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Life Sciences Commons

Open Access. Powered by Scholars. Published by Universities.®

2004

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University of Massachusetts Medical School

Action Potentials; Animals; Calcium; Cell Compartmentation; Cell Line; Cells, Cultured; Dendrites; Electric Conductivity; Ethanol; Humans; Ion Channel Gating; Kinetics; Large-Conductance Calcium-Activated Potassium Channels; Male; Neurons; Nucleus Accumbens; Patch-Clamp Techniques; Potassium Channels, Calcium-Activated; Protein Subunits; RNA, Messenger; Rats; Rats, Sprague-Dawley

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Full-Text Articles in Life Sciences

Somatic Localization Of A Specific Large-Conductance Calcium-Activated Potassium Channel Subtype Controls Compartmentalized Ethanol Sensitivity In The Nucleus Accumbens, Gilles E. Martin, Sylvie I. Puig, Andrzej Z. Pietrzykowski, Paula L. Feinberg-Zadek, Patrick Emery, Steven N. Treistman Jul 2004

Somatic Localization Of A Specific Large-Conductance Calcium-Activated Potassium Channel Subtype Controls Compartmentalized Ethanol Sensitivity In The Nucleus Accumbens, Gilles E. Martin, Sylvie I. Puig, Andrzej Z. Pietrzykowski, Paula L. Feinberg-Zadek, Patrick Emery, Steven N. Treistman

Open Access Articles

Alcohol is an addictive drug that targets a variety of ion channels and receptors. To address whether the effects of alcohol are compartment specific (soma vs dendrite), we examined the effects of ethanol (EtOH) on large-conductance calcium-activated potassium channels (BK) in cell bodies and dendrites of freshly isolated neurons from the rat nucleus accumbens (NAcc), a region known to be critical for the development of addiction. Compartment-specific drug action was indeed observed. Clinically relevant concentrations of EtOH increased somatic but not dendritic BK channel open probability. Electrophysiological single-channel recordings and pharmacological analysis of the BK channel in excised patches from ...