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Full-Text Articles in Life Sciences

Satpdb: A Database Of Structurally Annotated Therapeutic Peptides, Sandeep Singh Oct 2015

Satpdb: A Database Of Structurally Annotated Therapeutic Peptides, Sandeep Singh

Sandeep Singh

SATPdb (http://crdd.osdd.net/raghava/satpdb/) is a database of structurally annotated therapeutic peptides, curated from 22 public domain peptide databases/datasets including 9 of our own. The current version holds 19192 unique experimentally validated therapeutic peptide sequences having length between 2 and 50 amino acids. It covers peptides having natural, non-natural and modified residues. These peptides were systematically grouped into 10 categories based on their major function or therapeutic property like 1099 anticancer, 10585 antimicrobial, 1642 drug delivery and 1698 antihypertensive peptides. We assigned or annotated structure of these therapeutic peptides using structural databases (Protein Data Bank) and ...


Mohammed Madai: Significance Of The Earth Day, Ubuntu Institute Students Apr 2015

Mohammed Madai: Significance Of The Earth Day, Ubuntu Institute Students

Ubuntu Institute Students

One may ask himself: What is the significance of Earth Day? Mohammed Madai explores the significance of this day to our daily lives


Effect Of Fibre Blend Ratios On Yarn Properties, Innovative Research Publications Irp India, A. Ghosh, M. Raihan Apr 2015

Effect Of Fibre Blend Ratios On Yarn Properties, Innovative Research Publications Irp India, A. Ghosh, M. Raihan

Innovative Research Publications IRP India

Yarn properties can be altered through blending fibres. According to the requirement different properties can be achieved by different blending ratios. Among the different blends cotton and polyester, cotton and wool, wool and acrylic, cotton and nylon, jute and acrylic, cotton and rayon etc are common. Flax and polyester has been a popular blend now-adays and depicts excellent properties than their individual yarn properties. Different proportion of flax and polyester has been tested to observe the yarn properties and it is found that polyester was perfectly fits with low proportion of flax. Their blends with specific ratios exhibit excellent properties ...


Study On The Demolition Waste Management In Malaysia Construction Industry, Innovative Research Publications Irp India, Gunalaan Vasudevan Mar 2015

Study On The Demolition Waste Management In Malaysia Construction Industry, Innovative Research Publications Irp India, Gunalaan Vasudevan

Innovative Research Publications IRP India

The Malaysia construction industry generates a large quantity of construction and demolition waste nowadays. In the handbook for demolition work only comprised small portion of demolition waste management. It is important to study and determine the ways to provide a practical guide for the professional in the building industry about handling the demolition waste. In general, demolition defined as tearing down or wrecking of structural work or architectural work of the building and other infrastructures work such as road, bridge and etc. It’s a common misconception that demolition is nothing more than taking down a structure and carrying the ...


Study On The Strategy Of Ghs System In Taiwan, Innovative Research Publications Irp India, Study On The Strategy Of Ghs System In Taiwan,Kun-Yuan Chuang,Jo-Ming Tseng,Teh-Sheng Su, Fang-Chen Lin Feb 2015

Study On The Strategy Of Ghs System In Taiwan, Innovative Research Publications Irp India, Study On The Strategy Of Ghs System In Taiwan,Kun-Yuan Chuang,Jo-Ming Tseng,Teh-Sheng Su, Fang-Chen Lin

Innovative Research Publications IRP India

The “Globally Harmonized System of Classification and Labeling of Chemicals” (GHS) not only provides a unified system for dealing with the labeling of intrinsic materials and compound chemicals but also furnishes hazard information to the contingency personnel, work site workforce, transportation workforce and consumers for the prevention of acute and chronic health impairments as well as ecological hazards. Since 2008, the GHS has gradually been observed internationally to substitute the classification and labeling of hazardous substances, the Material Safety Data Sheet (MSDS), and relevant regulations on hazardous chemicals which are currently used by many countries; substantial influences have been seen ...


