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2004

Medicine and Health Sciences

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Articles 1 - 30 of 232

Full-Text Articles in Life Sciences

Angiotensin Ii–Induced Protein Kinase D Activation Is Regulated By Protein Kinase C{Delta} And Mediated Via The Angiotensin Ii Type 1 Receptor In Vascular Smooth Muscle Cells, Mingqi Tan, Xuemin Xu, Motoi Ohba, Mei-Zhen Cui Jun 2013

Angiotensin Ii–Induced Protein Kinase D Activation Is Regulated By Protein Kinase C{Delta} And Mediated Via The Angiotensin Ii Type 1 Receptor In Vascular Smooth Muscle Cells, Mingqi Tan, Xuemin Xu, Motoi Ohba, Mei-Zhen Cui

Mei-Zhen Cui

Objective— Angiotensin II (Ang II), through its specific signaling cascades, exerts multiple effects on vascular smooth muscle cells (SMCs). It has been shown that Ang II stimulates activation of protein kinase D (PKD), a member of a new class of serine–threonine kinases. However, little is known regarding the upstream cascade of the intracellular signaling that leads to PKD activation. In the present study, we investigated upstream molecules that mediate Ang II–induced PKD activation in SMCs. Methods and Results— Protein kinase C (PKC) inhibitors completely block Ang II–induced PKD activation, and pretreatment with phorbol 12,13-dibutyrate downregulates Ang ...


Identification Of A New Presenilin-Dependent Zeta-Cleavage Site Within The Transmembrane Domain Of Amyloid Precursor Protein, G Zhao, G Mao, J Tan, Y Dong, Mei-Zhen Cui, Sh Kim, Xuemin Xu Jun 2013

Identification Of A New Presenilin-Dependent Zeta-Cleavage Site Within The Transmembrane Domain Of Amyloid Precursor Protein, G Zhao, G Mao, J Tan, Y Dong, Mei-Zhen Cui, Sh Kim, Xuemin Xu

Mei-Zhen Cui

Gamma-secretase cleavage of beta-amyloid precursor protein (APP) is crucial in the pathogenesis of Alzheimer disease, because it is the decisive step in the formation of the C terminus of beta-amyloid protein (Abeta). To better understand the molecular events involved in gamma-secretase cleavage of APP, in this study we report the identification of a new intracellular long Abeta species containing residues 1-46 (Abeta46), which led to the identification of a novel zeta-cleavage site between the known gamma- and epsilon-cleavage sites within the transmembrane domain of APP. Our data clearly demonstrate that the new zeta-cleavage is a presenilin-dependent event. It is also ...


Modulating Hiv-1 Replication By Rna Interference Directed Against Human Transcription Elongation Factor Spt5, Yueh-Hsin Ping, Chia-Ying Chu, Hong Cao, Jean-Marc Jacque, Mario Stevenson, Tariq M. Rana Dec 2004

Modulating Hiv-1 Replication By Rna Interference Directed Against Human Transcription Elongation Factor Spt5, Yueh-Hsin Ping, Chia-Ying Chu, Hong Cao, Jean-Marc Jacque, Mario Stevenson, Tariq M. Rana

Open Access Articles

BACKGROUND: Several cellular positive and negative elongation factors are involved in regulating RNA polymerase II processivity during transcription elongation in human cells. In recruiting several of these regulatory factors to the 5' long terminal repeat (LTR) promoter during transcription elongation, HIV-1 modulates replication of its genome in a process mediated by the virus-encoded transactivator Tat. One particular cellular regulatory factor, DSIF subunit human SPT5 (hSpt5), has been implicated in both positively and negatively regulating transcriptional elongation but its role in Tat transactivation in vivo and in HIV-1 replication has not been completely elucidated. RESULTS: To understand the in vivo function ...


