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Full-Text Articles in Life Sciences

Molecular Dynamics Analysis Of Apolipoprotein-D - Lipid Hydroperoxide Interactions: Mechanism For Selective Oxidation Of Met-93, Aaron J. Oakley, Surabhi Bhatia, Heath Ecroyd, Brett Garner Dec 2012

Molecular Dynamics Analysis Of Apolipoprotein-D - Lipid Hydroperoxide Interactions: Mechanism For Selective Oxidation Of Met-93, Aaron J. Oakley, Surabhi Bhatia, Heath Ecroyd, Brett Garner

Heath Ecroyd

Background: Recent studies suggest reduction of radical-propagating fatty acid hydroperoxides to inert hydroxides by interaction with apolipoprotein-D (apoD) Met93 may represent an antioxidant function for apoD. The nature and structural consequences of this selective interaction are unknown. Methodology/Principal Findings: Herein we used molecular dynamics (MD) analysis to address these issues. Longtimescale simulations of apoD suggest lipid molecules are bound flexibly, with the molecules free to explore multiple conformations in a binding site at the entrance to the classical lipocalin ligand-binding pocket. Models of 5s- 12s- and 15s hydroperoxyeicosatetraenoic acids were created and the lipids found to wrap around Met93 ...


The Analysis Of Pattern Change In Intron Sequences, Jinda Kongcharoen, Yan-Xia Lin, Rachel Caldwell, Yiren Yang, Ren Zhang Nov 2012

The Analysis Of Pattern Change In Intron Sequences, Jinda Kongcharoen, Yan-Xia Lin, Rachel Caldwell, Yiren Yang, Ren Zhang

Associate Professor Yan-Xia Lin

The Generalized Bernoulli Modeling approach is used to analyze the pattern change in intron sequences of a model plant species Arabidopsis thaliana. The influence of the intron length and the number of GC on the intron sequence pattern changes is examined. Two other gene properties, the gene expression level and the protein function encoded are also assessed. Among the random sampled intron sequences,10.71% of them have been identified to have sequence pattern change. Our study shows that the number of GC and the intron length significantly influence the intron pattern change while the gene expression level and the ...


Direct Detection Of Additives And Degradation Products From Polymers By Liquid Extraction Surface Analysis Employing Chip-Based Nanospray Mass Spectrometry, Martin Paine, Phillip Barker, Shane A. Maclaughlin, Todd W. Mitchell, Stephen J. Blanksby Oct 2012

Direct Detection Of Additives And Degradation Products From Polymers By Liquid Extraction Surface Analysis Employing Chip-Based Nanospray Mass Spectrometry, Martin Paine, Phillip Barker, Shane A. Maclaughlin, Todd W. Mitchell, Stephen J. Blanksby

Stephen Blanksby

Rationale: Polymer-based surface coatings in outdoor applications experience accelerated degradation due to exposure to solar radiation, oxygen and atmospheric pollutants. These deleterious agents cause undesirable changes to the polymers aesthetic and mechanical properties reducing its lifetime. The use of antioxidants such as hindered amine light stabilisers (HALS) retard these degradative processes, however, mechanisms for HALS action and polymer degradation are poorly understood. Methods: Detection of the hindered amine light stabiliser (HALS) TINUVIN®123 (bis (1-octyloxy-2,2,6,6-tetramethyl-4-piperidyl) sebacate) and the polymer degradation products directly from a polyester-based coil coating was achieved by liquid extraction surface analysis (LESA) coupled to ...


A Petrological, Mineralogical And Geochemical Analysis Of Listwaenite Alteration At Spring Creek Bingara In The Great Serpentinite Belt, New England, Nsw, E Holcroft, Solomon Buckman, I Neuss Sep 2012

A Petrological, Mineralogical And Geochemical Analysis Of Listwaenite Alteration At Spring Creek Bingara In The Great Serpentinite Belt, New England, Nsw, E Holcroft, Solomon Buckman, I Neuss

Solomon Buckman Dr.

No abstract provided.


