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Full-Text Articles in Life Sciences

Enhanced Antiscrapie Effect Using Combination Drug Treatment, D. A. Kocisko, B. Caughey, John D. Morrey, R. E. Race Jan 2006

Enhanced Antiscrapie Effect Using Combination Drug Treatment, D. A. Kocisko, B. Caughey, John D. Morrey, R. E. Race

John D. Morrey

Combination treatment with pentosan polysulfate and Fe(III)meso-tetra(4-sulfonatophenyl)porphine in mice beginning 14 or 28 days after scrapie inoculation significantly increased survival times. This increase may be synergistic, implying that the compounds act cooperatively in vivo. Combination therapy may therefore be more effective for treatment of transmissible spongiform encephalopathies and other protein-misfolding diseases.


A Porphyrin Increases Survival Time Of Mice After Intracerebral Prion Infection, D. A. Kocisko, W. S. Caughey, R. E. Race, G. Roper, B. Caughey, John D. Morrey Jan 2006

A Porphyrin Increases Survival Time Of Mice After Intracerebral Prion Infection, D. A. Kocisko, W. S. Caughey, R. E. Race, G. Roper, B. Caughey, John D. Morrey

John D. Morrey

Prion diseases, including scrapie, are incurable neurodegenerative disorders. Some compounds can delay disease after a peripheral scrapie inoculation, but few are effective against advanced disease. Here, we tested multiple related porphyrins, but only Fe(III)meso-tetra(4-sulfonatophenyl)porphine injected into mouse brains after intracerebral scrapie inoculation substantially increased survival times.