Regulation Of Cell Cycle By The Anaphase Spindle Midzone, Maki Murata-Hori, Greenfield Sluder, Yu-Li Wang Dec 2004

Regulation Of Cell Cycle By The Anaphase Spindle Midzone, Maki Murata-Hori, Greenfield Sluder, Yu-Li Wang

Open Access Articles

BACKGROUND: A number of proteins accumulate in the spindle midzone and midbody of dividing animal cells. Besides proteins essential for cytokinesis, there are also components essential for interphase functions, suggesting that the spindle midzone and/or midbody may play a role in regulating the following cell cycle.

RESULTS: We microsurgically severed NRK epithelial cells during anaphase or telophase, such that the spindle midzone/midbody was associated with only one of the daughter cells. Time-lapse recording of cells severed during early anaphase indicated that the cell with midzone underwent cytokinesis-like cortical contractions and progressed normally through the interphase, whereas the cell ...


Identification Of A New Presenilin-Dependent Zeta-Cleavage Site Within The Transmembrane Domain Of Amyloid Precursor Protein, G Zhao, G Mao, J Tan, Y Dong, Mei-Zhen Cui, Sh Kim, Xuemin Xu Dec 2004

Identification Of A New Presenilin-Dependent Zeta-Cleavage Site Within The Transmembrane Domain Of Amyloid Precursor Protein, G Zhao, G Mao, J Tan, Y Dong, Mei-Zhen Cui, Sh Kim, Xuemin Xu

Xuemin Xu

Gamma-secretase cleavage of beta-amyloid precursor protein (APP) is crucial in the pathogenesis of Alzheimer disease, because it is the decisive step in the formation of the C terminus of beta-amyloid protein (Abeta). To better understand the molecular events involved in gamma-secretase cleavage of APP, in this study we report the identification of a new intracellular long Abeta species containing residues 1-46 (Abeta46), which led to the identification of a novel zeta-cleavage site between the known gamma- and epsilon-cleavage sites within the transmembrane domain of APP. Our data clearly demonstrate that the new zeta-cleavage is a presenilin-dependent event. It is also ...


Novel Role For A Sterol Response Element Binding Protein In Directing Spermatogenic Cell-Specific Gene Expression, Hong Wang, Jovenal T. San Agustin, George B. Witman, Daniel L. Kilpatrick Dec 2004

Novel Role For A Sterol Response Element Binding Protein In Directing Spermatogenic Cell-Specific Gene Expression, Hong Wang, Jovenal T. San Agustin, George B. Witman, Daniel L. Kilpatrick

Open Access Articles

Sperm are highly specialized cells, and their formation requires the synthesis of a large number of unique mRNAs. However, little is known about the transcriptional mechanisms that direct male germ cell differentiation. Sterol response element binding protein 2gc (SREBP2gc) is a spermatogenic cell-enriched isoform of the ubiquitous transcription factor SREBP2, which in somatic cells is required for homeostatic regulation of cholesterol. SREBP2gc is selectively enriched in spermatocytes and spermatids, and, due to its novel structure, its synthesis is not subject to cholesterol feedback control. This suggested that SREBP2gc has unique cell- and stage-specific functions during spermatogenesis. Here, we demonstrate that ...


Respiratory Symptoms In Relation To Residential Coal Burning And Environmental Tobacco Smoke Among Early Adolescents In Wuhan, China: A Cross-Sectional Study, C. Anderson Johnson, Jiang Xia, Päivi M. Salo, Yan Li, Grace E. Kissling, Edward L. Avol, Chunhong Liu, Stephanie J. London Dec 2004

Respiratory Symptoms In Relation To Residential Coal Burning And Environmental Tobacco Smoke Among Early Adolescents In Wuhan, China: A Cross-Sectional Study, C. Anderson Johnson, Jiang Xia, Päivi M. Salo, Yan Li, Grace E. Kissling, Edward L. Avol, Chunhong Liu, Stephanie J. London

CGU Faculty Publications and Research

Background

Cigarette smoking and coal burning are the primary sources of indoor air pollution in Chinese households. However, effects of these exposures on Chinese children's respiratory health are not well characterized.