Analysis Of The Costs Of A Large Prevention Trial, Nicole Urban, Steven Self, Larry Kessler, Ross Prentice, Maureen Henderson, Donald Iverson, Donovan Thompson, David Byar, William Insull, Sherwood Gorbach, C Clifford, Susan Goldman Jun 2012

Analysis Of The Costs Of A Large Prevention Trial, Nicole Urban, Steven Self, Larry Kessler, Ross Prentice, Maureen Henderson, Donald Iverson, Donovan Thompson, David Byar, William Insull, Sherwood Gorbach, C Clifford, Susan Goldman

Don C. Iverson

Total direct costs of the Women's Health Trial (WHT), alarge multicenter preventiontrial, were reduced by more than 50% by means of research costanalysis conducted during the trial design phase. The unit costs of specific trial activities were estimated so that total direct costs of the trial could be predicted from design parameters. The relative costs of screening, treatment, and follow-up, and the fixed costs associated with each clinical center in a multicenter preventiontrial were taken into account. Direct costs of the WHT were reduced from $195 million to $95 million by refinement of the trial protocol, selection of an ...


An Overview And Analysis Of The Health Style Campaign, Mary Davis, Donald Iverson Jun 2012

An Overview And Analysis Of The Health Style Campaign, Mary Davis, Donald Iverson

Don C. Iverson

In 1981, the Office of Health Information and Health Promotion of the U.S. Department of Health and Human Services launched a national health promotion media campaign titled Health Style. The purposes of the Health Style campaign were: (1) to increase public awareness of the effects of life-style on health; (2) to enable persons to assess which life-style changes would be most conducive to their health; (3) to stimulate information-seeking behavior and; (4) to foster the development of local health promotion activities and referral networks. The campaign was implemented in nine test communities across the United States. This article: (1 ...


Disease Awareness Advertisements In Australian Magazines: An Analysis Of Content And Compliance, Danika Hall, Sandra C. Jones, Donald C. Iverson Jun 2012

Disease Awareness Advertisements In Australian Magazines: An Analysis Of Content And Compliance, Danika Hall, Sandra C. Jones, Donald C. Iverson

Don C. Iverson

In Australia, Direct to Consumer Advertising (DTCA) of prescription medicine is prohibited; however pharmaceutical companies can communicate directly with consumers via Disease Awareness Advertising (DAA). DAA can contain information about a disease including treatment information, but cannot mention the name of a particular product or brand. DAA is currently regulated by the industry body Medicines Australia (MA). In the current study, content analysis methodology was used to determine the extent and nature of DAA in popular Australian women’s magazines which were monitored for 12 months. Findings relating to the use of visual appeals in the imagery and rational appeals ...


Content Analysis Of Disease Awareness Advertisements In Popular Australian Women's Magazines, Danika V. Hall, Sandra C. Jones, Donald C. Iverson Jun 2012

Content Analysis Of Disease Awareness Advertisements In Popular Australian Women's Magazines, Danika V. Hall, Sandra C. Jones, Donald C. Iverson

Don C. Iverson

Objective: To examine the nature of disease awareness advertising (DAA). Design: Therapeutic advertisements in six popular Australian women’s magazines were monitored between April 2006 and March 2007. A subset of advertisements was included in the study based on criteria derived from a definition of DAA. Unique advertisements were analysed by four independent coders. Main outcome measures: Types of advertisements and their sponsors, the types of disease information present, and the persuasive techniques utilised. Results: Of 711 advertisements identified, 60 met the inclusion criteria for DAA, and 30 of these were unique. Over one-third of the advertisements were classified as ...


Clinician Optimism: Development And Psychometric Analysis Of A Scale For Mental Health Clinicians, Mitchell K. Byrne, Nichole L. Sullivan, Stephen J. Elsom May 2012

Clinician Optimism: Development And Psychometric Analysis Of A Scale For Mental Health Clinicians, Mitchell K. Byrne, Nichole L. Sullivan, Stephen J. Elsom

Mitchell K Byrne

Clinician optimism is an important factor in achieving treatment outcomes in psychotherapy. Currently there are no measures of mental health clinician optimism which report substantial psychometric validation. This study sought to assesses the validity and reliability of the Therapeutic Optimism Scale (TOS). 223 mental health clinicians working in a range of clinical settings were administered the TOS and convergent and discriminate validity were established. Test-retest reliability was established over a period of one month. The Therapeutic Optimism Scale was found to achieve acceptable reliability (Chronbach's alpha = .68) and yielded consistent scores over a one month period (r = .68, p ...


Essays In Realism: Analysis And Discussion, Nigel Mackay, Agnes Petocz Feb 2012

Essays In Realism: Analysis And Discussion, Nigel Mackay, Agnes Petocz

Nigel Mackay

No abstract provided.