Open Access. Powered by Scholars. Published by Universities.®

Life Sciences Commons

Open Access. Powered by Scholars. Published by Universities.®

University of Massachusetts Medical School

Cellular and Molecular Physiology

Zhang Lab Publications

Articles 1 - 1 of 1

Full-Text Articles in Life Sciences

Regulation Of Senescence In Cancer And Aging, Yahui Kong, Hang Cui, Charusheila Ramkumar, Hong Zhang Jan 2011

Regulation Of Senescence In Cancer And Aging, Yahui Kong, Hang Cui, Charusheila Ramkumar, Hong Zhang

Zhang Lab Publications

Senescence is regarded as a physiological response of cells to stress, including telomere dysfunction, aberrant oncogenic activation, DNA damage, and oxidative stress. This stress response has an antagonistically pleiotropic effect to organisms: beneficial as a tumor suppressor, but detrimental by contributing to aging. The emergence of senescence as an effective tumor suppression mechanism is highlighted by recent demonstration that senescence prevents proliferation of cells at risk of neoplastic transformation. Consequently, induction of senescence is recognized as a potential treatment of cancer. Substantial evidence also suggests that senescence plays an important role in aging, particularly in aging of stem cells. In ...