Methods

Seventh grade students (N = 5051) from 22 randomly selected schools in the greater metropolitan area of Wuhan, China, completed an in-class self-administered questionnaire on their respiratory health and home environment.

Results

Coal burning for cooking and/or heating increased odds of wheezing with colds [odds ratio (OR) = 1.57, 95% confidence interval (CI): 1.07–2.29] and without colds (OR = 1.44, 95% CI: 1.05 ...


What Is Whirling Disease?, Mohamed Faisal, Donald Garling Dec 2004

What Is Whirling Disease?, Mohamed Faisal, Donald Garling

NCRAC Extension Fact Sheets

Whirling disease is the common name for an infection in salmonids caused by the protozoan, Myxobolus cerebralis. Diseased fish usually show signs of circular swimming, hence the disease name “whirling.” In addition, diseased fish may show other signs, such as black tail, skeletal deformities, and shortened gill cover. Because of the erratic, uncontrolled circular swimming, the fish are unable to eat or escape predators. Myxobolus cerebralis has a two-host life cycle, alternating between salmonid fish species and a benthic organism, the worm, Tubifex tubifex. The worms live in the mud of streams. As many as 10,000 worms can be ...


Association Of Dc-Sign Promoter Polymorphism With Increased Risk For Parenteral, But Not Mucosal, Acquisition Of Human Immunodeficiency Virus Type 1 Infection, Maureen P. Martin, Michael M. Lederman, Holli B. Hutcheson, James J. Goedert, George W. Nelson, Yvette Van Kooyk, Roger Detels, Susan Buchbinder, Keith Hoots, David Vlahov, Stephen J. O'Brien, Mary Carrington Dec 2004

Association Of Dc-Sign Promoter Polymorphism With Increased Risk For Parenteral, But Not Mucosal, Acquisition Of Human Immunodeficiency Virus Type 1 Infection, Maureen P. Martin, Michael M. Lederman, Holli B. Hutcheson, James J. Goedert, George W. Nelson, Yvette Van Kooyk, Roger Detels, Susan Buchbinder, Keith Hoots, David Vlahov, Stephen J. O'Brien, Mary Carrington

Biology Faculty Articles

There is considerable debate about the fundamental mechanisms that underlie and restrict acquisition of human immunodeficiency virus type 1 (HIV-1) infection. In light of recent studies demonstrating the ability of C type lectins to facilitate infection with HIV-1, we explored the potential relationship between polymorphisms in the DC-SIGN promoter and risk for acquisition of HIV-1 according to route of infection. Using samples obtained from 1,611 European-American participants at risk for parenteral (n = 713) or mucosal (n = 898) infection, we identified single-nucleotide polymorphisms in the DC-SIGN promoter using single-strand conformation polymorphism. Individuals at risk for parenterally acquired infection who had ...


Arkansas Animal Science Department Report 2004, Zelpha B. Johnson, D. Wayne Kellogg Dec 2004

Arkansas Animal Science Department Report 2004, Zelpha B. Johnson, D. Wayne Kellogg

Research Series

No abstract provided.


Angiotensin Ii–Induced Protein Kinase D Activation Is Regulated By Protein Kinase C{Delta} And Mediated Via The Angiotensin Ii Type 1 Receptor In Vascular Smooth Muscle Cells, Mingqi Tan, Xuemin Xu, Motoi Ohba, Mei-Zhen Cui Nov 2004

Angiotensin Ii–Induced Protein Kinase D Activation Is Regulated By Protein Kinase C{Delta} And Mediated Via The Angiotensin Ii Type 1 Receptor In Vascular Smooth Muscle Cells, Mingqi Tan, Xuemin Xu, Motoi Ohba, Mei-Zhen Cui

Xuemin Xu

Objective— Angiotensin II (Ang II), through its specific signaling cascades, exerts multiple effects on vascular smooth muscle cells (SMCs). It has been shown that Ang II stimulates activation of protein kinase D (PKD), a member of a new class of serine–threonine kinases. However, little is known regarding the upstream cascade of the intracellular signaling that leads to PKD activation. In the present study, we investigated upstream molecules that mediate Ang II–induced PKD activation in SMCs. Methods and Results— Protein kinase C (PKC) inhibitors completely block Ang II–induced PKD activation, and pretreatment with phorbol 12,13-dibutyrate downregulates Ang ...