Freshwater Habitats And Fishing Activities In The Buriganga River, Dhaka, Bangladesh., Md.Muzammel Hossain, Mohammad Abdul Baki Nov 2014

Freshwater Habitats And Fishing Activities In The Buriganga River, Dhaka, Bangladesh., Md.Muzammel Hossain, Mohammad Abdul Baki

Md.Muzammel Hossain

The Buriganga River has served as the central artery to economic life in Dhaka city for centuries. But Buriganga River is the most polluted river in Bangladesh. During the study period (December 2012 to November 2013), we directly observed freshwater habitats and fishing activities by boat-base survey from china-Bangladesh Friendship Bridge (90°26´12'' E and 23°40´25''N) to Amin bazar Bridge (90°20´12''E and 23°46´25''N) in the Buriganga River. Freshwater habitats were observed at babu bazar, kamrangichar, kholamora ghat and shadar ghat throughout the year in the River. Different types of fishes ...


Lead Exposure From Aluminum Cookware In Cameroon, Jeffrey D. Weidenhamer, Peter A. Lobunski, Gilbert Kuepouo, Rebecca W. Corbin, Perry Gottesfeld Oct 2014

Lead Exposure From Aluminum Cookware In Cameroon, Jeffrey D. Weidenhamer, Peter A. Lobunski, Gilbert Kuepouo, Rebecca W. Corbin, Perry Gottesfeld

Jeffrey D. Weidenhamer

Blood lead levels have decreased following the removal of lead from gasoline in most of the world. However, numerous recent studies provide evidence that elevated blood lead levels persist in many low and middle-income countries around the world at much higher prevalence than in the more developed countries. One potential source of lead exposure that has not been widely investigated is the leaching of lead from artisanal aluminum cookware, which is commonly used in the developing world. Twenty-nine samples of aluminum cookware and utensils manufactured by local artisans in Cameroon were collected and analyzed for their potential to release lead ...


Ligand-Receptor Interactions For Supramolecular Disassembly With Applications In Screening And Drug Delivery, Diego F. Amado Torres May 2014

Ligand-Receptor Interactions For Supramolecular Disassembly With Applications In Screening And Drug Delivery, Diego F. Amado Torres

Diego Amado Torres

Proteins have the capacity to bind specific sets of compounds known as ligands, these are small molecules with a recurrent theme in their molecular design that is a characteristic exploited here to (i) identify particular affinities of small molecules for proteins with the aim of using them as ligands, inhibitors, or targeting moieties in more complex systems by means of a methodology that screens small molecules based on protein affinity; (ii) decorate a self-assembling supramolecular system at different positions, making it responsive to a complementary protein with the aim of exploring differences in disassembly and sensitivity of the release of ...


Disaster Management: What India Can Learn From Other Countries, Vivek Kumar Srivastava Dr. May 2014

Disaster Management: What India Can Learn From Other Countries, Vivek Kumar Srivastava Dr.

Vivek Kumar Srivastava Dr.

Present paper analyses the Indian response to disasters. It is also a policy paper as it provides the ways which can be useful in mitigating the disaster risks.


Boldine Protects Endothelial Function In Hyperglycemia-Induced Oxidative Stress Through An Antioxidant Mechanism, Dharmani Devi A/P Murugan Feb 2013

Boldine Protects Endothelial Function In Hyperglycemia-Induced Oxidative Stress Through An Antioxidant Mechanism, Dharmani Devi A/P Murugan

Dharmani Devi A/P Murugan

Increased oxidative stress is involved in the pathogenesis and progression of diabetes. Antioxidants are therapeutically beneficial for oxidative stress-associated diseases. Boldine ([s]-2,9-dihydroxy-1,10-dimethoxyaporphine) is a major alkaloid present in the leaves and bark of the boldo tree (Peumus boldus Molina), with known an antioxidant activity. This study examined the protective effects of boldine against high glucose-induced oxidative stress in rat aortic endothelial cells (RAEC) and its mechanisms of vasoprotection related to diabetic endothelial dysfunction. In RAEC exposed to high glucose (30 mM) for 48 h, pre-treatment with boldine reduced the elevated ROS and nitrotyrosine formation, and preserved nitric ...


