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Graduate Theses and Dissertations

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Full-Text Articles in Life Sciences

Springs Of The Arabian Peninsula: Historical Trends, Current Status And Human Impact In Saudi Arabia, Oman And Jordan, Kamal M. Aljohani Dec 2019

Springs Of The Arabian Peninsula: Historical Trends, Current Status And Human Impact In Saudi Arabia, Oman And Jordan, Kamal M. Aljohani

Graduate Theses and Dissertations

This research was conducted to update previous studies of the springs of the Arabian Peninsula (Saudi Arabia, Oman and Jordan). Approach: 76 springs were surveyed in between March and July 2018: 15 Saudi Arabia, 41 Oman and 20 Jordan to ascertain the current status, water quality and zooplankton benthos and fish communities. Investigation of the changes of biota and chemical parameters downstream from the springs source in Saudi Arabia. Results: Mercury exceeded the WHO and USEPA maximum contaminant level (MCL) in 63 of 76 springs, Aluminum exceeded MCL in 8 of 76 springs, and both were the common dissolved heavy ...


Constituent Partitioning Consensus Docking Models And Application In Drug Discovery, Rainer Metcalf Nov 2019

Constituent Partitioning Consensus Docking Models And Application In Drug Discovery, Rainer Metcalf

Graduate Theses and Dissertations

This work expounds on some of the current computational tools and programs available and the best practices associated with their use. A high-level introduction, intended for both novices and the semi-experienced, focusing on the more common programs used in scientific literature is the scope of this topic. Both classical and quantum techniques are described. Classical methodologies include Molecular Dynamics, Monte Carlo, energy minimization methods, molecular docking, low-mode, and homology modeling. Quantum chemistry techniques are also discussed encompassing Hartree-Fock, Post-Hartree-Fock theories, and Density Functional Theory along with associated basis sets.

Along with established methodologies, novel theoretical methods are introduced for furthering ...


The Peculiar Nature Of Florida’S Sandhill Wetlands, Ponds & Lakes— Their Ecohydrology, Relationship With The Regional Aquifer & Importance Within The Landscape., Renae Starr Nowicki Nov 2019

The Peculiar Nature Of Florida’S Sandhill Wetlands, Ponds & Lakes— Their Ecohydrology, Relationship With The Regional Aquifer & Importance Within The Landscape., Renae Starr Nowicki

Graduate Theses and Dissertations

This dissertation explores the ecohydrology of Florida’s peculiar and poorly studied sandhill wetland and water features, particularly those located in west-central Florida. The primary research goals include: compilation and summarization of the available ecohydrologic information for features across Florida; comparison of water level and water geochemistry data between sandhill wetlands and waters and the regional aquifer to provide evidence of regional hydrologic control; and use of geophysical applications to examine the hydraulic connections between sandhill wetlands and waters and the regional aquifer.

From this research, a natural history of sandhill wetland and water ecohydrology is presented, highlighting: the differences ...


Amyloid Protein Aggregation And Associated Toxicity, Chamani A. Niyangoda Nov 2019

Amyloid Protein Aggregation And Associated Toxicity, Chamani A. Niyangoda

Graduate Theses and Dissertations

Amyloidosis is a group of diseases in which amyloid fibrils accumulate and deposit into plaques and intracellular inclusions which lead to disruption of the tissue architecture and function. Most of the amyloid diseases are incurable due to a lack of understanding of the amyloid formation, as well as associated toxicity. My research work is focused on three different aspects of amyloid aggregation.

The aim of the first project is to investigate the potential use of deep-blue autofluorescence (dbAF) as an intrinsic optical probe to study amyloid self-assembly. This novel fluorescence signal is excited at the long wavelength edge of the ...


