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2006

Genetics and Genomics

Animal science

Articles 1 - 6 of 6

Full-Text Articles in Life Sciences

Use Of Linkage Disequilibrium For Quantitative Trait Loci Mapping In Livestock , Honghua Zhao Jan 2006

Use Of Linkage Disequilibrium For Quantitative Trait Loci Mapping In Livestock , Honghua Zhao

Retrospective Theses and Dissertations

The goal of quantitative trait loci (QTL) mapping in livestock is to find genes underlying traits of economic importance for genetic improvement through marker assisted selection (MAS). The studies presented in this thesis address several important issues in QTL detection and fine mapping using candidate gene analysis and linkage disequilibrium (LD) mapping using high density genotyping. Tests for candidate genes in F2 populations for QTL mapping were developed and evaluated. Results show that the extensive between-breed LD that is present in a cross can result in significant associations for candidate genes at considerable distances from the QTL. Tests that removed ...


Comparison Of Calf-Fed Vs. Yearling-Fed Management For The Estimation Of Carcass Trait Genetic Parameters In Simmental Cattle, Richard G. Tait Jr. Jan 2006

Comparison Of Calf-Fed Vs. Yearling-Fed Management For The Estimation Of Carcass Trait Genetic Parameters In Simmental Cattle, Richard G. Tait Jr.

Retrospective Theses and Dissertations

Selection indexes for feedlot performance have been developed by U.S. beef breed associations to help commercial producers with multiple trait selection decisions. The objective of this study was to evaluate the implications of backgrounding cattle after weaning on selection for feedlot profitability. Carcass data records for 11,011 animals and a three generation pedigree were obtained from the American Simmental Association database. Carcass traits of primary interest in this analysis were marbling score (MARB), 12th rib fat thickness (CFT), 12th rib ribeye area (CREA), and hot carcass weight (HCW). Estimated post weaning gain (EPWG) was determined using ...


Characterization And Interactions Of Tbx2 , Christian Nephi Paxton Jan 2006

Characterization And Interactions Of Tbx2 , Christian Nephi Paxton

Retrospective Theses and Dissertations

T-box (Tbx) proteins are dynamically expressed throughout embryogenesis and appear to have significant roles in a number of developmental processes. The T-box family is characterized by a highly conserved DNA binding domain. Over twenty mammalian T-box proteins have been identified, many of which have the demonstrated ability to regulate transcription. Both activators and repressors of gene transcription have been described within this family, but how their functions are performed is largely unknown;Tbx2 is a powerful transcriptional repressor with functional roles identified in cardiogenesis and limb development. However the functional domain(s) of Tbx2 are poorly characterized. Tbx2 contains a ...


Molecular Dissection Of Genomic Regions Influencing Important Economic Traits In The Pig , Antonio Marcos Costa Do Amaral Ramos Jan 2006

Molecular Dissection Of Genomic Regions Influencing Important Economic Traits In The Pig , Antonio Marcos Costa Do Amaral Ramos

Retrospective Theses and Dissertations

Recently, numerous genes and genomic regions associated with pork quality were identified. There is great potential for the pig industry in using information from molecular markers for the improvement of pork quality traits, such as color, marbling and pH. Besides the traditional fresh pork market, the production of dry-cured pork products, like Country Hams, has also increased. We collected data on fresh and dry-cured Country Hams to investigate the relationships between these traits and to analyze the effect of genetic markers on fresh and dry-cured ham processing characteristics. Significant positive correlations between yield and firmness, color, pH and marbling were ...


Analysis Of Genomic Region(S) And Gene(S) Associated With Cranial Cruciate Ligament Rupture In The Dog , Vicki Lea Wilke Jan 2006

Analysis Of Genomic Region(S) And Gene(S) Associated With Cranial Cruciate Ligament Rupture In The Dog , Vicki Lea Wilke

Retrospective Theses and Dissertations

Rupture of the cranial cruciate ligament (CCLR) in the dog is the most common cause of hind limb lameness. When CCLR occurs it results in instability in the knee leading to progressive, debilitating arthritis and lameness. Particular breeds of dogs (e.g. Newfoundland) are predisposed to CCLR while other breeds (e.g. Greyhound) have dramatically reduced frequency of this disorder supporting a heritable basis for the CCLR trait. For this study, we first estimated the economic impact to veterinary clients for the medical and surgical management for CCLR at 1.3 billion in the U.S. in 2003. Next, we ...


Use Of Qtl Identified In Breed Crosses For Genetic Improvement In Pigs, Napapan Piyasatian Jan 2006

Use Of Qtl Identified In Breed Crosses For Genetic Improvement In Pigs, Napapan Piyasatian

Retrospective Theses and Dissertations

Strategies for the exploitation of multiple QTL identified in breed crosses for genetic improvement of livestock were examined through marker-assisted introgression (MAI) and marker-assisted selection (MAS). Evaluation of the effectiveness of alternate strategies for MAI and MAS were carried out using stochastic computer simulation. In general, introgression of multiple QTL and maintaining the frequency of the donor's allele at 50% requires large population sizes that are not feasible in livestock. An alternate selection approach for MAI of multiple QTL was developed for a breeding program of limited size, without requiring the selected candidates to be heterozygous at all loci ...