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California Polytechnic State University, San Luis Obispo

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2011

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Articles 1 - 30 of 65

Full-Text Articles in Life Sciences

How To Control Texture In Cultured Dairy, Phillip S. Tong Dec 2011

How To Control Texture In Cultured Dairy, Phillip S. Tong

Dairy Science

No abstract provided.


Maternal Smoking During Pregnancy And Risk Factors For Cardiovascular Disease In Adulthood, Bernardo Lessa Horta, Denise P. Gigante, Aydin Nazmi, Vera Maria F. Silveira, Isabel Oliveira, Cesar G. Victora Dec 2011

Maternal Smoking During Pregnancy And Risk Factors For Cardiovascular Disease In Adulthood, Bernardo Lessa Horta, Denise P. Gigante, Aydin Nazmi, Vera Maria F. Silveira, Isabel Oliveira, Cesar G. Victora

Food Science and Nutrition

Objective: This study was aimed at assessing the effect of maternal smoking during pregnancy on metabolic cardiovascular risk factors in early adulthood in a Brazilian birth cohort, after controlling for possible confounding variables and health behaviors in early adulthood.

Methods: In 1982, the maternity hospitals in Pelotas, southern Brazil, were visited and all births were identified. Those livebirths whose family lived in the urban area of the city were studied prospectively. In 2004–2005, we attempted to follow the whole cohort, the subjects were interviewed, examined and blood sample was collected. The following outcomes were studied: blood pressure; HDL cholesterol ...


Utilizing Fishermen Knowledge And Expertise: Keys To Success For Collaborative Fisheries Research, Noëlle Yochum, Richard M. Starr, Dean Wendt Dec 2011

Utilizing Fishermen Knowledge And Expertise: Keys To Success For Collaborative Fisheries Research, Noëlle Yochum, Richard M. Starr, Dean Wendt

Biological Sciences

Collaborative fisheries research provides a mechanism for integrating the unique knowledge, experience, and skills of fishermen and scientists. It is a joint intellectual endeavor that begins with the inception of a project and continues until its final stages, with each group having mutual investment in—and ownership of— the project. Collaborative fisheries research promotes communication and trust among fishermen, scientists, and managers and can provide much-needed scientifically valid data for fisheries management. It can enhance federal and state management data collection programs, which span broad sections of coastline, by increasing the ability to detect changes in local metapopulations that may ...


Perceived Built Environment And Physical Activity In U.S. Women By Sprawl And Region, Philip J. Troped, Kosuke Tamura, Heather A. Whitcomb, Francine Laden Nov 2011

Perceived Built Environment And Physical Activity In U.S. Women By Sprawl And Region, Philip J. Troped, Kosuke Tamura, Heather A. Whitcomb, Francine Laden

Kinesiology

Background

A number of studies have demonstrated relationships between the perceived built environment and physical activity among adults. However, little is known about whether these associations differ by U.S. region and level of urban sprawl.

Purpose

To examine associations between the perceived built environment and physical activity in U.S. women by region and urban sprawl.

Methods

Nurses' Health Study II participants (N=68,968) completed four perceived neighborhood environment survey items in 2005. Logistic regression was used to estimate associations with meeting physical activity recommendations, adjusting for demographic and weight-status variables, and stratifying by region and sprawl. Data ...


Eating Frequency Is Higher In Weight Loss Maintainers And Normal-Weight Individuals Than In Overweight Individuals, Jessica L. Bachman, Suzanne Phelan, Rena R. Wing, Hollie A. Raynor Nov 2011

Eating Frequency Is Higher In Weight Loss Maintainers And Normal-Weight Individuals Than In Overweight Individuals, Jessica L. Bachman, Suzanne Phelan, Rena R. Wing, Hollie A. Raynor

Kinesiology

Eating frequency has been negatively related to body mass index (BMI). The relationship between eating frequency and weight loss maintenance is unknown. This secondary analysis examined eating frequency (self-reported meals and snacks consumed per day) in weight loss maintainers (WLM) who had reduced from overweight/obese to normal weight, normal weight (NW) individuals, and overweight (OW) individuals. Data collected July 2006 to March 2007 in Providence, RI, included three 24-hour dietary recalls (2 weekdays, 1 weekend day) analyzed using Nutrient Data System for Research software from 257 adults (WLM n=96, 83.3% women aged 50.0±11.8 years ...


