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University of Massachusetts Medical School

Cellular and Molecular Physiology

Meyers Primary Care Institute Publications and Presentations

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Whole Blood Gene Expression And Atrial Fibrillation: The Framingham Heart Study, Honghuang Lin, Xiaoyan Yin, Kathryn L. Lunetta, Josee Dupuis, David D. Mcmanus, Steven A. Lubitz, Jared W. Magnani, Roby Joehanes, Peter J. Munson, Martin G. Larson, Daniel Levy, Patrick T. Ellinor, Emelia J. Benjamin May 2014

Whole Blood Gene Expression And Atrial Fibrillation: The Framingham Heart Study, Honghuang Lin, Xiaoyan Yin, Kathryn L. Lunetta, Josee Dupuis, David D. Mcmanus, Steven A. Lubitz, Jared W. Magnani, Roby Joehanes, Peter J. Munson, Martin G. Larson, Daniel Levy, Patrick T. Ellinor, Emelia J. Benjamin

Meyers Primary Care Institute Publications and Presentations

BACKGROUND: Atrial fibrillation (AF) involves substantial electrophysiological, structural and contractile remodeling. We hypothesize that characterizing gene expression might uncover important pathways related to AF.

METHODS AND RESULTS: We performed genome-wide whole blood transcriptomic profiling (Affymetrix Human Exon 1.0 ST Array) of 2446 participants (mean age 66 +/- 9 years, 55% women) from the Offspring cohort of Framingham Heart Study. The study included 177 participants with prevalent AF, 143 with incident AF during up to 7 years follow up, and 2126 participants with no AF. We identified seven genes statistically significantly up-regulated with prevalent AF. The most significant gene, PBX1 (P ...