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Life Sciences Commons

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2004

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Biochemistry, Biophysics, and Structural Biology

Boise State University

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Full-Text Articles in Life Sciences

Interaction Between Amino Propeptides Of Type Xi Procollagen 1 Chains, Julia T. Oxford Mar 2004

Interaction Between Amino Propeptides Of Type Xi Procollagen 1 Chains, Julia T. Oxford

Biomolecular Research Center Publications and Presentations

Type XI collagen is a quantitatively minor yet essential constituent of the cartilage extracellular matrix. The amino propeptide of the 1 chain remains attached to the rest of the molecule for a longer period of time after synthesis than the other amino propeptides of type XI collagen and has been localized to the surface of thin collagen fibrils. Yeast two-hybrid system was used to demonstrate that a homodimer of 1(XI) amino propeptide (1(XI)Npp) could form in vivo. Interaction was also confirmed using multi-angle laser light scattering, detecting an absolute weight average molar mass ranging from the size ...