Untapped Potential Of Gorgonian Octocorals For Detecting Environmental Change In Biscayne National Park, Florida, Usa, Selena A. Kupfner Johnson Nov 2019

Untapped Potential Of Gorgonian Octocorals For Detecting Environmental Change In Biscayne National Park, Florida, Usa, Selena A. Kupfner Johnson

Graduate Theses and Dissertations

One consequence of dramatic stony-coral loss has been recognition that gorgonian octocorals (Anthozoa: Octocorallia) have emerged among the dominant reef fauna. However, gorgonians are notoriously difficult to field-identify and consequently have been underrepresented in most monitoring efforts resulting in a lack of long-term data. The rich diversity of habitats, close proximity to the urban center of Miami, and connectivity to other areas of Florida have made Biscayne National Park an active location for reef research since its establishment in 1968. As such, a plethora of data (e.g., museum specimen and species abundance data) has been collected and stored in ...


A Novel Cytokine Response Modulatory Function Of Mek Inhibitors Mediates Therapeutic Efficacy, Mengyu Xie Nov 2019

A Novel Cytokine Response Modulatory Function Of Mek Inhibitors Mediates Therapeutic Efficacy, Mengyu Xie

Graduate Theses and Dissertations

Despite the recent success of immune-checkpoint blockade therapy for late-stage non-small cell lung cancer (NSCLC), lung cancer is still the leading cause of cancer deaths worldwide. One of the most important characteristics of lung cancer in therapeutic decision-making are the targetable molecules, including EGFR, ALK, BRAF, and MEK. The excitement of immune-checkpoint blockade therapy has triggered concerted efforts that focus on exploring combinations of immune checkpoint therapy with other approved therapeutic regimens aiming at further augmenting positive outcomes and survival. However, the lack of understanding of underlying mechanisms and evidence-based clinical testing has hindered the progress to a cure. Hence ...


Investigating Among-Individual Growth Heterogeneity In Longleaf Pine: Advancing Dendrochronological Approaches, Jamie E. Munn Nov 2019

Investigating Among-Individual Growth Heterogeneity In Longleaf Pine: Advancing Dendrochronological Approaches, Jamie E. Munn

Graduate Theses and Dissertations

Within a population, individuals frequently differ in the rate at which they grow, and this rate can be impacted by both genetic differences and abiotic factors. Often, dendrochronology is used to elucidate growth trends based on climate or other factors. This dissertation explores new statistical approaches to dendrochronological research.

First, I created a chronology for a population of longleaf pine (Pinus palustris P. Mill.) individuals in a southwest Florida sandhill community. I then used generalized linear mixed models to investigate the effects of fire frequency, year, tree age and size, and elevation on variation in radial growth heterogeneity. I then ...


Targeting Bacterial Resistance And Cancer Metastasis: A Structure Based Approach, Kyle Galen Kroeck Nov 2019

Targeting Bacterial Resistance And Cancer Metastasis: A Structure Based Approach, Kyle Galen Kroeck

Graduate Theses and Dissertations

Current research in pharmaceutical development commonly utilizes a profusion of methods in molecular modeling in order to probe intricate biological problems. Many original and promising compounds have been identified and developed by integrating experimental and computational methods. Structural biology utilizes many different research techniques including x-ray crystallography, NMR, and electron microscopy in order to develop molecular models of macromolecules that are of biological interest. Such techniques can be used in conjunction with molecular docking, which utilizes those molecular models in order to target macromolecules of therapeutic interest by computationally analyzing the conformations adopted by ligands upon interaction with a desired ...


Modeling Of Interaction Of Ions With Ether- And Ester-Linked Phospholipids, Matthew W. Saunders Oct 2019

Modeling Of Interaction Of Ions With Ether- And Ester-Linked Phospholipids, Matthew W. Saunders

Graduate Theses and Dissertations

Phospholipids are present in all parts of cells and are used in many signalling and struc- tural roles. As structural molecules they act as the main component of cellular membranes. Bilayer properties are heavily influenced by the structure of their component polar lipids, and different lipids are found in different organisms. A distinguishing feature of Archaeal plasma membranes is that their phospholipids contain ether-links, as opposed to bacterial and eukaryotic plasma membranes where phospholipids primarily contain ester-links. In our work we examine the effects of salt on bilayer structure in the case of both ester- and ether-linked lipid bilayers. We ...


