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University of Massachusetts Medical School

Cellular and Molecular Physiology

2019

Homeostasis

Articles 1 - 2 of 2

Full-Text Articles in Life Sciences

Sptlc1 Is Essential For Myeloid Differentiation And Hematopoietic Homeostasis, Velayoudame Parthibane, Usha Acharya, Jairaj K. Acharya Nov 2019

Sptlc1 Is Essential For Myeloid Differentiation And Hematopoietic Homeostasis, Velayoudame Parthibane, Usha Acharya, Jairaj K. Acharya

Open Access Articles

Serine palmitoyltransferase (SPT) long-chain base subunit 1 (SPTLC1) is 1 of the 2 main catalytic subunits of the SPT complex, which catalyzes the first and rate-limiting step of sphingolipid biosynthesis. Here, we show that Sptlc1 deletion in adult bone marrow (BM) cells results in defective myeloid differentiation. In chimeric mice from noncompetitive BM transplant assays, there was an expansion of the Lin- c-Kit+ Sca-1+ compartment due to increased multipotent progenitor production, but myeloid differentiation was severely compromised. We also show that defective biogenesis of sphingolipids in the endoplasmic reticulum (ER) leads to ER stress that affects myeloid differentiation. Furthermore, we ...


Non-Equilibrium Critical Dynamics Of Bursts In Theta And Delta Rhythms As Fundamental Characteristic Of Sleep And Wake Micro-Architecture, Jilin W. J. L. Wang, Fabrizio Lombardi, Xiyun Zhang, Christelle Anaclet, Plamen Ch. Ivanov Nov 2019

Non-Equilibrium Critical Dynamics Of Bursts In Theta And Delta Rhythms As Fundamental Characteristic Of Sleep And Wake Micro-Architecture, Jilin W. J. L. Wang, Fabrizio Lombardi, Xiyun Zhang, Christelle Anaclet, Plamen Ch. Ivanov

Open Access Articles

Origin and functions of intermittent transitions among sleep stages, including short awakenings and arousals, constitute a challenge to the current homeostatic framework for sleep regulation, focusing on factors modulating sleep over large time scales. Here we propose that the complex micro-architecture characterizing the sleep-wake cycle results from an underlying non-equilibrium critical dynamics, bridging collective behaviors across spatio-temporal scales. We investigate theta and delta wave dynamics in control rats and in rats with lesions of sleep-promoting neurons in the parafacial zone. We demonstrate that intermittent bursts in theta and delta rhythms exhibit a complex temporal organization, with long-range power-law correlations and ...