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Biology Faculty Publications and Presentations

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Full-Text Articles in Life Sciences

Where To Forage When Afraid: Does Perceived Risk Impair Use Of The Foodscape?, Samantha P.H. Dwinnell, Hall Sawyer, Jill E. Randall, Jeffery L. Beck, Jennifer S. Forbey, Gary L. Fralick, Kevin L. Monteith Oct 2019

Where To Forage When Afraid: Does Perceived Risk Impair Use Of The Foodscape?, Samantha P.H. Dwinnell, Hall Sawyer, Jill E. Randall, Jeffery L. Beck, Jennifer S. Forbey, Gary L. Fralick, Kevin L. Monteith

Biology Faculty Publications and Presentations

The availability and quality of forage on the landscape constitute the foodscape within which animals make behavioral decisions to acquire food. Novel changes to the foodscape, such as human disturbance, can alter behavioral decisions that favor avoidance of perceived risk over food acquisition. Although behavioral changes and population declines often coincide with the introduction of human disturbance, the link(s) between behavior and population trajectory are difficult to elucidate. To identify a pathway by which human disturbance may affect ungulate populations, we tested the Behaviorally Mediated Forage‐Loss Hypothesis, wherein behavioral avoidance is predicted to reduce use of available forage ...


Phylogenomics Resolves Major Relationships And Reveals Significant Diversification Rate Shifts In The Evolution Of Silk Moths And Relatives, J. R. Barber Sep 2019

Phylogenomics Resolves Major Relationships And Reveals Significant Diversification Rate Shifts In The Evolution Of Silk Moths And Relatives, J. R. Barber

Biology Faculty Publications and Presentations

Background: Silkmoths and their relatives constitute the ecologically and taxonomically diverse superfamily Bombycoidea, which includes some of the most charismatic species of Lepidoptera. Despite displaying spectacular forms and diverse ecological traits, relatively little attention has been given to understanding their evolution and drivers of their diversity. To begin to address this problem, we created a new Bombycoidea-specific Anchored Hybrid Enrichment (AHE) probe set and sampled up to 571 loci for 117 taxa across all major lineages of the Bombycoidea, with a newly developed DNA extraction protocol that allows Lepidoptera specimens to be readily sequenced from pinned natural history collections.

Results ...


Adaptive Responses Of Animals To Climate Change Are Most Likely Insufficient, Viktoriia Radchuk, Thomas Reed, Céline Teplitsky, Martijn Van De Pol, Anne Charmantier, Christopher Hassall, Peter Adamík, Frank Adriaensen, Markus P. Ahola, Karl S. Berg Jul 2019

Adaptive Responses Of Animals To Climate Change Are Most Likely Insufficient, Viktoriia Radchuk, Thomas Reed, Céline Teplitsky, Martijn Van De Pol, Anne Charmantier, Christopher Hassall, Peter Adamík, Frank Adriaensen, Markus P. Ahola, Karl S. Berg

Biology Faculty Publications and Presentations

Biological responses to climate change have been widely documented across taxa and regions, but it remains unclear whether species are maintaining a good match between phenotype and environment, i.e. whether observed trait changes are adaptive. Here we reviewed 10,090 abstracts and extracted data from 71 studies reported in 58 relevant publications, to assess quantitatively whether phenotypic trait changes associated with climate change are adaptive in animals. A meta-analysis focussing on birds, the taxon best represented in our dataset, suggests that global warming has not systematically affected morphological traits, but has advanced phenological traits. We demonstrate that these advances ...


Complex History Of Codiversification And Host Switching Of A Newfound Soricid-Borne Orthohantavirus In North America, Schuyler W. Liphardt, Hae Ji Kang, Laurie J. Dizney, Luis A. Ruedas, Joseph A. Cook, Richard Yanagihara Jul 2019

Complex History Of Codiversification And Host Switching Of A Newfound Soricid-Borne Orthohantavirus In North America, Schuyler W. Liphardt, Hae Ji Kang, Laurie J. Dizney, Luis A. Ruedas, Joseph A. Cook, Richard Yanagihara

Biology Faculty Publications and Presentations

Orthohantaviruses are tightly linked to the ecology and evolutionary history of their mammalian hosts. We hypothesized that in regions with dramatic climate shifts throughout the Quaternary, orthohantavirus diversity and evolution are shaped by dynamic host responses to environmental change through processes such as host isolation, host switching, and reassortment. Jemez Springs virus (JMSV), an orthohantavirus harbored by the dusky shrew (Sorex monticola) and five close relatives distributed widely in western North America, was used to test this hypothesis. Total RNAs, extracted from liver or lung tissue from 164 shrews collected from western North America during 1983–2007, were analyzed for ...