Design And Implementation Of Degenerate Qpcr/Qrt-Pcr Primers To Detect Microbial Nitrogen Metabolism In Wastewater And Wastewater-Related Samples, Ryan F. Keeley Aug 2019

Design And Implementation Of Degenerate Qpcr/Qrt-Pcr Primers To Detect Microbial Nitrogen Metabolism In Wastewater And Wastewater-Related Samples, Ryan F. Keeley

Graduate Theses and Dissertations

Nitrogen cycling processes can be tracked using quantitative Polymerase Chain Reaction (qPCR) to determine the presence and qReverse Transcriptase-PCR (qRT-PCR) to determine expression of key genes, or ‘biological markers’, for nitrogen metabolism. Nitrification is catalyzed in part, by two enzymes: ammonia monooxygenase (AMO; NH3 NH2OH) and nitrite oxidoreductase (NXR; NO2- NO3-). For denitrification, four enzymes act sequentially: nitrate reductase (NAR/NAP; NO3- NO2-), nitrite reductase (NIR; NO2- NO), nitric oxide reductase (NOR; NO  N2O), and nitrous oxide reductase (NOS; N2O  N2). A principle of wastewater treatment (WWT) is to remove excess nitrogen by taking advantage of natural nitrogen cycling or ...


Hybrid Fusion Protein For Inhibition Of Multiple Proteases For Chronic Wound Healing, Graham L. Strauss Jul 2019

Hybrid Fusion Protein For Inhibition Of Multiple Proteases For Chronic Wound Healing, Graham L. Strauss

Graduate Theses and Dissertations

Many diseases display a multitude of relevant factors that contribute to the persistence of the disease and difficulty treating it. The multifactorial characteristics of some diseases lead to the requirement of combination of treatments in order to restore health. The latter may necessitate the mixing of treatments, medications, and therapeutics to first halt the disease, then assist the human body in returning itself to a state of normality. For example, chronic wounds exhibit this multifactor characteristic in which there exist many factors that lead to the body’s inability to properly heal in a timely manner. This presents a further ...


Modulations Of Lipid Membranes Caused By Antimicrobial Agents And Helix 0 Of Endophilin, Nawal Kishore Khadka Jul 2019

Modulations Of Lipid Membranes Caused By Antimicrobial Agents And Helix 0 Of Endophilin, Nawal Kishore Khadka

Graduate Theses and Dissertations

Understanding the cellular membrane interaction with membrane active biomolecules and antimicrobial agents provides an insight in their working mechanism. Here, we studied the effect of antimicrobial agents; a recently developed peptidomimetics E107-3 and colistin as well as the N-terminal helix H0, of Endophilin A1 on the lipid bilayer.

It is important to discern the interaction mechanism of antimicrobial peptides with lipid membranes in battling multidrug resistant bacterial pathogens. We study the modification of structural and mechanical properties with a recently reported peptidomimetic on lipid bilayer. The compound referred to as E107-3 is synthesized based on the acylated reduced amide scaffold ...


A Small Rna And Dna Binding Protein Contribute To Biofilm Development In Bartonella Henselae, Udoka Okaro Jul 2019

A Small Rna And Dna Binding Protein Contribute To Biofilm Development In Bartonella Henselae, Udoka Okaro

Graduate Theses and Dissertations

A biofilm, which is associated with 80% of chronic infections in humans, is formed when bacteria aggregate, attach to a substrate and secrete a matrix protecting the bacteria from host cell defenses and antibiotics. Bartonella henselae (B. henselae) is the causative agent of cat scratch disease, persistent bacteremia, and one of the most frequently reported causes of blood-culture negative endocarditis (BCNE) in patients. The ability of B. henselae to adhere to the heart valve, form a biofilm and vegetation to cause endocarditis increases the morbidity and mortality rate in infected patients. The presence of a trimeric autotransporter adhesin (TAA) called ...


