, with two human pulmonary adenocarcinoma cell lines to test the hypothesis that the fibroblasts stimulate the growth of the tumor cells. Both fibroblast cell lines significantly increased the proliferation of the pulmonary adenocarcinoma cell lines in 3-(4,5-dimethylthiazol-2yl)-2,5-diphenyl tetrazolium bromide assays, with HLF-A fibroblasts yielding the most pronounced responses ...


How Earth Remote Sensing From The International Space Station Complements Current Satellite‐Based Sensors, Jennifer Gebelein, Dean Eppler Jul 2006

How Earth Remote Sensing From The International Space Station Complements Current Satellite‐Based Sensors, Jennifer Gebelein, Dean Eppler

Jennifer Gebelein

The International Space Station (ISS) will provide an Earth‐and space‐observing platform that will support sensors built by 16 different countries and deliver data and images for local, regional and global research. When complete, it will be an exceptional platform for conducting remote sensing of the Earth, astrophysics, and space physics research programmes. Additionally, the ISS will operate as a testbed for engineering studies and complex technological developments that will benefit future Earth‐observing capabilities. ...


Detection Of Overexpressed Cox-2 In Precancerous Lesions Of Hamster Pancreas And Lungs By Molecular Imaging: Implications For Early Diagnosis And Prevention, Hildegard Schuller, George Kabalka, G Smith, A Mereddy, M Akula, Maria Cekanova May 2006

Detection Of Overexpressed Cox-2 In Precancerous Lesions Of Hamster Pancreas And Lungs By Molecular Imaging: Implications For Early Diagnosis And Prevention, Hildegard Schuller, George Kabalka, G Smith, A Mereddy, M Akula, Maria Cekanova

Maria Cekanova MS, RNDr, PhD

The enzyme cyclooxygenase-2 (COX-2) is overexpressed in many cancers, cardiovascular disease, neurodegenerative disorders, and arthritis. Selective inhibitors of COX-2 have been developed as therapeutics or preventive agents for these diseases. However, recent reports have revealed a significant increase in cardiovascular mortality in long-term users of the COX-2 inhibitors Vioxx and Celebrex, emphasizing the need for noninvasive tests that allow the identification of individuals whose COX-2 levels are overexpressed prior to assignment to treatment with these drugs. In this study, we have prepared a radioiodinated analogue of the selective COX-2 inhibitor celecoxib, and verified its binding to the COX-2 enzyme in ...


Reticulocyte Indices In A Canine Model Of Nutritional Iron Deficiency, Michael Fry, Claudia Kirk May 2006

Reticulocyte Indices In A Canine Model Of Nutritional Iron Deficiency, Michael Fry, Claudia Kirk

Claudia A Kirk

BACKGROUND: Reticulocyte indices, especially reticulocyte hemoglobin content (CH retic), have shown promise as markers of iron deficiency (ID), but there have been no prospective investigations of reticulocyte indices in experimental models of ID. OBJECTIVES: The objective of this study was to compare reticulocyte indices with conventional hematologic and biochemical indices as markers of ID in dogs. METHODS: Iron deficiency was induced in 7 dogs by feeding an iron-deficient diet, and corrected by restoring dietary iron and by giving iron parenterally. Blood samples were collected at weekly intervals. Results of hematologic and biochemical tests were compared using t-tests and receiver operator ...


The Inclusion Of Women Cyclists In The Olympics, Shelley Lucas May 2006

The Inclusion Of Women Cyclists In The Olympics, Shelley Lucas

Shelley Lucas

This paper provides preliminary findings from my study of the International Olympic Committee's (IOC) decision to allow women cyclists to compete in the Olympic Games. Male cyclists had contested both road and track cycling events since the resumption of the modern games in 1896, but women were not allowed to compete until 1984—and initially, they were limited to participating in the road race only.