Phylogeny Of The Ciliate Family Psilotrichidae (Protista, Ciliophora), A Curious And Poorly-Known Taxon, With Notes On Two Algae-Bearing Psilotrichids From Guam, Usa, Xiaotian Luo, Jie A. Huang, Lifang Li, Weibo Song, William A. Bourland Jun 2019

Phylogeny Of The Ciliate Family Psilotrichidae (Protista, Ciliophora), A Curious And Poorly-Known Taxon, With Notes On Two Algae-Bearing Psilotrichids From Guam, Usa, Xiaotian Luo, Jie A. Huang, Lifang Li, Weibo Song, William A. Bourland

Biology Faculty Publications and Presentations

Background: The classification of the family Psilotrichidae, a curious group of ciliated protists with unique morphological and ontogenetic features, is ambiguous and poorly understood particularly due to the lack of molecular data. Hence, the systematic relationship between this group and other taxa in the subclass Hypotrichia remains unresolved. In this paper the morphology and phylogenetics of species from two genera of Psilotrichida are studied to shed new light on the phylogeny and species diversity of this group of ciliates.

Results: The 18S rRNA gene sequences of species from two psilotrichid genera were obtained. In the phylogenetic trees, the available psilotrichid ...


Dietary Plasticity In A Specialist Predator, The Gyrfalcon (Falco Rusticolus): New Insights Into Diet During Brood Rearing, Bryce W. Robinson, Travis L. Booms, Marc J. Bechard, David L. Anderson Jun 2019

Dietary Plasticity In A Specialist Predator, The Gyrfalcon (Falco Rusticolus): New Insights Into Diet During Brood Rearing, Bryce W. Robinson, Travis L. Booms, Marc J. Bechard, David L. Anderson

Biology Faculty Publications and Presentations

Climate and landscape change are expected to affect species’ distributions and interactions, with potentially harmful consequences for specialist predators. Availability of optimal prey can affect reproductive success in raptors, especially in the Arctic, where dramatic differences in prey availability occur both within and between years. However, behavioral responses of dietary specialist, resident predators such as Gyrfalcons (Falco rusticolus) to changes in prey availability remain poorly understood. To improve understanding of how climate-driven changes in prey availability may affect diet of avian predators in the Arctic, we characterized Gyrfalcon diet on the Seward Peninsula, Alaska, in 2014 and 2015 from images ...


Genotype Network Intersections Promote Evolutionary Innovation, Devin P. Bendixsen, James Collet, Bjørn Østman, Eric J. Hayden May 2019

Genotype Network Intersections Promote Evolutionary Innovation, Devin P. Bendixsen, James Collet, Bjørn Østman, Eric J. Hayden

Biology Faculty Publications and Presentations

Evolutionary innovations are qualitatively novel traits that emerge through evolution and increase biodiversity. The genetic mechanisms of innovation remain poorly understood. A systems view of innovation requires the analysis of genotype networks—the vast networks of genetic variants that produce the same phenotype. Innovations can occur at the intersection of two different genotype networks. However, the experimental characterization of genotype networks has been hindered by the vast number of genetic variants that need to be functionally analyzed. Here, we use high-throughput sequencing to study the fitness landscape at the intersection of the genotype networks of two catalytic RNA molecules (ribozymes ...