Could You Repeat That Please? Forty-Five Years Of Testing Pesticides On People, Barbara R. Leiterman Esq. Jan 2013

Could You Repeat That Please? Forty-Five Years Of Testing Pesticides On People, Barbara R. Leiterman Esq.

Barbara R. Leiterman Esq.

Little has been published in the literature about pesticide experiments conducted on human subjects. Yet there were at least twenty-two tests between 1967 and 2011 in which people were intentionally exposed to specific doses of pesticides. Almost all of these experiments violated scientific ethics and human rights. This article aims to describe those tests and their shortcomings, and explore the laws and regulations that incentivize such human experimentation. Ironically, as the public desire for pesticide safety increases, so does the industry’s motivation to test pesticides on people. Bringing these pesticide experiments to light, expanding the public discourse on the ...


An Assessment Of The Effects Of Desertification In Yobe State, Nigeria, Jibril Musa Phd Dec 2012

An Assessment Of The Effects Of Desertification In Yobe State, Nigeria, Jibril Musa Phd

Confluence Journal Environmental Studies (CJES), Kogi State University, Nigeria

Desertification is one of the most serious environmental and socio-economic problems of our time. Desertification describes circumstances of land degradation in arid, semi-arid and dry sub-humid regions resulting from the climatic variation and human activities. The fundamental goal of this thesis was to assess the effects of desertification in Yobe State, Nigeria. The present threat of desertification in the sahel has reached an alarming stage where crops cultivation and animal rearing/grazing are no more productive, soil has lost its nutrient/fertility, various infrastructure had given way because of windstorm from the neighbouring Niger Republic and sand dunes had taken ...


Using Remote Sensing Data To Improve Rice Production In Kutigi, Niger State, Nigeria, Jibril Musa Phd, M B. Yunusa Dec 2012

Using Remote Sensing Data To Improve Rice Production In Kutigi, Niger State, Nigeria, Jibril Musa Phd, M B. Yunusa

Confluence Journal Environmental Studies (CJES), Kogi State University, Nigeria

This research work looked in the used of Remote Sensing to improve Agricultural production in Kutigi, Niger State. The aim of the study is to use remote sensing to improve rice farming activities in Kutigi, Niger State. It is very important to identify such methods to improve Agricultural production because experts are always interested in new researches and findings to better the standard of living in any environment. In view of this, Remotely-sensed data could be used or employed to elevate most of these agricultural problems in Kutigi through the following objectives: Using Landsat imagery to assess the present landuse ...


Variations In Climatic Parameters And Food Crop Yields: Implications On Food Security In Benue State, Nigeria., Emmanuel Adamgbe, Fanan Ujoh Oct 2012

Variations In Climatic Parameters And Food Crop Yields: Implications On Food Security In Benue State, Nigeria., Emmanuel Adamgbe, Fanan Ujoh

Confluence Journal Environmental Studies (CJES), Kogi State University, Nigeria

Agricultural production in Nigeria like in other developing countries is highly vulnerable to variations in climatic parameters which may have inverse or direct effect on the performance of food crops. This paper examines the patterns and trends of the variations in the climatic parameters and the implications of such variations on efficient yield rates of some food crops in Benue State using data on climatic variables (rainfall, temperature, sunshine) and the yield of some crops per hectare for 25 years (1986-2010). Data on the climatic variables were collected from the Nigerian Meteorological Agency, AirForce Base, Makurdi while the data on ...