Lysophosphatidic Acid Induces Early Growth Response Gene 1 Expression In Vascular Smooth Muscle Cells: Cre And Sre Mediate The Transcription, Mei-Zhen Cui, E Laag, L Sun, M Tan, G Zhao, Xuemin Xu Apr 2006

Lysophosphatidic Acid Induces Early Growth Response Gene 1 Expression In Vascular Smooth Muscle Cells: Cre And Sre Mediate The Transcription, Mei-Zhen Cui, E Laag, L Sun, M Tan, G Zhao, Xuemin Xu

Xuemin Xu

OBJECTIVE: Lysophosphatidic acid (LPA), one component of oxidized low-density lipoprotein, is a potent bioactive phospholipid. Early growth response gene-1 (Egr-1), an important transcription factor, regulates expression of an array of genes involved in vascular diseases. Whether and how LPA regulates the transcriptional machinery of Egr-1 gene is unknown and is addressed in this study. METHOD AND RESULTS: We found that LPA markedly induces Egr-1 mRNA and protein in aortic smooth muscle cells (SMCs). RNA stability and nuclear run-on assays reveal that LPA-induced Egr-1 gene expression is controlled at the transcriptional level. Reporter gene analyses have shown that the -141 to ...


Scrubby Boys: Scott Young, His Journalism, His Fiction, And His Contributions To The Literature Of Canadian Sport, Don Morrow Apr 2006

Scrubby Boys: Scott Young, His Journalism, His Fiction, And His Contributions To The Literature Of Canadian Sport, Don Morrow

Donald Morrow

No abstract provided.


Comparison Of A Low Carbohydrate-Low Fiber Diet And A Moderate Carbohydrate-High Fiber Diet In The Management Of Feline Diabetes Mellitus, N Bennett, D Greco, M Peterson, Claudia Kirk, M Mathes, M Fettman Mar 2006

Comparison Of A Low Carbohydrate-Low Fiber Diet And A Moderate Carbohydrate-High Fiber Diet In The Management Of Feline Diabetes Mellitus, N Bennett, D Greco, M Peterson, Claudia Kirk, M Mathes, M Fettman

Claudia A Kirk

This study compared the effects of a moderate carbohydrate-high fiber (MC-HF) food and a low carbohydrate-low fiber (LC-LF) food on glycemic control in cats with diabetes mellitus. Sixty-three diabetic cats (48 male castrated, 15 female spayed) were randomly assigned to be fed either a canned MC-HF (n = 32) food or a canned LC-LF (n = 31) food for 16 weeks. Owners were blinded to the type of diet fed. CBC, urinalysis, serum chemistry panel, fructosamine concentration and thyroxine concentration were determined on initial examination, and a complete blood count, serum chemistry panel, urinalysis and serum fructosamine concentration were repeated every 4 ...


Primary Hair Growth In Dogs Depends On Dietary Selenium Concentrations, S Yu, K Wedekind, Claudia Kirk, R Nachreiner Mar 2006

Primary Hair Growth In Dogs Depends On Dietary Selenium Concentrations, S Yu, K Wedekind, Claudia Kirk, R Nachreiner

Claudia A Kirk

Selenium (Se) plays an important role in hair growth. The objective of this study was to investigate the effect of dietary selenium concentration on hair growth in dogs. Thirty-six beagles were stratified into six groups based on age, gender and body condition score. The dogs were fed a torula yeast-based canned food for 3 weeks. Then the dogs were fed varying amounts of selenium supplied as selenomethionine for an additional 24 weeks. Analysed selenium concentrations in the experimental foods for the six groups were 0.04, 0.09, 0.12, 0.54, 1.03 and 5.04 mg/kg dry ...


Against Transcendentalism: The Meaning Of Life And Buddhism, Stephen Asma Mar 2006

Against Transcendentalism: The Meaning Of Life And Buddhism, Stephen Asma

Stephen T Asma

From the 1970s cult TV show, Monty Python’s Flying Circus, to the current hit musical Spamalot, the Monty Python comedy troupe has been at the center of popular culture and entertainment. The Pythons John Cleese, Graham Chapman, Eric Idle, Terry Jones, Michael Palin, and Terry Gilliam are increasingly recognized and honored for their creativity and enduring influence in the worlds of comedy and film. Monty Python and Philosophy extends that recognition into the world of philosophy. Fifteen experts in topics like mythology, Buddhism, feminism, logic, ethics, and the philosophy of science bring their expertise to bear on Python movies ...