Lateral Hypothalamic Signaling Mechanisms Underlying Feeding Stimulation: Differential Contributions Of Src Family Tyrosine Kinases To Feeding Triggered Either By Nmda Injection Or By Food Deprivation, Arshad Khan, Herman H. Cheung, Elizabeth R. Gillard, Jennifer A. Palarca, Derek S. Welsbie, James W. Gurd, B. Glenn Stanley Nov 2004

Lateral Hypothalamic Signaling Mechanisms Underlying Feeding Stimulation: Differential Contributions Of Src Family Tyrosine Kinases To Feeding Triggered Either By Nmda Injection Or By Food Deprivation, Arshad Khan, Herman H. Cheung, Elizabeth R. Gillard, Jennifer A. Palarca, Derek S. Welsbie, James W. Gurd, B. Glenn Stanley

Arshad M. Khan, Ph.D.

No abstract provided.


Overexpression Of Glycine-Extended Gastrin Inhibits Parietal Cell Loss And Atrophy In The Mouse Stomach, Guanglin Cui, Theodore J. Koh, Duan Chen, Chun-Mei Zhao, Shigeo Takaishi, Graham J. Dockray, Andrea Varro, Arlin B. Rogers, James G. Fox, Timothy C. Wang Nov 2004

Overexpression Of Glycine-Extended Gastrin Inhibits Parietal Cell Loss And Atrophy In The Mouse Stomach, Guanglin Cui, Theodore J. Koh, Duan Chen, Chun-Mei Zhao, Shigeo Takaishi, Graham J. Dockray, Andrea Varro, Arlin B. Rogers, James G. Fox, Timothy C. Wang

Open Access Articles

Recently we have reported synergistic effects between glycine-extended gastrin (G-gly) and amidated gastrin-17 on acid secretion in short-term infusion studies. In the present study, we examined the long-term effect of G-gly on the atrophy-promoting effects of amidated gastrin in the mouse stomach with or without Helicobacter infection. Transgenic mice overexpressing amidated gastrin (INS-GAS mice), G-gly (MTI/G-gly mice), and both peptides (INS-GAS/G-gly mice) were used for assessment of acid secretion and ulcer susceptibility and histologic examination and scoring of preneoplastic lesions in response to the 3 and 6 months Helicobacter felis (H. felis) infection. We found that MTI/G-gly ...


Evaluating Forensic Dna Evidence: Essential Elements Of A Competent Defense Review, Dan E. Krane Nov 2004

Evaluating Forensic Dna Evidence: Essential Elements Of A Competent Defense Review, Dan E. Krane

Biological Sciences Faculty Publications

No abstract provided.


Bicistronic And Fused Monocistronic Transcripts Are Derived From Adjacent Loci In The Arabidopsis Genome, Jyothi Thimmapuram, Hui Duan, Lei Liu, Mary A. Schuler Nov 2004

Bicistronic And Fused Monocistronic Transcripts Are Derived From Adjacent Loci In The Arabidopsis Genome, Jyothi Thimmapuram, Hui Duan, Lei Liu, Mary A. Schuler

Cyber Center Publications

Comparisons of full-length cDNAs and genomic DNAs available for Arabidopsis thaliana described here indicate that some adjacent loci are transcribed into extremely long RNAs spanning two annotated genes. Once expressed, some of these transcripts are post-transcriptionally spliced within their coding and intergenic sequences to generate bicistronic transcripts containing two complete open reading frames. Others are spliced to generate monocistronic transcripts coding for fusion proteins with sequences derived from both loci. RT-PCR of several P450 transcripts in this collection indicates that these extended transcripts exist side by side with shorter monocistronic transcripts derived from the individual loci in each pair. The ...


