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Life Sciences Commons

Open Access. Powered by Scholars. Published by Universities.®

2004

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University of Massachusetts Medical School

Adaptor Proteins, Signal Transducing; Animals; Antigens, Differentiation; Cells, Cultured; DNA-Binding Proteins; Escherichia coli K12; Gene Expression Profiling; Gene Expression Regulation; Genetic Markers; Humans; Inflammation; Interferon Regulatory Factor-3; Kidney; Lipopolysaccharides; Macrophage Activation; Macrophages; Mice; Mice, Inbred C57BL; Microarray Analysis; Myeloid Differentiation Factor 88; NF-kappa B; Proteins; Receptors, Immunologic; Signal Transduction; Toll-Like Receptor 4; Transcription Factors; Transfection

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Full-Text Articles in Life Sciences

The Induction Of Macrophage Gene Expression By Lps Predominantly Utilizes Myd88-Independent Signaling Cascades, Harry Bjorkbacka, Katherine A. Fitzgerald, Francois Huet, Xiaoman Li, James A. Gregory, Melinda Lee, Christine M. Ordija, Nicole E. Dowley, Douglas T. Golenbock, Mason W. Freeman Sep 2004

The Induction Of Macrophage Gene Expression By Lps Predominantly Utilizes Myd88-Independent Signaling Cascades, Harry Bjorkbacka, Katherine A. Fitzgerald, Francois Huet, Xiaoman Li, James A. Gregory, Melinda Lee, Christine M. Ordija, Nicole E. Dowley, Douglas T. Golenbock, Mason W. Freeman

Infectious Diseases and Immunology Publications and Presentations

Myeloid differentiation protein-88 (MyD88) is a signal adaptor protein required for cytokine production following engagement of Toll-like receptors (TLRs) by their cognate ligands. Activation of both TLR-3 and TLR-4, however, can engage signaling events independent of MyD88 expression. The relative importance of these MyD88-dependent and -independent signaling pathways in the macrophage response to lipopolysaccharide (LPS) is unknown. Here we define these events using microarray expression profiling of LPS-stimulated macrophages taken from MyD88-null and wild-type mice. Of the 1,055 genes found to be LPS responsive, only 21.5% were dependent on MyD88 expression, with MyD88-independent genes constituting 74.7% of ...