Differences Between Male And Female Elite Free-Style Wrestlers In The Effects Of “Set Up” On Leg Attack, Sho Ito, Larry Crawshaw, Kazuyuki Kanosue May 2019

Differences Between Male And Female Elite Free-Style Wrestlers In The Effects Of “Set Up” On Leg Attack, Sho Ito, Larry Crawshaw, Kazuyuki Kanosue

Biology Faculty Publications and Presentations

Leg attack is the most basic skill in free-style wrestling. Before executing a leg attack, balance and anticipation of the opponent must be disrupted. We defined this action as the “set up”. The aim of this study is knowledge about the effects of “set up” on the success rate of leg attacks, and answer to question: whether or not a gender difference exists in the use and effectiveness of “set ups” in the elite level of the wrestling matches. Material and Methods: We analyzed video recordings of 57 matches of male free-style wrestling seniors, 58 matches of female seniors, 60 ...


A Framework To Guide Undergraduate Education In Interdisciplinary Science, Brie Tripp, Erin E. Shortlidge May 2019

A Framework To Guide Undergraduate Education In Interdisciplinary Science, Brie Tripp, Erin E. Shortlidge

Biology Faculty Publications and Presentations

An expanded investment in interdisciplinary research has prompted greater demands to integrate knowledge across disciplinary boundaries. Vision and Change similarly made interdisciplinary expectations a key competency for undergraduate biology majors; however, we are not yet synchronized on the meaning of interdisciplinarity, making this benchmark difficult to meet and assess. Here, we discuss aspects of interdisciplinarity through a historical lens and address various institutional barriers to interdisciplinary work. In an effort to forge a unified path forward, we provide a working definition of interdisciplinary science derived from both the perspectives of science faculty members and scientific organizations. We leveraged the existing ...


Reduced-Impact Logging For Climate Change Mitigation (Ril-C) Can Halve Selective Logging Emissions From Tropical Forests, Anand Roopsind Apr 2019

Reduced-Impact Logging For Climate Change Mitigation (Ril-C) Can Halve Selective Logging Emissions From Tropical Forests, Anand Roopsind

Biology Faculty Publications and Presentations

Selective logging causes at least half of the emissions from tropical forest degradation. Reduced-impact logging for climate (RIL-C) is proposed as a way to maintain timber production while minimizing forest damage. Here we synthesize data from 61 coordinated field-based surveys of logging impacts in seven countries across the tropics. We estimate that tropical selective logging emitted 834 Tg CO2 in 2015, 6% of total tropical greenhouse gas emissions. Felling, hauling, and skidding caused 59%, 31%, and 10% of these emissions, respectively. We suggest that RIL-C incentive programs consider a feasible target carbon impact factor of 2.3 Mg emitted ...


Engineering Repressors With Coevolutionary Cues Facilitates Toggle Switches With A Master Reset, Rey P. Dimas, Xian-Li Jiang, Jose Alberto De La Paz, Faruck Morcos, Clement T.Y. Chan Apr 2019

Engineering Repressors With Coevolutionary Cues Facilitates Toggle Switches With A Master Reset, Rey P. Dimas, Xian-Li Jiang, Jose Alberto De La Paz, Faruck Morcos, Clement T.Y. Chan

Biology Faculty Publications and Presentations

Engineering allosteric transcriptional repressors containing an environmental sensing module (ESM) and a DNA recognition module (DRM) has the potential to unlock a combinatorial set of rationally designed biological responses. We demonstrated that constructing hybrid repressors by fusing distinct ESMs and DRMs provides a means to flexibly rewire genetic networks for complex signal processing. We have used coevolutionary traits among LacI homologs to develop a model for predicting compatibility between ESMs and DRMs. Our predictions accurately agree with the performance of 40 engineered repressors. We have harnessed this framework to develop a system of multiple toggle switches with a master OFF ...


Co-Expression Of Vegf And Il-6 Family Cytokines Is Associated With Decreased Survival In Her2 Negative Breast Cancer Patients: Subtype-Specific Il-6 Family Cytokine-Mediated Vegf Secretion, Ken Tawara, Hannah Scott, Jacqueline Emathinger, Alex Ide, Ryan Fox, Daniel Greiner, Dollie Lajoie, Danielle Hedeen, Madhuri Nandakumar, Andrew J. Oler, Ryan Holzer, Cheryl Jorcyk Feb 2019

