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University of Massachusetts Medical School

Cellular and Molecular Physiology

Lawrence Lab Publications

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Higher-Order Unfolding Of Satellite Heterochromatin Is A Consistent And Early Event In Cell Senescence, Eric C. Swanson, Benjamin J. Manning, Hong Zhang, Jeanne B. Lawrence Dec 2013

Higher-Order Unfolding Of Satellite Heterochromatin Is A Consistent And Early Event In Cell Senescence, Eric C. Swanson, Benjamin J. Manning, Hong Zhang, Jeanne B. Lawrence

Lawrence Lab Publications

Epigenetic changes to chromatin are thought to be essential to cell senescence, which is key to tumorigenesis and aging. Although many studies focus on heterochromatin gain, this work demonstrates large-scale unraveling of peri/centromeric satellites, which occurs in all models of human and mouse senescence examined. This was not seen in cancer cells, except in a benign senescent tumor in vivo. Senescence-associated distension of satellites (SADS) occurs earlier and more consistently than heterochromatin foci formation, and SADS is not exclusive to either the p16 or p21 pathways. Because Hutchinson Guilford progeria syndrome patient cells do not form excess heterochromatin, the ...