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SelectedWorks

Statistics and Probability

2010

Discrete data; Genomics; Single Nucleotide Polymorphisms; Stability; Test Statistics

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Full-Text Articles in Life Sciences

Discrete Nonparametric Algorithms For Outlier Detection With Genomic Data, Debashis Ghosh Jan 2010

Discrete Nonparametric Algorithms For Outlier Detection With Genomic Data, Debashis Ghosh

Debashis Ghosh

In high-throughput studies involving genetic data such as from gene expression mi- croarrays, dierential expression analysis between two or more experimental conditions has been a very common analytical task. Much of the resulting literature on multiple comparisons has paid relatively little attention to the choice of test statistic. In this article, we focus on the issue of choice of test statistic based on a special pattern of dierential expression. The approach here is based on recasting multiple comparisons procedures for assessing outlying expression values. A major complication is that the resulting p-values are discrete; some theoretical properties of sequential testing ...