Co-Expression Of Vegf And Il-6 Family Cytokines Is Associated With Decreased Survival In Her2 Negative Breast Cancer Patients: Subtype-Specific Il-6 Family Cytokine-Mediated Vegf Secretion, Ken Tawara, Hannah Scott, Jacqueline Emathinger, Alex Ide, Ryan Fox, Daniel Greiner, Dollie Lajoie, Danielle Hedeen, Madhuri Nandakumar, Andrew J. Oler, Ryan Holzer, Cheryl Jorcyk

Biology Faculty Publications and Presentations

Breast cancer cell-response to inflammatory cytokines such as interleukin-6 (IL-6) and oncostatin M (OSM) may affect the course of clinical disease in a cancer subtype-dependent manner. Furthermore, vascular endothelial growth factor A (VEGF) secretion induced by IL-6 and OSM may also be subtype-dependent. Utilizing datasets from Oncomine, we show that poor survival of invasive ductal carcinoma (IDC) breast cancer patients is correlated with both high VEGF expression and high cytokine or cytokine receptor expression in tumors. Importantly, epidermal growth factor receptor-negative (HER2-), but not HER2-positive (HER2+), patient survival is significantly lower with high tumor co-expression of VEGF and OSM, OSMRβ ...


Genome Sequences Of Three Cruciviruses Found In The Willamette Valley (Oregon), Ignacio De La Higuera, Ellis L. Torrance, Alyssa A. Pratt, George Kasun, Amberlee Maluenda, Kenneth M. Stedman Jan 2019

Genome Sequences Of Three Cruciviruses Found In The Willamette Valley (Oregon), Ignacio De La Higuera, Ellis L. Torrance, Alyssa A. Pratt, George Kasun, Amberlee Maluenda, Kenneth M. Stedman

Biology Faculty Publications and Presentations

Cruciviruses are single-stranded DNA (ssDNA) viruses whose genomes suggest the possibility of gene transfer between DNA and RNA viruses. Many crucivirus genome sequences have been found in metagenomic data sets, although no crucivirus has been isolated. Here, we present the complete genome sequences of three cruciviruses recovered from environmental samples from Oregon.


Disruption Of Cul3-Mediated Ubiquitination Causes Proximal Tubule Injury And Kidney Fibrosis, Turgay Saritas, Catherina A. Cuevas, Mohammed Z. Ferdaus, Christophe Kuppe, Rafael Kramann, Marcus J. Moeller, Jurgen Floege, Jeffrey Singer, James A. Mccormick Jan 2019

Disruption Of Cul3-Mediated Ubiquitination Causes Proximal Tubule Injury And Kidney Fibrosis, Turgay Saritas, Catherina A. Cuevas, Mohammed Z. Ferdaus, Christophe Kuppe, Rafael Kramann, Marcus J. Moeller, Jurgen Floege, Jeffrey Singer, James A. Mccormick

Biology Faculty Publications and Presentations

Cullin 3 (CUL3) is part of the ubiquitin proteasomal system and controls several cellular processes critical for normal organ function including the cell cycle, and Keap1/Nrf2 signaling. Kidney tubule-specific Cul3disruption causes tubulointerstitial fibrosis, but little is known about the mechanisms. Therefore, we tested the hypothesis that dysregulation of the cell cycle and Keap1/Nrf2 pathway play a role in initiating the kidney injury upon Cul3 disruption. Cul3 deletion increased expression of cyclin E and p21, associated with uncontrolled proliferation, DNA damage, and apoptosis, all of which preceded proximal tubule injury. The cdk2-cyclin E inhibitor roscovitine did not prevent ...


Despite Similar Perceptions And Attitudes, Postbaccalaureate Students Outperform In Introductory Biology And Chemistry Courses, Erin E. Shortlidge, Liz Rain-Griffith, Chloe Shelby, Gwen Shusterman, Jack Barbera Jan 2019

Despite Similar Perceptions And Attitudes, Postbaccalaureate Students Outperform In Introductory Biology And Chemistry Courses, Erin E. Shortlidge, Liz Rain-Griffith, Chloe Shelby, Gwen Shusterman, Jack Barbera

Biology Faculty Publications and Presentations

Embedding active learning is a common mechanism for meeting science, technology, engineering, and mathematics (STEM) education reform goals. Researchers have identified student benefits from such strategies, yet these benefits may not be universal for all students. We sought to identify how students at a nontraditional university perceive introductory biology and chemistry courses, and whether perceptions relate to course type, performance, or student status. We surveyed students (n = 601) using open-ended prompts regarding their perceptions of factors that impact their learning and interest, and about specific learning strategies. Generally, students did not differ in what influenced their learning or interest in ...


