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Life Sciences Commons

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Faculty Publications

Bioinformatics

Bioinformatics

2009

Articles 1 - 1 of 1

Full-Text Articles in Life Sciences

Integrative Disease Classification Based On Cross-Platform Microarray Data, C.-C. Liu, Jianjun Hu, M. Kalakrishnan, H. Huang, X. J. Zhou Jan 2009

Integrative Disease Classification Based On Cross-Platform Microarray Data, C.-C. Liu, Jianjun Hu, M. Kalakrishnan, H. Huang, X. J. Zhou

Faculty Publications

Background

Disease classification has been an important application of microarray technology. However, most microarray-based classifiers can only handle data generated within the same study, since microarray data generated by different laboratories or with different platforms can not be compared directly due to systematic variations. This issue has severely limited the practical use of microarray-based disease classification.

Results

In this study, we tested the feasibility of disease classification by integrating the large amount of heterogeneous microarray datasets from the public microarray repositories. Cross-platform data compatibility is created by deriving expression log-rank ratios within datasets. One may then compare vectors of log-rank ...