Open Access. Powered by Scholars. Published by Universities.®

Life Sciences Commons

Open Access. Powered by Scholars. Published by Universities.®

Selected Works

Analysis

2007

Articles 1 - 1 of 1

Full-Text Articles in Life Sciences

Model-Based Compartmental Analysis Indicates A Reduced Mobilization Of Hepatic Vitamin A During Inflammation In Rats, Sin H. Gieng, Michael H. Green, Joanne B. Green, Francisco J. Rosales Jan 2007

Model-Based Compartmental Analysis Indicates A Reduced Mobilization Of Hepatic Vitamin A During Inflammation In Rats, Sin H. Gieng, Michael H. Green, Joanne B. Green, Francisco J. Rosales

John Sin H. Gieng

Vitamin A (VA) kinetics was studied in rats with marginal VA stores before, during, and after inflammation. Rats received orally [11,12-3H(N)]retinol ([3H]VA; day 0), and inflammation was induced on day 21 with lipopolysacchride (LPS) for 3 days (n = 5) or recombinant human interleukin-6 (rhIL-6) for 7 days (n = 5). Both the fraction of [3H]VA and retinol concentrations in plasma were reduced significantly by LPS or rhIL-6. Compartmental analysis using the Windows version of Simulation, Analysis, and Modeling software was applied to group mean data, and non-steady-state models were developed. After absorption ...