Cullin-3 Dependent Deregulation Of Actn1 Represents A New Pathogenic Mechanism In Nemaline Myopathy, Jordan Blondelle, Kavya Tallapaka, Jane T. Seto, Majid Ghassemian, Madison Clark, Jenni M. Laitila, Adam Bournazos, Jeffrey Singer, Stephan Lange Jan 2019

Cullin-3 Dependent Deregulation Of Actn1 Represents A New Pathogenic Mechanism In Nemaline Myopathy, Jordan Blondelle, Kavya Tallapaka, Jane T. Seto, Majid Ghassemian, Madison Clark, Jenni M. Laitila, Adam Bournazos, Jeffrey Singer, Stephan Lange

Biology Faculty Publications and Presentations

Nemaline myopathy is a congenital neuromuscular disorder characterized by muscle weakness, fiber atrophy, and presence of nemaline bodies within myofibers. However, understanding of the underlying pathomechanisms is lacking. Recently, mutations in KBTBD13, KLHL40, and KLHL41, three substrate adaptors for the E3 ubiquitin ligase Cullin-3, have been associated with early-onset nemaline myopathies. We hypothesized that deregulation of Cullin-3 and its muscle protein substrates may be responsible for disease development. Using Cullin-3–knockout mice, we identified accumulation of non-muscle α-actinins (ACTN1 and ACTN4) in muscles of these mice, which we also observed in patients with mutations in KBTBD13. Our data reveal that ...


A Fragment Of Apolipoprotein E4 Leads To The Downregulation Of A Cxorf56 Homologue, A Novel Er-Associated Protein, And Activation Of Bv2 Microglial Cells, Tanner B. Pollock, Jacob M. Mack, Noail F. Isho, Raquel J. Brown, Alexandra E. Oxford, Brad E. Morrison, Eric J. Hayden, Troy T. Rohn Jan 2019

A Fragment Of Apolipoprotein E4 Leads To The Downregulation Of A Cxorf56 Homologue, A Novel Er-Associated Protein, And Activation Of Bv2 Microglial Cells, Tanner B. Pollock, Jacob M. Mack, Noail F. Isho, Raquel J. Brown, Alexandra E. Oxford, Brad E. Morrison, Eric J. Hayden, Troy T. Rohn

Biology Faculty Publications and Presentations

Despite the fact that harboring the apolipoprotein E4 (APOE4) allele represents the single greatest risk factor for late-onset Alzheimer’s disease (AD), the exact mechanism by which apoE4 contributes to disease progression remains unknown. Recently, we demonstrated that a 151 amino-terminal fragment of apoE4 (nApoE41-151) localizes within the nucleus of microglia in the human AD brain, suggesting a potential role in gene expression. In the present study, we investigated this possibility utilizing BV2 microglia cells treated exogenously with nApoE41-151. The results indicated that nApoE41-151 leads to morphological activation of microglia cells through, at least in part, the ...


The Role Of Antarctica In Biogeographical Reconstruction: A Point Of View, Manuel De La Estrella, Sven Buerki, Thais Vasconcelos, Eve J. Lucas, Félix Forest Jan 2019

The Role Of Antarctica In Biogeographical Reconstruction: A Point Of View, Manuel De La Estrella, Sven Buerki, Thais Vasconcelos, Eve J. Lucas, Félix Forest

Biology Faculty Publications and Presentations

Premise of research. The opening of the Drake Passage in the Miocene (disconnecting Antarctica and South America and resulting in the establishment of the Circumpolar Current preventing warm waters from the north to reach the polar continent) has led to the formation of the ice sheets and the retreat of the temperate to tropical vegetation that had covered Antarctica for millions of years. With only two current native vascular plant species, Antarctica has been virtually ignored in biogeographical reconstructions and, when considered, only a posteriori invoked as a route of dispersal to reconcile inferred disjunct biogeographical patterns.