Inducible Changes In Cell Size And Attachment Area Due To Expression Of A Mutant Swi/Snf Chromatin Remodeling Enzyme, David A. Hill, Simion I. Chiosea, Saha Jamaluddin, Kanaklata Roy, Andrew H. Fischer, Douglas D. Boyd, Jeffrey A. Nickerson, Anthony N. Imbalzano Nov 2004

Inducible Changes In Cell Size And Attachment Area Due To Expression Of A Mutant Swi/Snf Chromatin Remodeling Enzyme, David A. Hill, Simion I. Chiosea, Saha Jamaluddin, Kanaklata Roy, Andrew H. Fischer, Douglas D. Boyd, Jeffrey A. Nickerson, Anthony N. Imbalzano

Open Access Articles

The SWI/SNF enzymes belong to a family of ATP-dependent chromatin remodeling enzymes that have been functionally implicated in gene regulation, development, differentiation and oncogenesis. BRG1, the catalytic core subunit of some of the SWI/SNF enzymes, can interact with known tumor suppressor proteins and can act as a tumor suppressor itself. We report that cells that inducibly express ATPase-deficient versions of BRG1 increase in cell volume, area of attachment and nuclear size upon expression of the mutant BRG1 protein. Examination of focal adhesions reveals qualitative changes in paxillin distribution but no difference in the actin cytoskeletal structure. Increases in ...


High-Resolution Serum Proteomic Patterns For Ovarian Cancer Detection, Keith A. Baggerly, Sarah R. Edmonson, Jeffrey S. Morris, Kevin R. Coombes Nov 2004

High-Resolution Serum Proteomic Patterns For Ovarian Cancer Detection, Keith A. Baggerly, Sarah R. Edmonson, Jeffrey S. Morris, Kevin R. Coombes

Jeffrey S. Morris

No abstract provided.


Evaluating The Influence Of Massage On Leg Strength, Swelling, And Pain Following A Half-Marathon, Lance G. Dawson, Kimberley A. Dawson, Peter M. Tiidus Nov 2004

Evaluating The Influence Of Massage On Leg Strength, Swelling, And Pain Following A Half-Marathon, Lance G. Dawson, Kimberley A. Dawson, Peter M. Tiidus

Kinesiology and Physical Education Faculty Publications

Massage therapy is commonly used following endurance running races with the expectation that it will enhance post-run recovery of muscle function and reduce soreness. A limited number of studies have reported little or no influence of massage therapy on post-exercise muscle recovery. However, no studies have been conducted in a field setting to assess the potential for massage to influence muscle recovery following an actual endurance running race. To evaluate the potential for repeated massage therapy interventions to influence recovery of quadriceps and hamstring muscle soreness, recovery of quadriceps and hamstring muscle strength and reduction of upper leg muscle swelling ...


Understanding The Role Of Behavior And Cognitions In A Group Exercise Setting, Tina L. Shrigley, Kimberley A. Dawson Nov 2004

Understanding The Role Of Behavior And Cognitions In A Group Exercise Setting, Tina L. Shrigley, Kimberley A. Dawson

Kinesiology and Physical Education Faculty Publications

The first purpose of the present study examined whether individuals with different exercise behaviors (classified by attendance) experienced different or similar cognitive patterns. It was hypothesized that different behavior would lead to different cognitive appraisals. It was predicted that there would be a difference between the three behavioral frequency groups with regard to self-efficacy measures and goal measures. The second purpose of the study was to describe, evaluate and observe whether social factors were associated with participating in exercise in groups. It was hypothesized that those who engage in exercise classes would elicit a social focus. Participants for the study ...


