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University of Nebraska - Lincoln

Dissertations, Theses, & Student Research in Food Science and Technology

Candida

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Full-Text Articles in Life Sciences

Studies Of Debaryomyces Hansenii Killer Toxin And Its Effect On Pathogenic Bloodstream Candida Isolates, Rhaisa A. Crespo Ramírez Apr 2016

Studies Of Debaryomyces Hansenii Killer Toxin And Its Effect On Pathogenic Bloodstream Candida Isolates, Rhaisa A. Crespo Ramírez

Dissertations, Theses, & Student Research in Food Science and Technology

Candida species are normal commensal organisms found in the skin, mouth, and gastrointestinal and genitourinary tracts of humans. Candida albicans is a normal component of the gut flora, and the oral and genital cavities. However, this organism is an opportunistic pathogen and it is one of the most frequently isolated species from patients with nosocomial fungal infections. Candida infections have grown in recent years due to antimycotics resistance and the extensive use of antibiotics. This has pushed scientists to look for alternative therapeutic agents to treat fungal infections.

Yeasts can produce toxic proteins called “mycocins” or “killer toxins” that can ...


Debaryomyces Hansenii: A Foodborne Yeast That Produces Anti-Candida Killer Toxin, Nabaraj Banjara Apr 2014

Debaryomyces Hansenii: A Foodborne Yeast That Produces Anti-Candida Killer Toxin, Nabaraj Banjara

Dissertations, Theses, & Student Research in Food Science and Technology

Candida yeasts are commensal members of the gastrointestinal, mucosal, oral and vaginal microbiota. Candida albicans and C. tropicalis can be found as a part of the normal human commensal flora, especially in all sections of the gastrointestinal tract. However, when the host defense system and microbiota are disturbed, Candida can become pathogenic and cause severe infection or candidiasis. Antifungal drugs used to treat candidiasis have been shown to result in treatment failures due to drug toxicity and/or development of resistance during long term antifungal therapy and, in recent years, the incidence of Candida infections has increased dramatically due to ...