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Full-Text Articles in Life Sciences

Prevalence And Effects Of Mycotoxins On Poultry Health And Performance, And Recent Development In Mycotoxin Counteracting Strategies, G. R. Murugesan, D Ledoux, K Naehrer, F Berthiller, T Applegate, B Grenier, T Phillips, G Schatzmayr Dec 2014

Prevalence And Effects Of Mycotoxins On Poultry Health And Performance, And Recent Development In Mycotoxin Counteracting Strategies, G. R. Murugesan, D Ledoux, K Naehrer, F Berthiller, T Applegate, B Grenier, T Phillips, G Schatzmayr

G. R. Murugesan

Extensive research over the last couple of decades has made it obvious that mycotoxins are commonly prevalent in majority of feed ingredients. A worldwide mycotoxin survey in 2013 revealed 81 % of around 3,000 grain and feed samples analyzed had at least one mycotoxin which was higher than the ten-year average (from 2004 to 2013) of 76% in a total of 25,944 samples. The considerable increase in the number of positive samples in 2013 may be due to the improvements in detection methods and their sensitivity. The recently developed liquid chromatography coupled to (tandem) mass spectrometry allows the inclusion ...


Analysis Of The Costs Of A Large Prevention Trial, Nicole Urban, Steven Self, Larry Kessler, Ross Prentice, Maureen Henderson, Donald Iverson, Donovan Thompson, David Byar, William Insull, Sherwood Gorbach, C Clifford, Susan Goldman Jun 2012

Analysis Of The Costs Of A Large Prevention Trial, Nicole Urban, Steven Self, Larry Kessler, Ross Prentice, Maureen Henderson, Donald Iverson, Donovan Thompson, David Byar, William Insull, Sherwood Gorbach, C Clifford, Susan Goldman

Don C. Iverson

Total direct costs of the Women's Health Trial (WHT), alarge multicenter preventiontrial, were reduced by more than 50% by means of research costanalysis conducted during the trial design phase. The unit costs of specific trial activities were estimated so that total direct costs of the trial could be predicted from design parameters. The relative costs of screening, treatment, and follow-up, and the fixed costs associated with each clinical center in a multicenter preventiontrial were taken into account. Direct costs of the WHT were reduced from $195 million to $95 million by refinement of the trial protocol, selection of an ...


An Overview And Analysis Of The Health Style Campaign, Mary Davis, Donald Iverson Jun 2012

An Overview And Analysis Of The Health Style Campaign, Mary Davis, Donald Iverson

Don C. Iverson

In 1981, the Office of Health Information and Health Promotion of the U.S. Department of Health and Human Services launched a national health promotion media campaign titled Health Style. The purposes of the Health Style campaign were: (1) to increase public awareness of the effects of life-style on health; (2) to enable persons to assess which life-style changes would be most conducive to their health; (3) to stimulate information-seeking behavior and; (4) to foster the development of local health promotion activities and referral networks. The campaign was implemented in nine test communities across the United States. This article: (1 ...


Analysis Of The Mechanism By Which Calcium Negatively Regulates The Tyrosine Phosphorylation Cascade Associated With Sperm Capacitation, Mark Baker, Louise Hethrington, Heath Ecroyd, Shaun Roman, Robert Aitken Dec 2011

Analysis Of The Mechanism By Which Calcium Negatively Regulates The Tyrosine Phosphorylation Cascade Associated With Sperm Capacitation, Mark Baker, Louise Hethrington, Heath Ecroyd, Shaun Roman, Robert Aitken

Heath Ecroyd

The capacitation of mammalian spermatozoa involves the activation of a cAMP-mediated signal transduction pathway that drives tyrosine phosphorylation via mechanisms that are unique to this cell type. Controversy surrounds the impact of extracellular calcium on this process, with positive and negative effects being recorded in independent publications. We clearly demonstrate that the presence of calcium in the external medium decreases tyrosine phosphorylation in both human and mouse spermatozoa. Under these conditions, a rise in intracellular pH was recorded, however, this event was not responsible for the observed changes in phosphotyrosine expression. Rather, the impact of calcium on tyrosine phosphorylation in ...