Dynamics Of Land Use/Land Cover Changes And Its Implication On Food Security In Anyigba, North Central, Nigeria, Tokula E. Arome, Sunday P. Ejaro (Phd) May 2012

Dynamics Of Land Use/Land Cover Changes And Its Implication On Food Security In Anyigba, North Central, Nigeria, Tokula E. Arome, Sunday P. Ejaro (Phd)

Confluence Journal Environmental Studies (CJES), Kogi State University, Nigeria

This study assessed land use/land cover changes and its effect on Agricultural land in Anyigba. The objectives were to identify and delineate different land use / land cover categories, assess the rate of change that occurred and examine the impact of land use/land cover change on food security using satellite remote sensing data collected at three different years (1987 Land sat TM, 2001 Land Sat TM and 2011 Land Sat ETM). The study utilized GIS software such as Idrisi Andes academic and ArcGIS 9.3. The study area covers approximately 31.8km2, and four major land use/cover classes ...


Efficacy Of A Poly-L-Glutamic Acid-Gemcitabine Conjugate In Tumor-Bearing Mice, Kiew Lik Voon, Cheong Soon Keng, Ernidila Ramli, Khalifah Sidik, Tuck Meng Lim, Chung Lip Yong May 2012

Efficacy Of A Poly-L-Glutamic Acid-Gemcitabine Conjugate In Tumor-Bearing Mice, Kiew Lik Voon, Cheong Soon Keng, Ernidila Ramli, Khalifah Sidik, Tuck Meng Lim, Chung Lip Yong

Kiew Lik Voon

Strategy, Management and Health Policy Enabling Technology, Genomics, Proteomics Preclinical Research Preclinical Development Toxicology, Formulation Drug Delivery, Pharmacokinetics Clinical Development Phases I-III Regulatory, Quality, Manufacturing Postmarketing Phase IV This study assessed the in vivo antitumor efficacy of a polypeptide-based poly-L-glutamic acid-gemcitabine conjugate (PG-G). PG-G was synthesized by conjugating gemcitabine to poly-L-glutamic acid by a carbodiimide reaction. PG-G was evaluated for its in vivo antitumor efficacy and toxicity using 4T1 murine breast tumor-bearing mice. The antitumor effects of PG-G were superior to those of unconjugated gemcitabine in both single and four-consecutive dosing studies. Tumor regression was observed within 1 day after ...


Socio-Economic Effects Of Demolishing Squatter Settlements And Illegal Structures In Abuja Metropolis, Federal Capital Territory, Nigeria, Ishaku Iy Mallo Phd, Victor G. Obasanya Jan 2012

Socio-Economic Effects Of Demolishing Squatter Settlements And Illegal Structures In Abuja Metropolis, Federal Capital Territory, Nigeria, Ishaku Iy Mallo Phd, Victor G. Obasanya

Confluence Journal Environmental Studies (CJES), Kogi State University, Nigeria

Abuja the Federal Capital Territory and study area is located between latitudes 8o25’ and 9o25’ North of the Equator and longitudes 6o45’ and 7o45’ East of the Greenwich Meridian. The study was carried out in Abuja Phase 1, and it is aimed at highlighting various socioeconomic effects of demolition of illegal structures and informal or squatter settlements on the people within the study area. Data was collected through reconnaissance survey, personal interviews with respondents, and a well laid out questionnaire. The results indicate that the demolition exercise embarked upon by the authorities in the Federal Capital Territory was a response ...


Rainfall Variability And Crop Zones Classification For The Federal Capital Territory, Nigeria, Shaibu M. Hassan Phd Jan 2012

Rainfall Variability And Crop Zones Classification For The Federal Capital Territory, Nigeria, Shaibu M. Hassan Phd

Confluence Journal Environmental Studies (CJES), Kogi State University, Nigeria

This study aims at analyzing agro-climatological parameters and establishing a link between some selected agro-climatological indices and sustainability of agricultural production in the Federal Capital Territory (FCT). Two sets of data, climatic and crop yield data were collected and subjected to various agro-climatological analyses. Agro-climatological analyses include the derivation of Onset, Cessation and Length of Rainy Season (LRS), Seasonality Index, Drought Index and Precipitation Periodicity Index. The statistical analyses include monthly and annual means, deviation from the mean, trend line. The result of moisture index in line with crops optimum moisture requirement was used to classify the Territory into agro-climatic ...


