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Mitochondrial Remodeling In Adipose Tissue Associated With Obesity And Treatment With Rosiglitazone, Leanne Wilson-Fritch, Sarah M. Nicoloro, My T. Chouinard, Mitchell A. Lazar, Patricia C. Chui, John D. Leszyk, Juerg R. Straubhaar, Michael P. Czech, Silvia Corvera Nov 2004

Mitochondrial Remodeling In Adipose Tissue Associated With Obesity And Treatment With Rosiglitazone, Leanne Wilson-Fritch, Sarah M. Nicoloro, My T. Chouinard, Mitchell A. Lazar, Patricia C. Chui, John D. Leszyk, Juerg R. Straubhaar, Michael P. Czech, Silvia Corvera

Open Access Articles

Adipose tissue plays a central role in the control of energy homeostasis through the storage and turnover of triglycerides and through the secretion of factors that affect satiety and fuel utilization. Agents that enhance insulin sensitivity, such as rosiglitazone, appear to exert their therapeutic effect through adipose tissue, but the precise mechanisms of their actions are unclear. Rosiglitazone changes the morphological features and protein profiles of mitochondria in 3T3-L1 adipocytes. To examine the relevance of these effects in vivo, we studied white adipocytes from ob/ob mice during the development of obesity and after treatment with rosiglitazone. The levels of ...


A Novel Phosphatidylinositol(3,4,5)P3 Pathway In Fission Yeast, Prasenjit Mitra, Yingjie Zhang, Lucia E. Rameh, Mariya P. Ivshina, Dannel Mccollum, John J. Nunnari, Gregory M. Hendricks, Monica L. Kerr, Seth J. Field, Lewis C. Cantley, Alonzo H. Ross Jul 2004

A Novel Phosphatidylinositol(3,4,5)P3 Pathway In Fission Yeast, Prasenjit Mitra, Yingjie Zhang, Lucia E. Rameh, Mariya P. Ivshina, Dannel Mccollum, John J. Nunnari, Gregory M. Hendricks, Monica L. Kerr, Seth J. Field, Lewis C. Cantley, Alonzo H. Ross

Open Access Articles

The mammalian tumor suppressor, phosphatase and tensin homologue deleted on chromosome 10 (PTEN), inhibits cell growth and survival by dephosphorylating phosphatidylinositol-(3,4,5)-trisphosphate (PI[3,4,5]P3). We have found a homologue of PTEN in the fission yeast, Schizosaccharomyces pombe (ptn1). This was an unexpected finding because yeast (S. pombe and Saccharomyces cerevisiae) lack the class I phosphoinositide 3-kinases that generate PI(3,4,5)P3 in higher eukaryotes. Indeed, PI(3,4,5)P3 has not been detected in yeast. Surprisingly, upon deletion of ptn1 in S. pombe, PI(3,4,5)P3 became detectable at ...