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Articles 1 - 14 of 14

Full-Text Articles in Life Sciences

Passive Stiffness In Drosophila Indirect Flight Muscle Reduced By Disrupting Paramyosin Phosphorylation, But Not By Embryonic Myosin S2 Hinge Substitution, Yudong Hao, Mark S. Miller, Douglas M. Swank, Hongjun Liu, Sanford I. Bernstein, David W. Maughan, Gerald H. Pollack Nov 2006

Passive Stiffness In Drosophila Indirect Flight Muscle Reduced By Disrupting Paramyosin Phosphorylation, But Not By Embryonic Myosin S2 Hinge Substitution, Yudong Hao, Mark S. Miller, Douglas M. Swank, Hongjun Liu, Sanford I. Bernstein, David W. Maughan, Gerald H. Pollack

Mark S. Miller

High passive stiffness is one of the characteristic properties of the asynchronous indirect flight muscle (IFM) found in many insects like Drosophila. To evaluate the effects of two thick filament protein domains on passive sarcomeric stiffness, and to investigate their correlation with IFM function, we used microfabricated cantilevers and a high resolution imaging system to study the passive IFM myofibril stiffness of two groups of transgenic Drosophila lines. One group (hinge-switch mutants) had a portion of the endogenous S2 hinge region replaced by an embryonic version; the other group (paramyosin mutants) had one or more putative phosphorylation sites near the ...


Postexercise Insulin Action In African-American Women, Rebecca E. Hasson, Patty S. Freedson, Barry Braun Oct 2006

Postexercise Insulin Action In African-American Women, Rebecca E. Hasson, Patty S. Freedson, Barry Braun

Barry Braun

African Americans are more insulin resistant than Caucasians. A single bout of moderate-intensity exercise reduces insulin resistance in sedentary Caucasian individuals. The impact of a single bout of exercise on insulin resistance has never been studied in African Americans. The purpose of this experiment was to evaluate the impact of a single bout of exercise on insulin resistance in African-American women. DESIGN: Insulin resistance was assessed in 10 sedentary, over-weight or obese African-American women during a sedentary and exercise condition over a two-day period. During the sedentary condition, participants fasted overnight and sat quietly in the laboratory for 75 minutes ...


Cardiac Myosin Missense Mutations Cause Dilated Cardiomyopathy In Mouse Models And Depress Molecular Motor Function, Joachim Schmitt, Edward Debold, Ferhaan Ahmad, Amy Armstrong, Andrea Frederico, David Conner, Ulrike Mende, Martin Lohse, David Warshaw, Christine Seidman, J. Seidman Sep 2006

Cardiac Myosin Missense Mutations Cause Dilated Cardiomyopathy In Mouse Models And Depress Molecular Motor Function, Joachim Schmitt, Edward Debold, Ferhaan Ahmad, Amy Armstrong, Andrea Frederico, David Conner, Ulrike Mende, Martin Lohse, David Warshaw, Christine Seidman, J. Seidman

Edward P. Debold

Dilated cardiomyopathy (DCM) leads to heart failure, a leading cause of death in industrialized nations. Approximately 30% of DCM cases are genetic in origin, with some resulting from point mutations in cardiac myosin, the molecular motor of the heart. The effects of these mutations on myosin's molecular mechanics have not been determined. We have engineered two murine models characterizing the physiological, cellular, and molecular effects of DCM-causing missense mutations (S532P and F764L) in the α-cardiac myosin heavy chain and compared them with WT mice. Mutant mice developed morphological and functional characteristics of DCM consistent with the human phenotypes. Contractile ...


Acsm's Metabolic Calculations Handbook, Stephen Glass, Greg Dwyer Aug 2006

Acsm's Metabolic Calculations Handbook, Stephen Glass, Greg Dwyer

Stephen C Glass

This handbook provides a step-by-step approach to using metabolic equations, from basic math principles to applying the equations to an exercise plan. Chapters focus separately on each equation, provide an easy-to-follow process of solving, and demonstrate the varied uses of the equation in clinical as well as fitness settings.

Each chapter includes a set of problems that focus on real-world applications of the equation. Step-by-step problem solution explanations are provided at the end of each chapter. A comprehensive exam at the end of the book tests the reader's skill in using the equations.


The Inclusion Of Women Cyclists In The Olympics, Shelley Lucas May 2006

The Inclusion Of Women Cyclists In The Olympics, Shelley Lucas

Shelley Lucas

This paper provides preliminary findings from my study of the International Olympic Committee's (IOC) decision to allow women cyclists to compete in the Olympic Games. Male cyclists had contested both road and track cycling events since the resumption of the modern games in 1896, but women were not allowed to compete until 1984—and initially, they were limited to participating in the road race only.


Scrubby Boys: Scott Young, His Journalism, His Fiction, And His Contributions To The Literature Of Canadian Sport, Don Morrow Apr 2006

Scrubby Boys: Scott Young, His Journalism, His Fiction, And His Contributions To The Literature Of Canadian Sport, Don Morrow

Donald Morrow

No abstract provided.