The Distribution And Biogeochemistry Of Subtropical Intertidal Microbial Mats, Bert D. Anderson Jun 2019

The Distribution And Biogeochemistry Of Subtropical Intertidal Microbial Mats, Bert D. Anderson

Graduate Theses and Dissertations

Microbial mats have played an important role in the carbon (C) and nutrient cycles since the Archean Eon and modern mats are important contributors to the biogeochemistry of intertidal wetlands. Microbial mats are flat assemblages of microbes that are currently found in many unvegetated habitats globally. Intertidal salt pans are a common habitat for microbial mats, however little is known about the distribution of microbial mats within the intertidal landscape. Understanding the spatial distribution of microbial mats is critical to developing quantitative estimates of the impacts of microbial mats on their ecosystems. We photographically measured the presence and density of ...


An Investigation Of The Effects Of The Parasitic Nematode Aplectana Hamatospicula On The Performance And Behavior Of Cuban Treefrogs (Osteopilus Septentrionalis), Kerri Surbaugh Jun 2019

An Investigation Of The Effects Of The Parasitic Nematode Aplectana Hamatospicula On The Performance And Behavior Of Cuban Treefrogs (Osteopilus Septentrionalis), Kerri Surbaugh

Graduate Theses and Dissertations

Parasitic infections are ubiquitous in nature, and host-parasite dynamics can have powerful effects on wildlife populations. Many species have evolved behavioral responses to infection that can help mitigate damage from parasites. Anorexia is a common response to infection observed throughout the animal kingdom. Reducing nutrient intake can help shift host resources from digestion to immunity, as well as limit resources available to parasites. Reduced feeding can weaken the host, but in some host-parasite interactions, this cost is less than that of maintaining an infection. Here, I describe an experiment aimed to explore the effects of the parasitic nematode Aplectana hamatospicula ...


Habitat Suitability Index Model Of The Florida Sandhill Crane (Grus Canadensis Pratensis) In West-Central Florida, Courtney E. Buck Jun 2019

Habitat Suitability Index Model Of The Florida Sandhill Crane (Grus Canadensis Pratensis) In West-Central Florida, Courtney E. Buck

Graduate Theses and Dissertations

The Florida Sandhill Crane (Grus canadensis pratensis) is a state threatened endemic subspecies of the Sandhill Crane (Nesbitt & Tacha, 1997). With a population that was estimated at a maximum of 5,000 individuals in 2003 (Nesbitt & Hatchitt, 2008), it is imperative to identify potentially viable habitats, as Florida is rapidly developing. This research develops a Habitat Suitability Index model to determine unsuitable to optimally suitable habitat locations throughout west-central Florida. To do so, six suitability variables based on the crane’s life history were evaluated: Potential nesting area, immediate nesting area, wetland coverage, foraging area, brooding area, and road proximity ...


Evolutionary Dynamics Of Influenza Type B In The Presence Of Vaccination: An Ecological Study, Lindsey J. Fiedler Jun 2019

Evolutionary Dynamics Of Influenza Type B In The Presence Of Vaccination: An Ecological Study, Lindsey J. Fiedler

Graduate Theses and Dissertations

Understanding the evolutionary dynamics of influenza type B in human hosts is a public health concern as we strive to minimize the disease burden in seasonal epidemics. Vaccination is considered the best defense against contracting influenza, and everyone over the age of 6 months is advised to get vaccinated before each season. The effect that vaccine-acquired immunity has on the evolution of influenza B remains unclear. In the U.S., vaccine-uptake is irregular across the states, and the differing coverages present an opportunity to study how vaccination influences viral evolution. This thesis analyzes the evolutionary patterns of influenza B in ...