Methodology. Here, we ...


Dynamics Of Prochlorococcus Diversity And Photoacclimation During Short-Term Shifts In Water Column Stratification At Station Aloha, Anne W. Thompson, Ger Van Den Engh, Nathan A. Ahlgren, Kathleen Kouba, Samantha Ward, Samuel T. Wilson, David M. Karl Dec 2018

Dynamics Of Prochlorococcus Diversity And Photoacclimation During Short-Term Shifts In Water Column Stratification At Station Aloha, Anne W. Thompson, Ger Van Den Engh, Nathan A. Ahlgren, Kathleen Kouba, Samantha Ward, Samuel T. Wilson, David M. Karl

Biology Faculty Publications and Presentations

The cyanobacterium Prochlorococcus is the dominant phototroph in surface waters of the vast oligotrophic oceans, the foundation of marine food webs, and an important component of global biogeochemical cycles. The prominence of Prochlorococcus across the environmental gradients of the open ocean is attributed to its extensive genetic diversity and flexible chlorophyll physiology, enabling light capture over a wide range of intensities. What remains unknown is the balance between temporal dynamics of genetic diversity and chlorophyll physiology in the ability of Prochlorococcus to respond to a variety of short (approximately 1 day) and longer (months to year) changes in the environment ...


Resolving Authorship Disputes By Mediation And Arbitration, Zen Faulkes Nov 2018

Resolving Authorship Disputes By Mediation And Arbitration, Zen Faulkes

Biology Faculty Publications and Presentations

Background Disputes over authorship are increasing. This paper examines the options that researchers have in resolving authorship disputes. Discussions about authorship disputes often address how to prevent disputes but rarely address how to resolve them. Both individuals and larger research communities are harmed by the limited options for dispute resolution. Main body When authorship disputes arise after publication, most existing guidelines recommend that the authors work out the disputes between themselves. But this is unlikely to occur, because there are often large power differentials between team members, and institutions (e.g., universities, funding agencies) are unlikely to have authority over ...


Prohibiting Pet Crayfish Does Not Consistently Reduce Their Availability Online, Zen Faulkes Nov 2018

Prohibiting Pet Crayfish Does Not Consistently Reduce Their Availability Online, Zen Faulkes

Biology Faculty Publications and Presentations

The pet trade is a significant source of introductions of non-indigenous aquatic species, such as crayfish. To test whether legislation that regulates the ownership of ornamental animals for aquariums had the desired effect of reducing the availability of those pets, classified advertising websites were monitored for sales of crayfish in jurisdictions with and without legislation regulating the ownership of crayfish. Advertisements from Canadian provinces with legislation against owning crayfish were compared to provinces without such legislation. The population adjusted number of advertisements for crayfish, and number of distinct sellers of crayfish, was significantly lower in one of two provinces that ...


Modeling How Land Use Legacy Affects The Provision Of Ecosystem Services In Mediterranean Southern Spain, Juan Miguel Requena-Mullor, Cristina Quintas-Soriano, Jodi Brandt, Javier Cabello, Antonio J. Castro Nov 2018

Modeling How Land Use Legacy Affects The Provision Of Ecosystem Services In Mediterranean Southern Spain, Juan Miguel Requena-Mullor, Cristina Quintas-Soriano, Jodi Brandt, Javier Cabello, Antonio J. Castro

Biology Faculty Publications and Presentations

Land use decisions induce legacies that affect the welfare of future generations. Here, we present a spatial modeling approach for quantifying how past land use decisions influence provision of multiple ecosystem services(ESs) based on different land use trajectories. We modeled the effect of past land use changes on water regulation, soil protection and habitat quality in southern Spain, one of the most transformed areas of the Mediterranean region. We demonstrate a measurable influence of antecedent land use changes on the capacity of a given land use to provide ESs, and that the effect size can vary among different services ...