Activation Of Protein Kinase C Zeta By Peroxynitrite Regulates Lkb1-Dependent Amp-Activated Protein Kinase In Cultured Endothelial Cells, Z Xie, Y Dong, M Zhang, Mei Cui, R Cohen, U Riek, D Neumann, U Schlattner, M Zou Mar 2006

Activation Of Protein Kinase C Zeta By Peroxynitrite Regulates Lkb1-Dependent Amp-Activated Protein Kinase In Cultured Endothelial Cells, Z Xie, Y Dong, M Zhang, Mei Cui, R Cohen, U Riek, D Neumann, U Schlattner, M Zou

Mei-Zhen Cui

We previously reported the phosphoinositide 3-kinase-dependent activation of the 5'-AMP-activated kinase (AMPK) by peroxynitrite (ONOO-) and hypoxia-reoxygenation in cultured endothelial cells. Here we show the molecular mechanism of activation of this pathway. Exposure of bovine aortic endothelial cells to ONOO- significantly increased the phosphorylation of both Thr172 of AMPK and Ser1179 of endothelial nitric-oxide synthase, a known downstream enzyme of AMPK. In addition, activation of AMPK by ONOO- was accompanied by increased phosphorylation of protein kinase Czeta (PKCzeta) (Thr410/403) and translocation of cytosolic PKCzeta into the membrane. Further, inhibition of PKCzeta abrogated ONOO- -induced AMPK-Thr172 phosphorylation as that ...


The Importance Of Maltose In Transitory Starch Breakdown, Yan Lu, Thomas Sharkey Feb 2006

The Importance Of Maltose In Transitory Starch Breakdown, Yan Lu, Thomas Sharkey

Yan Lu

No abstract provided.


Calpain Inhibitor Mdl28170 Modulates Abeta Formation By Inhibiting The Formation Of Intermediate Abeta46 And Protecting Abeta From Degradation, Y Dong, J Tan, Mei-Zhen Cui, G Zhao, G Mao, N Singh, Xuemin Xu Jan 2006

Calpain Inhibitor Mdl28170 Modulates Abeta Formation By Inhibiting The Formation Of Intermediate Abeta46 And Protecting Abeta From Degradation, Y Dong, J Tan, Mei-Zhen Cui, G Zhao, G Mao, N Singh, Xuemin Xu

Xuemin Xu

The observations that three major cleavages within the transmembrane domain of APP, namely, the gamma-cleavage, -cleavage, and the newly identified zeta-cleavage, are involved in the generation of secreted Abeta40 and Abeta42 prompted us to determine how the calpain inhibitor III MDL 28170 influences these three cleavages and Abeta formation. With the use of a cell culture system, our data demonstrate that 1) at either high concentrations, or at a low range of concentrations, at early time points, MDL 28170 inhibits the formation of secreted Abeta40 and Abeta42. However, this effect is due to inhibition of the intermediate Abeta46 generation by ...


Prevalence And Risk Factors For Obesity In Adult Dogs From Private Us Veterinary Practices, E Lund, P Armstrong, Claudia Kirk, J Klausner Dec 2005

Prevalence And Risk Factors For Obesity In Adult Dogs From Private Us Veterinary Practices, E Lund, P Armstrong, Claudia Kirk, J Klausner

Claudia A Kirk

Using a cross-sectional study design, the prevalence of overweight and obesity in dogs over 1 year of age seen by US veterinarians during 1995 was determined. Risk factors for overweight and obesity were also determined from the following variables: age, breed, gender, body condition score, food type, reported concurrent disease, and geographic region. Thirty-four percent of adult dogs (n=21,754) were overweight or obese. From multivariate analyses, overweight dogs were more likely to be older, of certain breeds (Cocker Spaniel, Labrador Retriever, Dalmatian, Dachshund, Rottweiler, Golden Retriever, Shetland Sheepdog, Mixed-breed), neutered, and to consume a semi-moist food as their ...


