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Selected Works

Jibin Zhang

Fayoumi

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Full-Text Articles in Life Sciences

Pag 2017 Poster _ Jibin Zhang.Pdf, Jibin Zhang, Michael G. Kaiser, Melissa S. Herrmann, Rodrigo A. Gallardo, David A. Bunn, Terra R. Kelly, Jack C. M. Dekkers, Huaijun Zhou, Susan J. Lamont Jan 2017

Pag 2017 Poster _ Jibin Zhang.Pdf, Jibin Zhang, Michael G. Kaiser, Melissa S. Herrmann, Rodrigo A. Gallardo, David A. Bunn, Terra R. Kelly, Jack C. M. Dekkers, Huaijun Zhou, Susan J. Lamont

Jibin Zhang

Velogenic Newcastle disease virus (NDV) causes global economic losses in the poultry industry. Although proper vaccination does prevent outbreaks of ND, genetic selection for enhanced resistance to NDV offers a complementary approach to disease prevention. Understanding the gene expression changes induced by ND infection will help to elucidate mechanisms of host resistance and susceptibility.
Two distinct and highly inbred chicken lines - Fayoumi and Leghorn - were studied as relatively ND-resistant and susceptible models, respectively. Equal numbers of birds from each line were inoculated with LaSota strain NDV (or saline control) through nasal and ocular routes at 21 days of age. Viral ...


Rna-Seq Analysis Reveals Distinct Splenic Response Of Two Chickens Lines To Newcastle Disease Virus, Jibin Zhang, Michael G. Kaiser, Melissa S. Herrmann, Rodrigo A. Gallardo, David A. Bunn, Huaijun Zhou, Susan J. Lamont May 2016

Rna-Seq Analysis Reveals Distinct Splenic Response Of Two Chickens Lines To Newcastle Disease Virus, Jibin Zhang, Michael G. Kaiser, Melissa S. Herrmann, Rodrigo A. Gallardo, David A. Bunn, Huaijun Zhou, Susan J. Lamont

Jibin Zhang

Newcastle disease virus (NDV) is an infectious virus in domestic chickens and is endemic in many countries. It has caused huge economic losses worldwide, especially in developing countries where the chickens and eggs are a primary source of economic income and family nutrition for the rural poor. Due to continuous evolution of NDV and unreliable vaccine production and distribution in developing countries, vaccine cannot prevent recurrent outbreaks of Newcastle disease. Therefore, breeding for NDV resistant chickens is a sustainable approach for alleviating rural poverty and food insecurity.
To identify critical genes regulating NDV resistance, an RNA-seq approach was undertaken with ...