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Novel Insights Into Schwann Cell Dynamics In Peripheral Nervous System Myelination: A Dissertation, Cheryl Lynn Gatto Apr 2004

Novel Insights Into Schwann Cell Dynamics In Peripheral Nervous System Myelination: A Dissertation, Cheryl Lynn Gatto

GSBS Dissertations and Theses

This body of work details the exploitation of an incredibly powerful neural culture system, which enables the in vitrostudy of events involved in peripheral nervous system (PNS) development. Using a myelinating dorsal root ganglion (DRG) explant culture system, node of Ranvier formation and maintenance and the associated generation and maturation of myelin segments was examined. In addition, Schwann cell (SC) development, dynamics, and migration were extensively studied.

First, in characterizing these cultures, the discrete axonal localization of specific ankyrin isoforms was revealed. Ankyrins are peripheral membrane proteins that immobilize classes of integral membrane proteins to the spectrin based-membrane skeleton ...


Mechanisms Of Tal1 Induced Leukemia In Mice: A Dissertation, Jennifer Elinor O'Neil Jan 2004

Mechanisms Of Tal1 Induced Leukemia In Mice: A Dissertation, Jennifer Elinor O'Neil

GSBS Dissertations and Theses

Activation of the basic helix-loop-helix (bHLH) gene TAL1 is the most common genetic event seen in both childhood and adult T cell acute lymphoblastic leukemia (T-ALL). Despite recent success in treating T-ALL patients, TAL1 patients do not respond well to current therapies. In hopes of leading the way to better therapies for these patients, we have sought to determine the mechanism(s) of Tal1 induced leukemia in mice. By generating a DNA-binding mutant Tal1 transgenic mouse we have determined that the DNA binding activity of Tal1 is not required to induce leukemia. We have also shown that Tal1 expression in ...