Climate Change, Body Size, And Phenotype Dependent Dispersal, Shannon J. Mccauley, Karen E. Mabry Nov 2011

Climate Change, Body Size, And Phenotype Dependent Dispersal, Shannon J. Mccauley, Karen E. Mabry

Biological Sciences

No abstract provided.


Parasite Infection And Sand Coarseness Increase Sand Crab (Emerita Analoga) Burrowing Time, Gita R. Kolluru, Zachary S. Green, Larisa K. Vredevoe, Matthew R. Kuzma, Sera N. Ramadan, Marc R. Zosky Nov 2011

Parasite Infection And Sand Coarseness Increase Sand Crab (Emerita Analoga) Burrowing Time, Gita R. Kolluru, Zachary S. Green, Larisa K. Vredevoe, Matthew R. Kuzma, Sera N. Ramadan, Marc R. Zosky

Biological Sciences

Parasites with indirect life cycles require trophic transmission from intermediate hosts to definitive (vertebrate) hosts. Transmission may be facilitated if parasite infection alters the behavior of intermediate hosts such that they are more vulnerable to predation. Vulnerability to predation may also be influenced by abiotic factors; however, rarely are the effects of parasites and abiotic factors examined simultaneously. The swash zone of sandy beaches is a particularly harsh environment. Sand crabs (Emerita analoga) burrow rapidly in the swash zone to avoid predators and dislodgment. We examined prevalence and abundance of the acanthocephalan parasite Profilicollis altmani in sand crabs, and investigated ...


Trails And Physical Activity: A Review, Heather A. Starnes, Philip J. Troped, David B. Klenosky, Angela M. Doehring Nov 2011

Trails And Physical Activity: A Review, Heather A. Starnes, Philip J. Troped, David B. Klenosky, Angela M. Doehring

Kinesiology

To provide a synthesis of research on trails and physical activity from the public health, leisure sciences, urban planning, and transportation literatures. Methods: A search of databases was conducted to identify studies published between 1980 and 2008. Results: 52 studies were identified. The majority were cross-sectional (92*%) and published after 1999 (11%). The evidence for the effects of trails on physical activity was mixed among 3 intervention and 5 correlational studies. Correlates of trail use were examined in 13 studies. Several demographic (eg, race, education, income) and environmental factors (eg, land-use mix and distance to trail) were related to trail ...


Response Of Evergreen Perennial Tree Crops To Gibberellic Acid Is Crop Load-Dependent: Ii. Ga3 Increases Yield And Fruit Size Of ‘Hass’ Avocado Only In The On-Crop Year Of An Alternate Bearing Orchard, Lauren C. Garner, Grant Klein, Yusheng Zheng, Toan Khuong, Carol J. Lovatt Oct 2011

Response Of Evergreen Perennial Tree Crops To Gibberellic Acid Is Crop Load-Dependent: Ii. Ga3 Increases Yield And Fruit Size Of ‘Hass’ Avocado Only In The On-Crop Year Of An Alternate Bearing Orchard, Lauren C. Garner, Grant Klein, Yusheng Zheng, Toan Khuong, Carol J. Lovatt

Horticulture and Crop Science

Despite problems of low fruit set, small fruit size and alternate bearing, the Hass cultivar dominates commercial avocado production worldwide. To increase yield and fruit size, gibberellic acid (GA3) (25 mg L−1) was applied at different stages of ‘Hass’ avocado tree phenology: (i) mid–late April (flower abscission), end of June–beginning of July (fruit abscission and beginning of the exponential phase of fruit growth), and mid-January (beginning of pre-harvest fruit drop); (ii) end of June–beginning of July; and (iii) mid-September (near the end of the major fruit abscission period; period of exponential fruit growth). In both ...


Capstone Experiences: Effects Of Adapted Physical Activity Design Projects On Attitudes And Learning, David W. Hey, Bridie Jean Mccarey, Lynne A. Slivovsky, J. Kevin Taylor, Brian Self, James Widmann Oct 2011

Capstone Experiences: Effects Of Adapted Physical Activity Design Projects On Attitudes And Learning, David W. Hey, Bridie Jean Mccarey, Lynne A. Slivovsky, J. Kevin Taylor, Brian Self, James Widmann

Kinesiology

Eight innovative senior level capstone engineering projects were completed at California Polytechnic State University (2008-present) involving (n=28) students (23 male/5 female). All projects involved the design of equipment to facilitate physical activity for people with disabilities. The effects on: i) learning design, ii) attitude towards people with disabilities, and iii) motivation to complete team design projects were analyzed through eight one-hour focus groups. This paper presents focus group findings using a constructivist approach and grounded theory to explore the overall student “learn by doing” experience. Results: (1) Approximately 19 (70%) of the students claimed the adapted physical activity ...