Eurycomanone Suppresses Expression Of Lung Cancer Cell Tumor Markers, Prohibitin, Annexin 1 And Endoplasmic Reticulum Protein 28, Wong Pooi Fong Jan 2012

Eurycomanone Suppresses Expression Of Lung Cancer Cell Tumor Markers, Prohibitin, Annexin 1 And Endoplasmic Reticulum Protein 28, Wong Pooi Fong

Wong Pooi Fong

Bioactive compounds from the medicinal plant, Eurycoma longifolia Jack have been shown to promote anti-proliferative effects on various cancer cell lines. Here we examined the effects of purified eurycomanone, a quassinoid found in Eurycoma longifolia Jack extract, on the expression of selected genes of the A549 lung cancer cells. Eurycomanone inhibited A549 lung cancer cell proliferation in a dose-dependent manner at concentrations ranging from 5 to 20 mu g/ml. The concentration that inhibited 50% of cell growth (GI(50)) was 5.1 mu g/ml. The anti-proliferative effects were not fully reversible following the removal of eurycomanone, in which ...


Erectogenic Effects Of Clerodendron Capitatum: Involvement Of Phosphodiesterase Type-5 Inhibition, Dr Syam Mohan Jan 2012

Erectogenic Effects Of Clerodendron Capitatum: Involvement Of Phosphodiesterase Type-5 Inhibition, Dr Syam Mohan

Syam Mohan

No abstract provided.


Clausena Excavata Burm. F. (Rutaceae): A Review Of Its Traditional Uses, Pharmacological And Phytochemical Properties., Dr Syam Mohan Jan 2012

Clausena Excavata Burm. F. (Rutaceae): A Review Of Its Traditional Uses, Pharmacological And Phytochemical Properties., Dr Syam Mohan

Syam Mohan

The present review describes the morphological, traditional, phytochemical and pharmacological aspects of Clausena excavata (Burm. f., Rutaceae). The plant grows wild in the tropical and subtropical parts of Asia and represents one of the richest sources of medicinal natural products. It is intensively used currently in traditional medicine for treatment of different illnesses. One part or a mixture of two or more parts of the plant in the form of powder or liquid doze is usually given to the patient. Phytochemically, many pure compounds from several secondary metabolite groups of C. excavata have been isolated from different parts of the ...


Chloroform Fraction Of Centratherum Anthelminticum (L.) Seed Inhibits Tumor Necrosis Factor Alpha And Exhibits Pleotropic Bioactivities: Inhibitory Role In Human Tumor Cells, Dr Syam Mohan Jan 2012

Chloroform Fraction Of Centratherum Anthelminticum (L.) Seed Inhibits Tumor Necrosis Factor Alpha And Exhibits Pleotropic Bioactivities: Inhibitory Role In Human Tumor Cells, Dr Syam Mohan

Syam Mohan

We investigated the antioxidant potential, cytotoxic effect, and TNF-α inhibition activity with NF-κB activation response in a chloroformfraction of Centratherum anthelminticum seeds (CACF). The antioxidant property of CACF was evaluated with DPPH, ORAC, and FRAP assays, which demonstrated significant antioxidant activity. The cytotoxicity of CACF was tested using theMTT assay; CACF effective inhibitory concentrations (IC50) for A549, PC-3, MCF-7, and WRL-68 cells were 31.42 ± 5.4, 22.61 ± 1.7, 8.1±0.9, and 54.93±8.3 μg/mL, respectively. CACF effectively and dose-dependently inhibited TNF-α release, in vitro and in vivo. CACF inhibited TNF-Π...