The Scent Of Danger: Tetrodotoxin (Ttx) As An Olfactory Cue Of Predation Risk, Richard Zimmer, Daniel Schar, Ryan Ferrer, Patrick Krug, Lee Kats, William Michel Dec 2005

The Scent Of Danger: Tetrodotoxin (Ttx) As An Olfactory Cue Of Predation Risk, Richard Zimmer, Daniel Schar, Ryan Ferrer, Patrick Krug, Lee Kats, William Michel

Lee Kats

Larvae of the California newt (Taricha torosa) exhibit striking predator- avoidance behavior, escaping to refuges in response to a chemical cue from cannibalistic adults. In laboratory flow-tank experiments, stream water collected near free-ranging adults induced hiding responses in 100% of the larvae tested. Solutions prepared by bathing adults (in field and laboratory) also evoked strong hiding behaviors. Insensitive to adult feeding status (fed or starved), and clearly not an excretory product, the chemical cue was released from adult skin (i.e., in swabs of adult backs, sides, and bellies). Tetrodotoxin (TTX) was found in skin swabs of adults and in ...


Synergistic Mitogenic Signaling Of The Tobacco Specific Carcinogen, 4-(Methylnitrosamino)-1-(3-Pyridyl)-1-Butanone (Nnk) And Ethanol On Immortalized Human Pancreatic Duct Epithelial Cells, Mdf Askari, Ms Tsao, Maria Cekanova, Hildegard Schuller Dec 2005

Synergistic Mitogenic Signaling Of The Tobacco Specific Carcinogen, 4-(Methylnitrosamino)-1-(3-Pyridyl)-1-Butanone (Nnk) And Ethanol On Immortalized Human Pancreatic Duct Epithelial Cells, Mdf Askari, Ms Tsao, Maria Cekanova, Hildegard Schuller

Maria Cekanova MS, RNDr, PhD

No abstract provided.


Timelessness And Historicity Of The Game In Ken Dryden's The Game, Don Morrow Dec 2005

Timelessness And Historicity Of The Game In Ken Dryden's The Game, Don Morrow

Donald Morrow

No abstract provided.


Impact Of Co-Active Coaching On Insufficiently Physically Active 12-14 Year Olds In London, Ontario, Canada, Paul Gorczynski, Don Morrow, Jennifer Irwin Dec 2005

Impact Of Co-Active Coaching On Insufficiently Physically Active 12-14 Year Olds In London, Ontario, Canada, Paul Gorczynski, Don Morrow, Jennifer Irwin

Donald Morrow

No abstract provided.


Oestrogen Receptor Evaluation In Pomeranian Dogs With Hair Cycle Arrest (Alopecia X) On Melatonin Supplementation, Linda Frank, Robert Donnell, Stephen Kania Dec 2005

Oestrogen Receptor Evaluation In Pomeranian Dogs With Hair Cycle Arrest (Alopecia X) On Melatonin Supplementation, Linda Frank, Robert Donnell, Stephen Kania

Stephen A Kania

The role of oestrogen receptors in dogs with hair cycle arrest (alopecia X) was investigated by immunohistochemistry. The purpose of this study was to determine if hair regrowth in dogs with hair cycle arrest treated with melatonin was associated with a decrease in follicular oestrogen receptors. Fifteen Pomeranians (excluding intact females) with hair cycle arrest were enrolled. Two biopsies were obtained from alopecic areas of the trunk before and after 3 months on melatonin. Haematoxylin and eosin-stained tissues were examined and oestrogen receptor-alpha was demonstrated immunohistochemically. Common histopathological findings included hyperkeratosis, follicular keratosis, excessive tricholemmal keratinization (flame follicles), thin epidermis ...