Cultured Cream Products Must Live Up To The Name, Phillip S. Tong Sep 2011

Cultured Cream Products Must Live Up To The Name, Phillip S. Tong

Dairy Science

No abstract provided.


Effect Of Tannin Additions Postfermentation With Gelatin Remediation In Paso Robles Cabernet Sauvignon, Briana Heywood, Geraldine S.P. Ritchie Sep 2011

Effect Of Tannin Additions Postfermentation With Gelatin Remediation In Paso Robles Cabernet Sauvignon, Briana Heywood, Geraldine S.P. Ritchie

Food Science and Nutrition

The resultant color of a Cabernet Sauvignon wine connotes overall quality. Therefore, it is in the best interests of a winery to produce a well-balanced wine, containing the deepest color possible, using the least amount of additives. This experiment studied the effects of adding ColorPro, VRSupra, and Gelatin Extra No.1 to Cabernet Sauvignon fruit from Paso Robles to determine if anthocyanin and tannin levels changed with respect to the aforementioned supplements. To increase color and tannin extraction, ColorPro was added to the grape must prior to fermentation. A tannin powder, VRSupra, was added later in the winemaking process to ...


The Proteomic Response Of Sea Squirts (Genus Ciona) To Acute Heat Stress: A Global Perspective On The Thermal Stability Of Proteins, Loredana Serafini, Jay B. Hann, Dietmar Kültz, Lars Tomanek Sep 2011

The Proteomic Response Of Sea Squirts (Genus Ciona) To Acute Heat Stress: A Global Perspective On The Thermal Stability Of Proteins, Loredana Serafini, Jay B. Hann, Dietmar Kültz, Lars Tomanek

Biological Sciences

Congeners belonging to the genus Ciona have disparate distributions limited by temperature. Ciona intestinalis is more widespread with a cosmopolitan distribution ranging from tropical to sub-arctic zones, while Ciona savignyi is limited to temperate-latitudes of the northern Pacific Ocean. To compare the heat stress response between congeners, we quantified changes in protein expression using proteomics. Animals were exposed to 22 °C, 25 °C, and 28 °C for 6 h, then recovered at a control temperature (13 °C) for 16 h (high heat stress experiment). In a second experiment we exposed animals to lower levels of heat stress at 18 °C ...


Educational Curriculum Standards & Standardized Educational Tests: Comparing Apples & Oranges?, William D. Stansfield Sep 2011

Educational Curriculum Standards & Standardized Educational Tests: Comparing Apples & Oranges?, William D. Stansfield

Biological Sciences

Mandated biology curriculum standards and standardized tests may vary widely from one state to another, making academic-performance comparisons among the states problematic. This report outlines the effects of the “No Child Left Behind” law and uses California as a test case against which teachers in other states may make comparisons of their own biology curriculum standards and tests. Several sources are cited that offer sample multiple-choice questions that have appeared on previous California standardized tests for sciences/life sciences/biology. These examples, and critique thereof, may help teachers better prepare their own tests to improve student performance in meeting the ...


Season And Sex Of Host Affect Intensities Of Ectoparasites In Western Fence Lizards (Sceloporus Occidentalis) On The Central Coast Of California, Anthony S. Lumbad, Larisa K. Vredevoe, Emily N. Taylor Sep 2011

Season And Sex Of Host Affect Intensities Of Ectoparasites In Western Fence Lizards (Sceloporus Occidentalis) On The Central Coast Of California, Anthony S. Lumbad, Larisa K. Vredevoe, Emily N. Taylor

Biological Sciences

Seasonal variability in intensities of ectoparasites of western fence lizards (Sceloporus occidentalis) was quantified in spring, summer, and autumn 2008. Lizards were suspended over pans of water in the laboratory to enumerate replete western black-legged ticks (Ixodes pacificus) and mites. Intensity of ectoparasites was greatest in spring. On average, mites comprised the greatest proportion of ectoparasites, followed by larval and nymphal ticks, respectively. Mites were on lizards year-round. Overall intensity of ticks was greatest in spring, but low during summer and autumn. Males were more heavily parasitized by ticks than females in spring, whereas females had greater intensities of mites ...