Dual Gain And Loss Of Cullin 3 Function Mediates Familial Hyperkalemic Hypertension, Ryan J. Cornelius, Chang Zhang, Kayla J. Erspamer, Larry N. Agbor, Curt D. Sigmund, Jeffrey Singer, Chao-Ling Yang, David H. Ellison Sep 2018

Dual Gain And Loss Of Cullin 3 Function Mediates Familial Hyperkalemic Hypertension, Ryan J. Cornelius, Chang Zhang, Kayla J. Erspamer, Larry N. Agbor, Curt D. Sigmund, Jeffrey Singer, Chao-Ling Yang, David H. Ellison

Biology Faculty Publications and Presentations

Familial hyperkalemic hypertension is caused by mutations in with-no-lysine kinases (WNKs) or in proteins that mediate their degradation, kelch-like 3 (KLHL3) and cullin 3 (CUL3). Although the mechanisms by which WNK and KLHL3 mutations cause the disease are now clear, the effects of the disease-causing CUL3Δ403-459 mutation remain controversial. Possible mechanisms, including hyperneddylation, altered ubiquitin ligase activity, decreased association with the COP9 signalosome (CSN), and increased association with and degradation of KLHL3 have all been postulated. Here, we systematically evaluated the effects of Cul3Δ403-459 using cultured kidney cells. We first identified that the catalytically active CSN subunit jun activation domain-binding ...


Random Genetic Drift And Selective Pressures Shaping The Blattabacterium Genome, Austin Alleman, Kate L. Hertweck, Srini Kambhampati Sep 2018

Random Genetic Drift And Selective Pressures Shaping The Blattabacterium Genome, Austin Alleman, Kate L. Hertweck, Srini Kambhampati

Biology Faculty Publications and Presentations

Estimates suggest that at least half of all extant insect genera harbor obligate bacterial mutualists. Whereas an endosymbiotic relationship imparts many benefits upon host and symbiont alike, the intracellular lifestyle has profound effects on the bacterial genome. The obligate endosymbiont genome is a product of opposing forces: genes important to host survival are maintained through physiological constraint, contrasted by the fixation of deleterious mutations and genome erosion through random genetic drift. The obligate cockroach endosymbiont, Blattabacterium – providing nutritional augmentation to its host in the form of amino acid synthesis – displays radical genome alterations when compared to its most recent free-living ...


Small Noncoding Rna Profiles Along Alternative Developmental Trajectories In An Annual Killifish, Amie L. Romney, Jason E. Podrabsky Sep 2018

Small Noncoding Rna Profiles Along Alternative Developmental Trajectories In An Annual Killifish, Amie L. Romney, Jason E. Podrabsky

Biology Faculty Publications and Presentations

Embryonic development of Austrofundulus limnaeus can occur along two phenotypic trajectories that are physiologically and biochemically distinct. Phenotype appears to be influenced by maternal provisioning based on the observation that young females produce predominately non-diapausing embryos and older females produce mostly diapausing embryos. Embryonic incubation temperature can override this pattern and alter trajectory. We hypothesized that temperature-induced phenotypic plasticity may be regulated by post-transcriptional modification via noncoding RNAs. As a first step to exploring this possibility, RNA-seq was used to generate transcriptomic profiles of small noncoding RNAs in embryos developing along the two alternative trajectories. We find distinct profiles of ...


Genetic Testing: Should I Get Tested For Alzheimer’S Risk?, Troy Rohn Aug 2018

Genetic Testing: Should I Get Tested For Alzheimer’S Risk?, Troy Rohn

Biology Faculty Publications and Presentations

Genetic testing is available to people who want to know if they carry a variant of a gene that confers susceptibility for Alzheimer’s. But knowing whether to get tested is hard.


Displacement Of The Transcription Factor B Reader Domain During Transcription Initiation, Stefan Dexl, Robert Reichelt, Katharina Kraatz, Sarah Schulz, Dina Grohmann, Michael S. Bartlett, Michael Thomm Aug 2018

Displacement Of The Transcription Factor B Reader Domain During Transcription Initiation, Stefan Dexl, Robert Reichelt, Katharina Kraatz, Sarah Schulz, Dina Grohmann, Michael S. Bartlett, Michael Thomm

Biology Faculty Publications and Presentations

Transcription initiation by archaeal RNA polymerase (RNAP) and eukaryotic RNAP II requires the general transcription factor (TF) B/ IIB. Structural analyses of eukaryotic transcription initiation complexes locate the B-reader domain of TFIIB in close proximity to the active site of RNAP II. Here, we present the first crosslinking mapping data that describe the dynamic transitions of an archaeal TFB to provide evidence for structural rearrangements within the transcription complex during transition from initiation to early elongation phase of transcription. Using a highly specific UV-inducible crosslinking system based on the unnatural amino acid para-benzoyl-phenylalanine allowed us to analyze contacts of ...