Contribution Of Retrotransposons To Breast Cancer Malignancy, Isaac D. Raplee Apr 2019

Contribution Of Retrotransposons To Breast Cancer Malignancy, Isaac D. Raplee

Graduate Theses and Dissertations

The components contributing to cancer progression, especially the transition from early to invasive are unknown. Consequently, the biological reasons are unclear as to why some patients diagnosed with atypia and ductal carcinoma in situ (DCIS) never progress into invasive breast cancer. The “one gene at a time” approach does not sufficiently predict progression. To elucidate the early stage progression to invasive ductal cancer, expression signature of transcripts and transposable elements in micropunched samples of formalin-fixed, paraffin embedded (FFPE) tissue was conducted. A bioinformatics pipeline to analyze poor quality, short reads (>36 nts) from RNA-Seq data was created to compare the ...


A Retrospective Study Of The Opioid Epidemic And Fentanyl Related Overdose Fatality Cases In A Florida West Coast Medical Examiner District Population, Anne Terese Powell Apr 2019

A Retrospective Study Of The Opioid Epidemic And Fentanyl Related Overdose Fatality Cases In A Florida West Coast Medical Examiner District Population, Anne Terese Powell

Graduate Theses and Dissertations

Opioids are scheduled by the propensity for misuse and abuse with a high rate of dependency and risk of fatal overdose. Opioids can be divided into different classes, including, natural, synthetic, and semi-synthetic. Opiates are naturally occurring and come directly from the opium poppy plant; whereas the semi synthetics opioids are chemical modifications of the poppy plant. Synthetic opioids attach to the opioid receptor but contain no part of the poppy plant. The increased variety and frequency in opioid prescriptions contributed to an opioid epidemic in the United States which is still on going.

According to the CDC, the opioid ...


The Modified Synchronization Modulation Technique Revealed Mechanisms Of Na,K-Atpase, Pengfei Liang Apr 2019

The Modified Synchronization Modulation Technique Revealed Mechanisms Of Na,K-Atpase, Pengfei Liang

Graduate Theses and Dissertations

The Na/K pumps are essential for living system and widely expressed in all eukaryotic cell membranes. By actively transporting sodium ions out of and potassium ions into the plasma membrane, Na/K pumps creates both an electrical and a chemical gradient across the plasma membrane, which are crucial for maintaining membrane potential, cell volume, and secondary active transporting of other solutes, etc.

Previously, oscillating electric field with a frequency close to the mean physiological turnover rate was used to synchronize and modulate the Na/K pump molecules. Results showed that the turnover rate of Na/K pumps can be ...


Genomics And Transcriptomics Approaches To Understanding Drug Resistance Mechanisms In The Malaria Parasite Plasmodium Falciparum, Justin Allan Gibbons Mar 2019

Genomics And Transcriptomics Approaches To Understanding Drug Resistance Mechanisms In The Malaria Parasite Plasmodium Falciparum, Justin Allan Gibbons

Graduate Theses and Dissertations

The malaria parasite Plasmodium falciparum is responsible for about 500,000 deaths a year and is evolving resistance to the front-line treatment of artemisinin-based combination therapy. Resistance is currently confined to South East Asia, however millions of lives will be at risk if resistance spreads to Africa. Understanding the mechanism of resistance to artemisinins would aid containment strategies to prevent the spread of artemisinin resistance. There is also an urgent need to accelerate drug discovery since drug resistance has already been documented to all existing antimalarials. Here, I report on our efforts to understand the function of the gene k13 ...


Role Of Oncogenic Protein Kinase C-Iota In Melanoma Progression; A Study Based On Atypical Protein Kinase-C Inhibitors, Wishrawana Sarathi Bandara Ratnayake Mar 2019

Role Of Oncogenic Protein Kinase C-Iota In Melanoma Progression; A Study Based On Atypical Protein Kinase-C Inhibitors, Wishrawana Sarathi Bandara Ratnayake