Evaluation Of Fungicides And Fungicide Programs For Control Of Dollar Spot Creeping Bentgrass In Kansas, 2010, M Kennelly, C Thompson, Z Raudenbush Aug 2011

Evaluation Of Fungicides And Fungicide Programs For Control Of Dollar Spot Creeping Bentgrass In Kansas, 2010, M Kennelly, C Thompson, Z Raudenbush

Horticulture and Crop Science

No abstract provided.


Preventative Fungicide Application For Control Of Dollar Spot On Creeping Bentgrass In Kansas, 2010, M Kennelly, Z Raudenbush, Cole Thompson Aug 2011

Preventative Fungicide Application For Control Of Dollar Spot On Creeping Bentgrass In Kansas, 2010, M Kennelly, Z Raudenbush, Cole Thompson

Horticulture and Crop Science

No abstract provided.


Informing Carbon In Arctic Reservoirs Vulnerability Experiment Flight Schedule Based Upon Soil And Vegetation Freeze And Thaw Event Variation Along The Alaska Ecological Transect, Jessica Potter, Kyle Mcdonald, Erika Podest Aug 2011

Informing Carbon In Arctic Reservoirs Vulnerability Experiment Flight Schedule Based Upon Soil And Vegetation Freeze And Thaw Event Variation Along The Alaska Ecological Transect, Jessica Potter, Kyle Mcdonald, Erika Podest

STAR (STEM Teacher and Researcher) Presentations

Established in the 1990s, the Alaska Ecological Transect (ALECTRA) is composed of a series of ground stations extending from the Franklin Bluff on Alaska’s North Slope to the Kenai Peninsula, south of Anchorage. At each station, sets of thermistors are deployed to monitor vegetation tissue temperature, air temperature, and soil profile temperatures. Also sensors are deployed for monitoring sap flow in individual trees. The stations are automated, with data loggers recording this data approximately every two hours. Dates marking the spring thaw and fall freeze transitions in soil and vegetation tissues from sites in Coldfoot, Dietrich Valley, and Bonanza ...


Forward Osmosis Bag: Ground Testing The Prospect Of Using Alternative Water Sources For Drinking Water, Michaela Marie Brant, Ariella Yendler, Mona Hammoudeh, Michael T. Flynn Aug 2011

Forward Osmosis Bag: Ground Testing The Prospect Of Using Alternative Water Sources For Drinking Water, Michaela Marie Brant, Ariella Yendler, Mona Hammoudeh, Michael T. Flynn

STAR (STEM Teacher and Researcher) Presentations

On the STS-135 Space Shuttle mission, to be launched July 8, 2011, a forward osmosis bag (FOB) study will be conducted. At NASA Ames this summer, the ground truth testing is being conducted for results comparisons. The FOB technology is derived from a commercial product, the X-Pack water filter. Forward osmosis operates by utilizing an established concentration gradient across a semi-permeable membrane to move water molecules from one side of the membrane to the other. This concept is exploited to harvest drinking water from grey water sources such as urine, sea water, or vehicle water. In this experiment, potassium chloride ...


Growth And Hydrogen Production Of Rubrivivax Gelatinosus Cbs, Shannon A. Swanson, Karen Wawrousek Aug 2011

Growth And Hydrogen Production Of Rubrivivax Gelatinosus Cbs, Shannon A. Swanson, Karen Wawrousek

STAR (STEM Teacher and Researcher) Presentations

Rubrivivax gelatinosus CBS is a purple non-sulfur photosynthetic bacterium that has been found to produce substantial amounts of Hydrogen (H2) which could be used as a clean burning biofuel. CBS has been known to grow on a variety of carbon sources, but it is unknown as to which carbon sources it has the greatest potential to use, and this understanding could be helpful in engineering future strains of the bacteria. Hydrogen production in CBS occurs when carbon monoxide (CO) is present and is presumed to be under the control of the RcoM transcription factor. When CBS wild-type strains were grown ...


Discovery Of An Apoptosis Inducing Ligand For Burkitt Lymphoma, Carolyn Laymon, Kyla Bradylong, Mary Saunders, David Olivos, Kit Lam Aug 2011

Discovery Of An Apoptosis Inducing Ligand For Burkitt Lymphoma, Carolyn Laymon, Kyla Bradylong, Mary Saunders, David Olivos, Kit Lam

STAR (STEM Teacher and Researcher) Presentations

One-bead two-compound (OB2C) combinatorial chemistry libraries enable the discovery of novel synthetic compounds which can be used to evoke specific signaling response in cells. The library configuration is composed of a fixed known cell adhesion ligand and a random chemical library displayed on the surface of Tentagel beads. The cell adhesion ligand binds to specific receptors located on the surface of cells enabling the random immobilized chemical molecules on each bead resin bead to evoke specific cellular responses such as apoptosis or cell death. To validate this concept, a OB2C combinatorial library comprised of an α4β1 integrin targeting ligand, LLP2A ...


