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The Evolution Of Reduced Microbial Killing, Jan A.C. Vriezen Dr., Michael Valliere, Margaret A. Riley Dr. Jan 2009

The Evolution Of Reduced Microbial Killing, Jan A.C. Vriezen Dr., Michael Valliere, Margaret A. Riley Dr.

Jan A.C. Vriezen Dr.

Bacteria engage in a never-ending arms race in which they compete for limited resources and niche space. The outcome of this intense interaction is the evolution of a powerful arsenal of biological weapons. Perhaps the most studied of these are colicins, plasmid-based toxins produced by and active against Escherichia coli. The present study was designed to explore the molecular responses of a colicin-producing strain during serial transfer evolution. What evolutionary changes occur when colicins are produced with no target present? Can killing ability be maintained in the absence of a target? To address these, and other, questions, colicinogenic strains and ...