Graduate Theses and Dissertations

Irrespective of plentiful efforts to enhance primary prevention and early detection, the number of melanoma cases in the United States has increased steadily over the past 30 years, thus greatly affecting public health and the economy. We have investigated the effects of five novel aPKC inhibitors; 2-acetyl-1,3-cyclopentanedione (ACPD), 3,4-Diaminonaphthalene-2,7-disulfonic acid (DNDA), [4-(5-amino-4-carbamoylimidazol-1-yl)-2,3-dihydroxycyclopentyl] methyl dihydrogen phosphate (ICA-1T) along with its nucleoside analog 5-amino-1-((1R,2S,3S,4R)-2,3-dihydroxy-4-methylcyclopentyl)-1H-imidazole-4-carboxamide (ICA-1S) and 8-hydroxy-1,3,6-naphthalenetrisulfonic acid (ζ-Stat) on cell proliferation, apoptosis, migration and invasion of two malignant melanoma cell lines compared to normal melanocyte cell ...


Psychological Responses To High-Intensity Interval Training Exercise: A Comparison Of Ungraded Running And Graded Walking, Abby Fleming Mar 2019

Psychological Responses To High-Intensity Interval Training Exercise: A Comparison Of Ungraded Running And Graded Walking, Abby Fleming

Graduate Theses and Dissertations

This study investigated the effects of ungraded running and graded walking as modalities of HIIT on enjoyment, perceived exertion, and affect. 29 healthy males and females (aged 23.3 ± 5.1) volunteered to participate in the study. Participants completed six visits to the laboratory: the first was a medical screening to ensure safety of the participants. For the second and third visits, participants completed two maximal treadmill exercise tests, one running and one walking. On the fourth visit, the speed needed for the run HIIT (running speed: 6.9 ± 1.2mph) and the grade needed for the walk HIIT (walking ...


Genome Size And Host Specialization In Parasites, Nicholas Theodore Ogburn Mar 2019

Genome Size And Host Specialization In Parasites, Nicholas Theodore Ogburn

Graduate Theses and Dissertations

In parasites, there are several examples of changes in genome size linked to a parasitic lifestyle—with some species having greatly reduced or expanded genome sizes relative to free-living non-parasitic relatives. What is unknown is whether there is correlated evolution between genome size and host specialization, and whether there is a generalizable framework in predicting genome size evolution in parasites using their genetic architecture and host use ecology. Here, I tested whether genome size of 96 eukaryotic parasites across a wide variety of taxa correlates with host specialization, quantified by the number and phylogenetic relatedness of host species they parasitize ...


Conserved Glycine Residues Control Transient Helicity And Disorder In The Cold Regulated Protein, Cor15a, Oluwakemi Sowemimo Mar 2019

Conserved Glycine Residues Control Transient Helicity And Disorder In The Cold Regulated Protein, Cor15a, Oluwakemi Sowemimo

Graduate Theses and Dissertations

COR15A is a cold regulated disordered protein from Arabidopsis thaliana that contributes to freezing tolerance in plants by protecting membranes. It belongs to the (LEA) Late Embryogenesis Abundant group of proteins that accumulate during the later stage of seed development and are expressed in various parts of the plant. During freezing-induced cellular dehydration, COR15A transitions from a disordered structure to a mostly α-helical structure that binds and stabilizes chloroplast membranes when cells dehydrate due to freezing. We hypothesize that increasing the transient α-helicity of COR15A under normal conditions will increase its ability to bind and protect chloroplast membranes when cells ...


Medical Decision Making Among Individuals With A Variant Of Uncertain Significance In A Hereditary Cancer Gene And Those With A Chek2 Pathogenic Variant, Deanna J. Almanza Mar 2019

Medical Decision Making Among Individuals With A Variant Of Uncertain Significance In A Hereditary Cancer Gene And Those With A Chek2 Pathogenic Variant, Deanna J. Almanza

Graduate Theses and Dissertations

Despite national guidelines, women with a BRCA VUS or CHEK2 pathogenic variant are choosing to have risk-reducing surgeries such as bilateral mastectomies which are not aligned with their level of cancer risk based on genetic test results alone. Semi-structured telephone interviews were conducted with 6 women with a BRCA VUS and 12 with a CHEK2 pathogenic variant exploring the factors influencing their decision-making process when considering medical management options. Patients from a cancer registry agreed to a recorded telephone interview. Coding was performed using the main constructs from the Ottawa Patient Decision Guide including: knowledge, uncertainty, values, and support. Iterative ...