Examining The Direction Of Imagery And Self-Talk On Dart-Throwing Performance And Self Efficacy, Jennifer Cumming, Sanna M. Nordin, Robin Horton, Scott Reynolds Jan 2006

Examining The Direction Of Imagery And Self-Talk On Dart-Throwing Performance And Self Efficacy, Jennifer Cumming, Sanna M. Nordin, Robin Horton, Scott Reynolds

Jennifer Cumming

The study investigated the impact of varying combinations of facilitative and debilitative imagery and self-talk (ST) on self-effi cacy and performance of a dart-throwing task. Participants (N = 95) were allocated to 1 of 5 groups: (a) facilitative imagery/facilitative ST, (b) facilitative imagery/debilitative ST, (c) debilitative imagery/facilitative ST, (d) debilitative imagery/debilitative ST, or (e) control. Mixed-design ANOVAs revealed that performance, but not self-effi - cacy, changed over time as a function of the assigned experimental condition. Participants in the debilitative imagery/debilitative ST condition worsened their performance, and participants in the facilitative imagery/facilitative ST condition achieved better ...


Timelessness And Historicity Of The Game In Ken Dryden's The Game, Don Morrow Dec 2005

Timelessness And Historicity Of The Game In Ken Dryden's The Game, Don Morrow

Donald Morrow

No abstract provided.


Impact Of Co-Active Coaching On Insufficiently Physically Active 12-14 Year Olds In London, Ontario, Canada, Paul Gorczynski, Don Morrow, Jennifer Irwin Dec 2005

Impact Of Co-Active Coaching On Insufficiently Physically Active 12-14 Year Olds In London, Ontario, Canada, Paul Gorczynski, Don Morrow, Jennifer Irwin

Donald Morrow

No abstract provided.


Pka-Mediated Erk1/2 Inactivation And Hsp70 Gene Expression Following Exercise, C.W. Melling, Matthew Krause, Earl Noble Dec 2005

Pka-Mediated Erk1/2 Inactivation And Hsp70 Gene Expression Following Exercise, C.W. Melling, Matthew Krause, Earl Noble

Jamie Melling

Exercise induces the expression of the cardioprotective protein, Hsp70, through the activation of its transcription factor HSF1. Recently, we reported that administration of a protein kinase A (PKA) inhibitor suppressed exercise-induced hsp70 gene expression, suggesting a role for PKA in the regulation of HSF1 activation in vivo. While the mechanism by which PKA regulates HSF1 is unclear, studies in vitro have reported that HSF1 is phosphorylated on two serine residues by mitogen activated protein kinases (MAPKs); ERK1/2 (ser307) and JNK/SAPK (ser363). As PKA is a regulator of these protein kinases, the current study examined the role of PKA ...


Developing Cinquains In Physical Education - A Content Literacy Strategy, Jane Shimon Dec 2005

Developing Cinquains In Physical Education - A Content Literacy Strategy, Jane Shimon

Jane Shimon

No abstract provided.


Imaging Islets Labeled Wth Magnetic Nanoparticules At 1.5 Tesla, J.H. Tai, Paula Foster, Alma Rosales, Biao Feng, Craig Ha, Violetta Martinez, Soha Ramadan, Jonatan Snir, C.W. Melling, Savita Dhanvantari, Brian Rutt, David White Dec 2005

Imaging Islets Labeled Wth Magnetic Nanoparticules At 1.5 Tesla, J.H. Tai, Paula Foster, Alma Rosales, Biao Feng, Craig Ha, Violetta Martinez, Soha Ramadan, Jonatan Snir, C.W. Melling, Savita Dhanvantari, Brian Rutt, David White

Jamie Melling

We have developed a magnetic resonance imaging (MRI) technique for imaging Feridex (superparamagnetic iron oxide [SPIO])-labeled islets of Langerhans using a standard clinical 1.5-Tesla (T) scanner and employing steady-state acquisition imaging sequence (3DFIESTA). Both porcine and rat islets were labeled with SPIO by a transfection technique using a combination of poly-l-lysine and electroporation. Electron microscopy demonstrated presence of SPIO particles within the individual islet cells, including beta-cells and particles trapped between cell membranes. Our labeling method produced a transfection rate of 860 pg to 3.4 ng iron per islet, dependent on the size of the islet. The ...


Obesity Treatment Through Life Coaching, Paul Gorczynski, Don Morrow, Jennifer Irwin Dec 2005

Obesity Treatment Through Life Coaching, Paul Gorczynski, Don Morrow, Jennifer Irwin

Donald Morrow

No abstract provided.


Relations Of Physical Self-Concept And Self-Efficacy With Frequency Of Voluntary Physical Activity In Preadolescents: Implications For After-School Care Programming, Jim Annesi Dec 2005

Relations Of Physical Self-Concept And Self-Efficacy With Frequency Of Voluntary Physical Activity In Preadolescents: Implications For After-School Care Programming, Jim Annesi

Jim Annesi

Objective
This study aimed to test relations of physical self-concept and self-efficacy with voluntaryphysical activity in preadolescents enrolled in an after-school physical activity program.

Methods
Participants in the 2003 (n=41) and 2005 (n=84) versions of the Youth Fit For Life protocol and the control group (n=40) completed the Physical Self-Concept scale, the Exercise Barriers Self-Efficacy Scale for Children, and a recall of physical activity frequency at Weeks 1 and 12.

Results
Both treatment groups demonstrated significantly increased frequency of voluntary physical activity over 12 weeks. The 2005 version additionally demonstrated significant improvements in both physical self-concept ...