Eradicating Footrot From Western Australia - A Farmer's Guide, Department Of Agriculture, Western Australia Nov 2004

Eradicating Footrot From Western Australia - A Farmer's Guide, Department Of Agriculture, Western Australia

Miscellaneous Publications

Virulent footrot can occur on any farm in the medium to high rainfall zone. Persons who regularly buy and sell sheep take a greater risk, but even properties with a closed breeding flock are at risk from stray sheep. People often associate footrot with properties managed by inefficient farmers. This is a false belief. Many good farmers have found the disease in their sheep, including high profile studs. Footrot can strike anywhere and often without warning. It is important to remember that once it is found; getting to know and understand the disease will help you to beat it. A ...


Intact Gram-Negative Helicobacter Pylori, Helicobacter Felis, And Helicobacter Hepaticus Bacteria Activate Innate Immunity Via Toll-Like Receptor 2 But Not Toll-Like Receptor 4, Leisa Mandell, Anthony P. Moran, Andrew Cocchiarella, Jeanmarie Houghton, Nancy Taylor, James G. Fox, Timothy C. Wang, Evelyn A. Kurt-Jones Nov 2004

Intact Gram-Negative Helicobacter Pylori, Helicobacter Felis, And Helicobacter Hepaticus Bacteria Activate Innate Immunity Via Toll-Like Receptor 2 But Not Toll-Like Receptor 4, Leisa Mandell, Anthony P. Moran, Andrew Cocchiarella, Jeanmarie Houghton, Nancy Taylor, James G. Fox, Timothy C. Wang, Evelyn A. Kurt-Jones

Open Access Articles

Molecular and genetic studies have demonstrated that members of the Toll-like receptor (TLR) family are critical innate immune receptors. TLRs are recognition receptors for a diverse group of microbial ligands including bacteria, fungi, and viruses. This study demonstrates that distinct TLRs are responsible for the recognition of Helicobacter lipopolysaccharide (LPS) versus intact Helicobacter bacteria. We show that the cytokine-inducing activity of Helicobacter LPS was mediated by TLR4; i.e., TLR4-deficient macrophages were unresponsive to Helicobacter pylori LPS. Surprisingly, the cytokine response to whole Helicobacter bacteria (H. pylori, H. hepaticus, and H. felis) was mediated not by TLR4 but rather by ...


Evaluating Forensic Dna Evidence, Dan E. Krane Oct 2004

Evaluating Forensic Dna Evidence, Dan E. Krane

Biological Sciences Faculty Publications

No abstract provided.


Gel Shift Analysis Of The Empa Promoter Region In Vibrio Anguillarum, Steven M. Denkin, Pedja Sekaric, David R. Nelson Oct 2004

Gel Shift Analysis Of The Empa Promoter Region In Vibrio Anguillarum, Steven M. Denkin, Pedja Sekaric, David R. Nelson

Open Access Articles

BACKGROUND: The induction of metalloprotease encoded by empA in Vibrio anguillarum occurs at high cell density in salmon intestinal mucus. Previously we have shown that there are significant differences in empA expression in two strains of V. anguillarum, M93Sm and NB10. It is hypothesized that differences in empA regulation are due to differences in binding of regulatory elements.

RESULTS: Two strains of V. anguillarum, M93Sm and NB10, were examined and compared for the presence of DNA regulatory proteins that bind to and control the empA promoter region. Gel mobility shift assays, using a digoxigenin (DIG)-labeled oligomer containing a lux ...


Front Matter, Vol. 64 No. 4 Oct 2004

Front Matter, Vol. 64 No. 4

Western North American Naturalist

No abstract provided.


End Matter, Vol. 64 No. 4 Oct 2004

End Matter, Vol. 64 No. 4

Western North American Naturalist

No abstract provided.


2004 Scholars And Artists Bibliography, Michael Schwartz Library, Cleveland State University, Friends Of The Michael Schwartz Library Oct 2004

2004 Scholars And Artists Bibliography, Michael Schwartz Library, Cleveland State University, Friends Of The Michael Schwartz Library

Scholars and Artists Bibliographies

This bibliography was created for the annual Friends of the Michael Schwartz Library Scholars and Artists Reception, recognizing scholarly and creative achievements of Cleveland State University faculty, staff and emeriti


Forensic Dna Evidence: Collection, Mixtures, And Degradation, Dan E. Krane Oct 2004

Forensic Dna Evidence: Collection, Mixtures, And Degradation, Dan E. Krane

Biological Sciences Faculty Publications

No abstract provided.