In Vitro Anti-Inflammatory, Cytotoxic And Antioxidant Activities Of Boesenbergin A, A Chalcone Isolated From Boesenbergia Rotunda (L.) (Fingerroot), Dr Syam Mohan Jan 2012

In Vitro Anti-Inflammatory, Cytotoxic And Antioxidant Activities Of Boesenbergin A, A Chalcone Isolated From Boesenbergia Rotunda (L.) (Fingerroot), Dr Syam Mohan

Syam Mohan

The current in vitro study was designed to investigate the anti-inflammatory, cytotoxic and antioxidant activities of boesenbergin A (BA), a chalcone derivative of known structure isolated from Boesenbergia rotunda. Human hepatocellular carcinoma (HepG2), colon adenocarcinoma (HT-29), non-small cell lung cancer (A549), prostate adenocarcinoma (PC3), and normal hepatic cells (WRL-68) were used to evaluate the cytotoxicity of BA using the MTT assay. The antioxidant activity of BA was assessed by the ORAC assay and compared to quercetin as a standard reference antioxidant. ORAC results are reported as the equivalent concentration of Trolox that produces the same level of antioxidant activity as ...


Synthesis Of Chalcones With Anticancer Activities., Dr Syam Mohan Jan 2012

Synthesis Of Chalcones With Anticancer Activities., Dr Syam Mohan

Syam Mohan

Several chalcones were synthesized and their in vitro cytotoxicity against various human cell lines, including human breast adenocarcinoma cell line MCF-7, human lung adenocarcinoma cell line A549, human prostate cancer cell line PC3, human adenocarcinoma cell line HT-29 (colorectal cancer) and human normal liver cell line WRL-68 was evaluated. Most of the compounds being active cytotoxic agents, four of them with minimal IC50 values were chosen and studied in detail with MCF-7 cells. The compounds 1, 5, 23, and 25 were capable in eliciting apoptosis in MCF-7 cells as shown by multiparameter cytotoxicity assay and caspase-3/7, -8, and -9 ...


Cucurbitacin L 2-O- Glucoside Demonstrates Apoptogenesis In Colon Adenocarcinoma Cells (Ht-29): Involvement Of Reactive Oxygen And Nitrogen Species Regulation, Dr Syam Mohan Jan 2012

Cucurbitacin L 2-O- Glucoside Demonstrates Apoptogenesis In Colon Adenocarcinoma Cells (Ht-29): Involvement Of Reactive Oxygen And Nitrogen Species Regulation, Dr Syam Mohan

Syam Mohan

Emerging evidence suggests that reactive oxygen (ROS) and nitrogen (RNS) species can contribute to diverse signalling pathways of inflammatory and tumour cells. Cucurbitacins are a group of highly oxygenated triterpenes. Many plants used in folk medicine to treat cancer have been found to contain cucurbitacins displaying potentially important anti-inflammatory actions. The current study was designed to investigate the anti-ROS and -RNS effects of cucurbitacin L 2-O-β-glucoside (CLG) and the role of these signaling factors in the apoptogenic effects of CLG on human colon cancer cells (HT-29). This natural cucurbitacin was isolated purely from Citrullus lanatus var. citroides (Cucurbitaceae). The results ...


Dentatin Induces Apoptosis In Prostate Cancer Cells Via Bcl-2, Bcl-Xl, Survivin Downregulation, Caspase-9, -3/7 Activation And Nf-Kb Inhibition., Dr Syam Mohan Jan 2012

Dentatin Induces Apoptosis In Prostate Cancer Cells Via Bcl-2, Bcl-Xl, Survivin Downregulation, Caspase-9, -3/7 Activation And Nf-Kb Inhibition., Dr Syam Mohan

Syam Mohan

This study was set to investigate antiproliferative potential of dentatin (a natural coumarin isolated from Clausena excavata Burm. F) against prostate cancer and to delineate the underlying mechanism of action. Treatment with dentatin dose-dependently inhibited cell growth of PC-3 and LNCaP prostate cancer cell lines, whereas it showed less cytotoxic effects on normal prostate epithelial cell line (RWPE-1). The inhibitory effect of dentatin on prostate cancer cell growth was due to induction of apoptosis as evidenced by Annexin V staining and cell shrinkage. We found that dentatin-mediated accumulation of reactive oxygen species (ROS) and downregulated expression levels of antiapoptotic molecules ...


