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California Polytechnic State University, San Luis Obispo

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Exercise

Articles 1 - 6 of 6

Full-Text Articles in Life Sciences

Exhaustive Exercise Training Enhances Aerobic Capacity In American Alligator (Alligator Mississippiensis), John Eme, Tomasz Owerkowicz, June Gwalthney, Jason M. Blank, Bryan C. Rourke, James W. Hicks Nov 2009

Exhaustive Exercise Training Enhances Aerobic Capacity In American Alligator (Alligator Mississippiensis), John Eme, Tomasz Owerkowicz, June Gwalthney, Jason M. Blank, Bryan C. Rourke, James W. Hicks

Biological Sciences

The oxygen transport system in mammals is extensively remodelled in response to repeated bouts of activity, but many reptiles appear to be ‘metabolically inflexible’ in response to exercise training. A recent report showed that estuarine crocodiles (Crocodylus porosus) increase their maximum metabolic rate in response to exhaustive treadmill training, and in the present study, we confirm this response in another crocodilian, American alligator (Alligator mississippiensis). We further specify the nature of the crocodilian training response by analysing effects of training on aerobic [citrate synthase (CS)] and anaerobic [lactate dehydrogenase (LDH)] enzyme activities in selected skeletal muscles, ventricular and skeletal muscle ...


Impact Of Metformin On Peak Aerobic Capacity, Barry Braun, Pamela Eze, Brooke R. Stephens, Todd A. Hagobian, Carrie G. Sharoff, Stuart R. Chipkin, Benjamin Goldstein Feb 2008

Impact Of Metformin On Peak Aerobic Capacity, Barry Braun, Pamela Eze, Brooke R. Stephens, Todd A. Hagobian, Carrie G. Sharoff, Stuart R. Chipkin, Benjamin Goldstein

Kinesiology

Individually, exercise and the drug metformin have been shown to prevent or delay type 2 diabetes. Metformin mildly inhibits complex I of the electron transport system and may impact aerobic capacity in people exercising while taking metformin. The purpose of the study was to evaluate the effects of metformin on maximal aerobic capacity in healthy individuals without mitochondrial dysfunction. Seventeen healthy, normal-weight men (n=11) and women (n=6) participated in a double-blind, placebo-controlled, cross-over design. Peak aerobic capacity was measured twice using a continuous, incrementally graded protocol; once after 7-9 d of metformin (final dose=2000 mg/d) and ...


The Long And Winding Road: Influences Of Intracellular Metabolite Diffusion On Cellular Organization And Metabolism In Skeletal Muscle, Stephen T. Kinsey, Kristin M. Hardy, Bruce R. Locke Jan 2007

The Long And Winding Road: Influences Of Intracellular Metabolite Diffusion On Cellular Organization And Metabolism In Skeletal Muscle, Stephen T. Kinsey, Kristin M. Hardy, Bruce R. Locke

Biological Sciences

A fundamental principle of physiology is that cells are small in order to minimize diffusion distances for O2 and intracellular metabolites. In skeletal muscle, it has long been recognized that aerobic fibers that are used for steady state locomotion tend to be smaller than anaerobic fibers that are used for burst movements. This tendency reflects the interaction between diffusion distances and aerobic ATP turnover rates, since maximal intracellular diffusion distances are ultimately limited by fiber size. The effect of diffusion distance on O2 flux in muscle has been the subject of quantitative analyses for a century, but the ...


A Reaction–Diffusion Analysis Of Energetics In Large Muscle Fibers Secondarily Evolved For Aerobic Locomotor Function, Kristin M. Hardy, Bruce R. Locke, Marilia Da Silva, Stephen T. Kinsey Jan 2006

A Reaction–Diffusion Analysis Of Energetics In Large Muscle Fibers Secondarily Evolved For Aerobic Locomotor Function, Kristin M. Hardy, Bruce R. Locke, Marilia Da Silva, Stephen T. Kinsey

Biological Sciences

The muscles that power swimming in the blue crab, Callinectes sapidus, grow hypertrophically, such that in juvenile crabs the cell diameters are


Does Intracellular Metabolite Diffusion Limit Post-Contractile Recovery In Burst Locomotor Muscle?, Stephen T. Kinsey, Pragyansri Pathi, Kristin M. Hardy, Amanda Jordan, Bruce R. Locke Jan 2005

Does Intracellular Metabolite Diffusion Limit Post-Contractile Recovery In Burst Locomotor Muscle?, Stephen T. Kinsey, Pragyansri Pathi, Kristin M. Hardy, Amanda Jordan, Bruce R. Locke

Biological Sciences

Post-metamorphic growth in the blue crab entails an increase in body mass that spans several orders of magnitude. The muscles that power burst swimming in these animals grow hypertrophically, such that small crabs have fiber diameters that are typical of most cells (600μm). Thus, as the animals grow, their muscle fibers cross and greatly exceed the surface area to volume ratio (SA:V) and intracellular diffusion distance threshold that is adhered to by most cells. Large fiber size should not impact burst contractile function, but post-contractile recovery may be limited by low SA:V and excessive intracellular diffusion distances. A ...


The Role Of Adherence In Mediating The Relationship Between Depression And Health Outcomes, Rena R. Wing, Suzanne Phelan, Deborah Tate Oct 2002

The Role Of Adherence In Mediating The Relationship Between Depression And Health Outcomes, Rena R. Wing, Suzanne Phelan, Deborah Tate

Kinesiology

Depression has been linked to poor health outcome in a number of studies; however, the mechanism underlying this relationship has received little attention. This paper explores the possibility that adherence mediates the relationship between depression and outcome. Principal findings regarding the relationship between depression, adherence, and outcome are reviewed. The data suggest that depression is related, at least moderately, to poorer adherence to a variety of treatment components. The relationship between adherence and outcome is more difficult to establish. In addition, current data, albeit limited, do not support the hypothesis that adherence mediates the relationship between depression and outcome. An ...