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Full-Text Articles in Life Sciences

Newborn Screening For Cystic Fibrosis: Evaluation Of Benefits And Risks And Recommendations For State Newborn Screening Programs, Scott D. Grosse, Coleen A. Boyle, Jeffrey R. Botkin, Anne Marie Comeau, Martin Kharrazi, Margaret Rosenfeld, Benjamin S. Wilfond Oct 2004

Newborn Screening For Cystic Fibrosis: Evaluation Of Benefits And Risks And Recommendations For State Newborn Screening Programs, Scott D. Grosse, Coleen A. Boyle, Jeffrey R. Botkin, Anne Marie Comeau, Martin Kharrazi, Margaret Rosenfeld, Benjamin S. Wilfond

Genetics

In November 2003, CDC and the Cystic Fibrosis Foundation cosponsored a workshop to review the benefits and risks associated with newborn screening for cystic fibrosis (CF). This report describes new research findings and outlines the recommendations of the workshop. The peer-reviewed evidence presented at the workshop supports the clinical utility of newborn screening for CF. Demonstrated long-term benefits from early nutritional treatment as a result of newborn screening for CF include improved growth and, in one study, cognitive development. Other benefits might include reduced hospitalizations and improved survival. Mixed evidence has been reported for pulmonary outcomes. Newborn screening in the ...


Judging A Virus By Its Cover, Eva Szomolanyi-Tsuda, Raymond M. Welsh Oct 2004

Judging A Virus By Its Cover, Eva Szomolanyi-Tsuda, Raymond M. Welsh

Open Access Articles

The production of protective neutralizing antibodies occurs quickly in some viral infections but very slowly in others. In a new study, surface glycoproteins (the targets of neutralization) of 2 different viruses were genetically switched. Analysis of the neutralizing antibody response to each of the 2 parent and recombinant viruses in infected mice revealed that the speed of neutralizing antibody induction was intrinsically dependent on the surface glycoprotein and not the rest of the virus.


Deletion Of The Nucleotide Excision Repair Gene Ercc1 Reduces Immunoglobulin Class Switching And Alters Mutations Near Switch Recombination Junctions, Carol E. Schrader, Joycelyn Vardo, Erin K. Linehan, Michael Z. Twarog, Laura J. Niedernhofer, Jan H. J. Hoeijmakers, Janet Stavnezer Aug 2004

Deletion Of The Nucleotide Excision Repair Gene Ercc1 Reduces Immunoglobulin Class Switching And Alters Mutations Near Switch Recombination Junctions, Carol E. Schrader, Joycelyn Vardo, Erin K. Linehan, Michael Z. Twarog, Laura J. Niedernhofer, Jan H. J. Hoeijmakers, Janet Stavnezer

Women’s Health Research Faculty Publications

The structure-specific endonuclease ERCC1-XPF is an essential component of the nucleotide excision DNA repair pathway. ERCC1-XPF nicks double-stranded DNA immediately adjacent to 3' single-strand regions. Substrates include DNA bubbles and flaps. Furthermore, ERCC1 interacts with Msh2, a mismatch repair (MMR) protein involved in class switch recombination (CSR). Therefore, ERCC1-XPF has abilities that might be useful for antibody CSR. We tested whether ERCC1 is involved in CSR and found that Ercc1(-)(/)(-) splenic B cells show moderately reduced CSR in vitro, demonstrating that ERCC1-XPF participates in, but is not required for, CSR. To investigate the role of ERCC1 in CSR, the nucleotide ...


Prevalence And Antimicrobial Susceptibilities Of Bacteria Isolated From Blood Cultures Of Hospitalized Patients In The United States In 2002, James A. Karlowsky, Mark E. Jones, Deborah C. Draghi, Clyde Thornsberry, Daniel F. Sahm, Gregory A. Volturo May 2004

Prevalence And Antimicrobial Susceptibilities Of Bacteria Isolated From Blood Cultures Of Hospitalized Patients In The United States In 2002, James A. Karlowsky, Mark E. Jones, Deborah C. Draghi, Clyde Thornsberry, Daniel F. Sahm, Gregory A. Volturo

Open Access Articles

BACKGROUND: Bloodstream infections are associated with significant patient morbidity and mortality. Antimicrobial susceptibility patterns should guide the choice of empiric antimicrobial regimens for patients with bacteremia.

METHODS: From January to December of 2002, 82,569 bacterial blood culture isolates were reported to The Surveillance Network (TSN) Database-USA by 268 laboratories. Susceptibility to relevant antibiotic compounds was analyzed using National Committee for Clinical Laboratory Standards guidelines.

RESULTS: Coagulase-negative staphylococci (42.0%), Staphylococcus aureus (16.5%), Enterococcus faecalis (8.3%), Escherichia coli (7.2%), Klebsiella pneumoniae (3.6%), and Enterococcus faecium (3.5%) were the most frequently isolated bacteria from blood cultures ...


Mechanisms Of Tal1 Induced Leukemia In Mice: A Dissertation, Jennifer Elinor O'Neil Jan 2004

Mechanisms Of Tal1 Induced Leukemia In Mice: A Dissertation, Jennifer Elinor O'Neil

GSBS Dissertations and Theses

Activation of the basic helix-loop-helix (bHLH) gene TAL1 is the most common genetic event seen in both childhood and adult T cell acute lymphoblastic leukemia (T-ALL). Despite recent success in treating T-ALL patients, TAL1 patients do not respond well to current therapies. In hopes of leading the way to better therapies for these patients, we have sought to determine the mechanism(s) of Tal1 induced leukemia in mice. By generating a DNA-binding mutant Tal1 transgenic mouse we have determined that the DNA binding activity of Tal1 is not required to induce leukemia. We have also shown that Tal1 expression in ...


Phagocytosis, Innate Immunity, And Host-Pathogen Specificity, Phillip Henneke, Douglas T. Golenbock Jan 2004

Phagocytosis, Innate Immunity, And Host-Pathogen Specificity, Phillip Henneke, Douglas T. Golenbock

Open Access Articles

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