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Full-Text Articles in Life Sciences

Intact Gram-Negative Helicobacter Pylori, Helicobacter Felis, And Helicobacter Hepaticus Bacteria Activate Innate Immunity Via Toll-Like Receptor 2 But Not Toll-Like Receptor 4, Leisa Mandell, Anthony P. Moran, Andrew Cocchiarella, Jeanmarie Houghton, Nancy Taylor, James G. Fox, Timothy C. Wang, Evelyn A. Kurt-Jones Nov 2004

Intact Gram-Negative Helicobacter Pylori, Helicobacter Felis, And Helicobacter Hepaticus Bacteria Activate Innate Immunity Via Toll-Like Receptor 2 But Not Toll-Like Receptor 4, Leisa Mandell, Anthony P. Moran, Andrew Cocchiarella, Jeanmarie Houghton, Nancy Taylor, James G. Fox, Timothy C. Wang, Evelyn A. Kurt-Jones

Open Access Articles

Molecular and genetic studies have demonstrated that members of the Toll-like receptor (TLR) family are critical innate immune receptors. TLRs are recognition receptors for a diverse group of microbial ligands including bacteria, fungi, and viruses. This study demonstrates that distinct TLRs are responsible for the recognition of Helicobacter lipopolysaccharide (LPS) versus intact Helicobacter bacteria. We show that the cytokine-inducing activity of Helicobacter LPS was mediated by TLR4; i.e., TLR4-deficient macrophages were unresponsive to Helicobacter pylori LPS. Surprisingly, the cytokine response to whole Helicobacter bacteria (H. pylori, H. hepaticus, and H. felis) was mediated not by TLR4 but rather by ...


Glycine-Extended Gastrin Promotes The Growth Of Lung Cancer, Theodore J. Koh, John K. Field, Andrea Varro, Triantafillos Liloglou, Pat Fielding, Guanglin Cui, Jeanmarie Houghton, Graham J. Dockray, Timothy C. Wang Jan 2004

Glycine-Extended Gastrin Promotes The Growth Of Lung Cancer, Theodore J. Koh, John K. Field, Andrea Varro, Triantafillos Liloglou, Pat Fielding, Guanglin Cui, Jeanmarie Houghton, Graham J. Dockray, Timothy C. Wang

Open Access Articles

The less processed forms of gastrin have recently been shown to act as trophic factors for both normal and malignant colonic cells. Although incompletely processed forms of gastrin such as glycine-extended gastrin and progastrin are also expressed in human lung cancers, the clinical significance of this expression has not been addressed. Consequently, we investigated the effects of overexpression of glycine-extended gastrin in a mouse strain that is prone to developing lung cancer and also examined the expression of incompletely processed gastrins in primary human lung cancers. We found that transgenic overexpression of glycine-extended gastrin in FVB/N mice resulted in ...