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Life Sciences Commons

Open Access. Powered by Scholars. Published by Universities.®

2006

Genetics and Genomics

University of Pennsylvania

Articles 1 - 2 of 2

Full-Text Articles in Life Sciences

Biphosphonate-Mediated Gene Vector Delivery From The Metal Surfaces Of Stents, Ilia Fishbein, Ivan S. Alferiev, Origene Nyanguile, Richard Gaster, John M. Vohs, Gordon Sek-Yin Wong, Howard Felderman, I-Wei Chen, Hoon Choi, Robert L. Wilensky, Robert J. Levy Jan 2006

Biphosphonate-Mediated Gene Vector Delivery From The Metal Surfaces Of Stents, Ilia Fishbein, Ivan S. Alferiev, Origene Nyanguile, Richard Gaster, John M. Vohs, Gordon Sek-Yin Wong, Howard Felderman, I-Wei Chen, Hoon Choi, Robert L. Wilensky, Robert J. Levy

Departmental Papers (CBE)

The clinical use of metallic expandable intravascular stents has resulted in imporved therapeutic outcomes for coronary artery disease. However, arterial reobstruction after stenting, in-stent restenosis, remains an important problem. Gene therapy to treat in-stent restenosis by using gene vector delivery from the metallic stent surfaces has never been demonstrated. The present studies investigated the hypothesis that metal-biphosphonate binding can enable site-specific gene vector delivery from metal surfaces. Polyallylamine biphosphonate (PAA-BP) was synthesized by using Michael addition methodology. Exposure to aqueous solutions of PAA-BP resulted in the formation of a monomolecular biphosphonate later on metal alloy surfaces (steel, nitinol, and cobalt-chromium ...


Spatial Regulation And The Rate Of Signal Transduction Activation, Nizar N. Batada, Larry A. Shepp, David O. Siegmund, Michael Levitt Jan 2006

Spatial Regulation And The Rate Of Signal Transduction Activation, Nizar N. Batada, Larry A. Shepp, David O. Siegmund, Michael Levitt

Statistics Papers

Of the many important signaling events that take place on the surface of a mammalian cell, activation of signal transduction pathways via interactions of cell surface receptors is one of the most important. Evidence suggests that cell surface proteins are not as freely diffusible as implied by the classic fluid mosaic model and that their confinement to membrane domains is regulated. It is unknown whether these dynamic localization mechanisms function to enhance signal transduction activation rate or to minimize cross talk among pathways that share common intermediates. To determine which of these two possibilities is more likely, we derive an ...