Resolving The Anomaly Of Lomatium Anomalum: Discovery Of A New Species In Southwestern Idaho (U.S.A.), Lomatium Andrusianum (Apiaceae), Mckayla Stevens, Donald H. Mansfield, James F. Smith, Mary Ann E. Feist Jul 2018

Resolving The Anomaly Of Lomatium Anomalum: Discovery Of A New Species In Southwestern Idaho (U.S.A.), Lomatium Andrusianum (Apiaceae), Mckayla Stevens, Donald H. Mansfield, James F. Smith, Mary Ann E. Feist

Biology Faculty Publications and Presentations

Apparent polyphyly within the unresolved clade of Lomatium (Apiaceae) containing L. triternatum, L. anomalum, L. thompsonii, and L. packardiae suggests conflict among current taxonomic classification schemes. To recover this clade and more clearly define species boundaries, we examined populations of L. anomalum from three geographic regions in Idaho and adjacent Oregon. Using phylogenetic, morphological, and ecological data, we conclude that the L. anomalum complex currently circumscribes multiple species. Phylogenetic analysis of the nuclear ribosomal ITS and ETS, and cpDNA rpl32-trnLUAG, rps-16 intron, trnD-trnT, ndhA intron, and psbA-trnH recovered populations from the Boise foothills as a distinct, monophyletic clade. Principal Components ...


Follow The Rain? Environmental Drivers Of Tyrannus Migration Across The New World, Maggie P. Macpherson, Alex E. Jahn, Michael T. Murphy, Daniel H. Kim, Victor R. Cueto, Diego T. Tuero, Elliot D. Hill Jul 2018

Follow The Rain? Environmental Drivers Of Tyrannus Migration Across The New World, Maggie P. Macpherson, Alex E. Jahn, Michael T. Murphy, Daniel H. Kim, Victor R. Cueto, Diego T. Tuero, Elliot D. Hill

Biology Faculty Publications and Presentations

Predictable seasonal changes in resources are thought to drive the timing of annual animal migrations; however, we currently understand little about which environmental cues or resources are tracked by different migratory bird species across the planet. Understanding which environmental cues or resources birds track in multiple migratory systems is a prerequisite to developing generalizable conservation plans for migratory birds in a changing global environment. Within the New World, climatic differences experienced by Nearctic–Neotropical migratory (NNM; i.e. breed in North America and spend the nonbreeding period in the Neotropics) and Neotropical austral migratory (NAM; i.e. breed and spend ...


The Evolution Of Anti-Bat Sensory Illusions In Moths, Juliette J. Rubin, Chris A. Hamilton, Christopher J.W. Mcclure, Brad A. Chadwell, Akito Y. Kawahara, Jesse R. Barber Jul 2018

The Evolution Of Anti-Bat Sensory Illusions In Moths, Juliette J. Rubin, Chris A. Hamilton, Christopher J.W. Mcclure, Brad A. Chadwell, Akito Y. Kawahara, Jesse R. Barber

Biology Faculty Publications and Presentations

Prey transmit sensory illusions to redirect predatory strikes, creating a discrepancy between what a predator perceives and reality. We use the acoustic arms race between bats and moths to investigate the evolution and function of a sensory illusion. The spinning hindwing tails of silk moths (Saturniidae) divert bat attack by reflecting sonar to create a misleading echoic target. We characterized geometric morphometrics of moth hindwings across silk moths, mapped these traits onto a new, robust phylogeny, and found that elaborated hindwing structures have converged on four adaptive shape peaks. To test the mechanism underlying these anti-bat traits, we pit bats ...