Species Abundance, Spatial And Vertical Distributionsof Large Heteropods (Pterotracheidae And Carinariidae)In The Northern Gulf Of Mexico, Kristine A. Clark Mar 2019

Species Abundance, Spatial And Vertical Distributionsof Large Heteropods (Pterotracheidae And Carinariidae)In The Northern Gulf Of Mexico, Kristine A. Clark

Graduate Theses and Dissertations

A description of species abundance, richness and distribution, and eye size of heteropod molluscs from the families Pterotracheidae and Carinariidae in the oligotrophic ecosystem of the northern Gulf of Mexico (GOM) is described based on discrete-depth sampling protocols. The collections were comprised from two midwater sampling programs conducted sequentially after the 2010 Deepwater Horizon oil spill (DWHOS): the Offshore Nekton Sampling and Analysis Program (ONSAP, 2011) and the Deep Pelagic Nekton Dynamics of the Gulf of Mexico (DEEPEND, 2015-2018). Study materials from DEEPEND were collected during the initial five cruises of 2015-2017. These programs collected over 3,495 heteropods in ...


Biochemical And Proteomic Approaches To Determine The Impact Level Of Each Step Of The Supply Chain On Tomato Fruit Quality, Robert T. Madden Mar 2019

Biochemical And Proteomic Approaches To Determine The Impact Level Of Each Step Of The Supply Chain On Tomato Fruit Quality, Robert T. Madden

Graduate Theses and Dissertations

Fresh fruits and vegetables (FFVs) are the most frequently wasted foods because of their perishability and handling requirements. However, there is a lack of information on how much each step of the supply chain impacts FFVs quality, particularly on tomatoes, and what measures need to be taken for an immediate and effective impact on waste reduction. There is also no information on how the supply chain affects the proteome of the tomato and what proteins are differentially regulated by the most impactful steps of the supply chain. The objectives of the work presented on this thesis were to evaluate the ...


Investigating Student Conceptual Understanding Of Structure And Function By Using Formative Assessment And Automated Scoring Models, Kelli Patrice Carter Mar 2019

Investigating Student Conceptual Understanding Of Structure And Function By Using Formative Assessment And Automated Scoring Models, Kelli Patrice Carter

Graduate Theses and Dissertations

There has been a call from the national community of biologists and biology educators to increase biological literacy of undergraduate students, including understanding and application of core concepts. The structure and function relationship is a core concept identified by the wider biology community and by physiology faculty. Understanding of the core concept structure and function across multiple levels of organization may promote biological literacy. My research focused on the development of formative written assessment tools to provide insight into student understanding of structure and function in anatomy and physiology.

In chapter two I developed automated scoring tools to facilitate the ...


A Feasibility Analysis Of A Pilot Study Comparing Prenatal Genetic Service Delivery Outcomes Using The Self-Determination Theory, Lindsey N. Victoria Mar 2019

A Feasibility Analysis Of A Pilot Study Comparing Prenatal Genetic Service Delivery Outcomes Using The Self-Determination Theory, Lindsey N. Victoria

Graduate Theses and Dissertations

Genetic counselors, along with the National Society of Genetic Counselors, desire evidence-based research and data assessing the value of genetic counseling in genetic service delivery. This pilot study was designed to gather data about genetic counseling outcomes as well as analyze the feasibility of a study looking at new genetic outcome measures in the prenatal setting. Implementation of the methods used for data collection were evaluated by analysis of the appropriateness, acceptability, feasibility, fidelity, and adoption of the research protocol at three sites. We found that there is a hierarchy between implementation outcomes and it may be necessary to satisfy ...