Structural Basis For Coevolution Of A Human Immunodeficiency Virus Type 1 Nucleocapsid-P1 Cleavage Site With A V82a Drug-Resistant Mutation In Viral Protease, Moses Prabu-Jeyabalan, Ellen A. Nalivaika, Nancy M. King, Celia A. Schiffer Oct 2004

Structural Basis For Coevolution Of A Human Immunodeficiency Virus Type 1 Nucleocapsid-P1 Cleavage Site With A V82a Drug-Resistant Mutation In Viral Protease, Moses Prabu-Jeyabalan, Ellen A. Nalivaika, Nancy M. King, Celia A. Schiffer

Open Access Articles

Maturation of human immunodeficiency virus (HIV) depends on the processing of Gag and Pol polyproteins by the viral protease, making this enzyme a prime target for anti-HIV therapy. Among the protease substrates, the nucleocapsid-p1 (NC-p1) sequence is the least homologous, and its cleavage is the rate-determining step in viral maturation. In the other substrates of HIV-1 protease, P1 is usually either a hydrophobic or an aromatic residue, and P2 is usually a branched residue. NC-p1, however, contains Asn at P1 and Ala at P2. In response to the V82A drug-resistant protease mutation, the P2 alanine of NC-p1 mutates to valine ...


The 4q Subtelomere Harboring The Fshd Locus Is Specifically Anchored With Peripheral Heterochromatin Unlike Most Human Telomeres, Rose Tam, Kelly P. Smith, Jeanne B. Lawrence Oct 2004

The 4q Subtelomere Harboring The Fshd Locus Is Specifically Anchored With Peripheral Heterochromatin Unlike Most Human Telomeres, Rose Tam, Kelly P. Smith, Jeanne B. Lawrence

Open Access Articles

This paper investigates the nuclear localization of human telomeres and, specifically, the 4q35 subtelomere mutated in facioscapulohumeral dystrophy (FSHD). FSHD is a common muscular dystrophy that has been linked to contraction of D4Z4 tandem repeats, widely postulated to affect distant gene expression. Most human telomeres, such as 17q and 17p, avoid the nuclear periphery to reside within the internal, euchromatic compartment. In contrast, 4q35 localizes at the peripheral heterochromatin with 4p more internal, generating a reproducible chromosome orientation that we relate to gene expression profiles. Studies of hybrid and translocation cell lines indicate this localization is inherent to the distal ...


Trends In Aids-Defining And Non-Aids-Defining Malignancies Among Hiv-Infected Patients: 1989-2002, Roger Bedimo, Ray Y. Chen, Neil A. Accortt, James L. Raper, Carol Linn, Jeroan J. Allison, John Dubay, Michael S. Saag, Craig J. Hoesley Oct 2004

Trends In Aids-Defining And Non-Aids-Defining Malignancies Among Hiv-Infected Patients: 1989-2002, Roger Bedimo, Ray Y. Chen, Neil A. Accortt, James L. Raper, Carol Linn, Jeroan J. Allison, John Dubay, Michael S. Saag, Craig J. Hoesley

Population and Quantitative Health Sciences Publications

In a comparison of rates of acquired immunodeficiency syndrome (AIDS)-defining malignancies (ADMs) for 1989-1996 versus 1997-2002, we found a decrease in ADMs (rate ratio, 0.31; P<.0001) and a significant increase in non-AIDS-defining malignancies (non-ADMs; rate ratio, 10.87; P<.0002). The mean CD4 cell count was lower among patients with ADMs than among those with non-ADMs. A longer duration of survival during highly active antiretroviral therapy might explain the increasing incidence of non-ADMs.