Antiviral Activity Of Four Types Of Bioflavonoid Against Dengue Virus Type-2, Wong Pooi Fong Dec 2011

Antiviral Activity Of Four Types Of Bioflavonoid Against Dengue Virus Type-2, Wong Pooi Fong

Wong Pooi Fong

Background: Dengue is a major mosquito-borne disease currently with no effective antiviral or vaccine available. Effort to find antivirals for it has focused on bioflavonoids, a plant-derived polyphenolic compounds with many potential health benefits. In the present study, antiviral activity of four types of bioflavonoid against dengue virus type -2 (DENV-2) in Vero cell was evaluated. Anti-dengue activity of these compounds was determined at different stages of DENV-2 infection and replication cycle. DENV replication was measured by Foci Forming Unit Reduction Assay (FFURA) and quantitative RT-PCR. Selectivity Index value (SI) was determined as the ratio of cytotoxic concentration 50 (CC50 ...


Optimal Protein Extraction Methods From Diverse Sample Types For Protein Profiling By Using Two-Dimensional Electrophoresis (2de), Kiew Lik Voon Dec 2011

Optimal Protein Extraction Methods From Diverse Sample Types For Protein Profiling By Using Two-Dimensional Electrophoresis (2de), Kiew Lik Voon

Kiew Lik Voon

There is a great diversity of protein samples types and origins, therefore the optimal procedure for each sample type must be determined empirically. In order to obtain a reproducible and complete sample presentation which view as many proteins as possible on the desired 2DE gel, it is critical to perform additional sample preparation steps to improve the quality of the final results, yet without selectively losing the proteins. To address this, we developed a general method that is suitable for diverse sample types based on phenol-chloroform extraction method (represented by TRI reagent). This method was found to yield good results ...


In Vitro Antiviral Activity Of Fisetin, Rutin And Naringenin Against Dengue Virus Type-2, Wong Pooi Fong Oct 2011

In Vitro Antiviral Activity Of Fisetin, Rutin And Naringenin Against Dengue Virus Type-2, Wong Pooi Fong

Wong Pooi Fong

In vitro antiviral activities of three flavonoids; fisetin, naringenin and rutin against DENV-2 (NGC strain) were evaluated. Inhibitory effects of each compound at the different stages of DENV-2 infection were examined using foci forming unit reduction assay (FFURA) and quantitative real-time polymerase chain amplification (qRT-PCR). Fisetin, rutin and naringenin showed cytotoxic effects against Vero cells with 50% cytotoxicity (CC(50)) values of 247, > 1000, and 87 mu g/mL, respectively. Fisetin when added to Vero cells after virus adsorption inhibited DENV replication with a half maximal inhibition concentration (IC(50)) value of 55 mu g/mL and selectivity index (SI ...


Assessment Of Organic And Inorganic Phosphorus In Soils Derived From Cretaceous Sediments And Basement Complex Soils Of Guinea Savannah Of Kogi State, North Central Nigeria, Sunday I. Amhakhian, H H. Isitekhale, Charles I. Oyewole Aug 2011

Assessment Of Organic And Inorganic Phosphorus In Soils Derived From Cretaceous Sediments And Basement Complex Soils Of Guinea Savannah Of Kogi State, North Central Nigeria, Sunday I. Amhakhian, H H. Isitekhale, Charles I. Oyewole

Confluence Journal Environmental Studies (CJES), Kogi State University, Nigeria

A pot experiment was carried out using 20 surface soils (0-15cm depth) in 2008 to assess soil organic phosphorus and some fraction of inorganic phosphorus in other to know their availability in the soils of the studied area and also work have not been done in this areas in respect to organic and in-organic phosphorus. The experiment was conducted using 20 soils 10 from each geological formation (Cretaceous sediments and Basement complex soils), respectively. The mean organic phosphorus of 63.51 mgkg 1 soil was obtained for Cretaceous sediment soils and 158.54 mgkg 1 soil for the basement complex ...