Interspecies Comparison Of Αii-Spectrin Abundance Between Chinook Salmon And Steelhead, Brielle D. Kemis, Ann L. Miracle, Katie A. Wagner, Christa M. Woodley Aug 2011

Interspecies Comparison Of Αii-Spectrin Abundance Between Chinook Salmon And Steelhead, Brielle D. Kemis, Ann L. Miracle, Katie A. Wagner, Christa M. Woodley

STAR (STEM Teacher and Researcher) Presentations

Salmonids, such as Chinook salmon (Oncorhynchus tshawytscha) and steelhead (O. mykiss), are a staple economic, recreational, tribal, and environmental resource, yet many populations are unsustainable. This study was part of a broad scale effort to monitor the impact of downstream migration obstacles on juvenile salmonid health and survival, which is an essential step towards increasing Smolt-to-Adult Return ratios (SARs). The objective of this study was to determine if juvenile Chinook salmon and steelhead exhibit differing quantities of alphaII-Spectrin Breakdown Products (SBDPs) over two consecutive spring migration periods, indicative of neurogenesis rate and/or biological response to head injury. AlphaII-Spectrin is ...


Relationship Of Maternal Flow Environment To Offspring Size In Botrylloides Violaceus, Damion J. Delton, Sarah Cohen Aug 2011

Relationship Of Maternal Flow Environment To Offspring Size In Botrylloides Violaceus, Damion J. Delton, Sarah Cohen

STAR (STEM Teacher and Researcher) Presentations

Colonial botryllid tunicates, such as Botrylloides violaceus, brood large, non-feeding offspring with extremely limited larval life spans of minutes to perhaps one day. Despite the importance of this transitory life history stage, there is little information on how environmental factors such as ambient water flow affect larval size among invertebrates. Since adult tunicates feed by filtering particles from the water flowing around the siphons, we reasoned that colonies of B. violaceus in high water flow may produce larger offspring due to greater food availability. We tested to see whether there was a relationship between larval size and water motion in ...


Temperature Thresholds And Degree-Day Model For Marmara Gulosa (Lepidoptera: Gracillariidae), M. J. O'Neal, David H. Headrick, Gregory H. Montez, E.E. Grafton-Cardwell Aug 2011

Temperature Thresholds And Degree-Day Model For Marmara Gulosa (Lepidoptera: Gracillariidae), M. J. O'Neal, David H. Headrick, Gregory H. Montez, E.E. Grafton-Cardwell

Horticulture and Crop Science

The developmental thresholds for Marmara gulosa Guillen & Davis (Lepidoptera: Gracillariidae) were investigated in the laboratory by using 17, 21, 25, 29, and 33°C. The lowest mortality occurred in cohorts exposed to 25 and 29°C. Other temperatures caused >10% mortality primarily in egg and Þrst and second instar sap-feeding larvae. Linear regression analysis approximated the lower developmental threshold at 12.2°C. High mortality and slow developmental rate at 33°C indicate the upper developmental threshold is near this temperature. The degree-day (DD) model indicated that a generation requires an accumulation of 322 DD for development from egg to adult emergence. Average daily temperatures in the San Joaquin Valley could produce up to seven generations of M. gulosa per year. Field studies documented two, Þve, and three overlapping generations of M. gulosa in walnuts (Juglans regia L.; Juglandaceae), pummelos (Citrus maxima (Burm.) Merr.; Rutaceae), and oranges (Citrus sinensis (L.) Osbeck; Rutaceae), for a total of seven observed peelminer generations. Degree-day units between generations averaged 375 DD for larvae infesting walnut twigs; however, availability of green wood probably affected timing of infestations. Degree-day units between larval generations averaged 322 for pummelos and 309 for oranges, conÞrming the laboratory estimation. First infestation of citrus occurred in June in pummelo fruit and August in orange fruit when fruit neared 60 mm in diameter. Fruit size and degree-day units could be used as management ...


Diabetes Prevalence Is Associated With Serum 25-Hydroxyvitamin D And 1,25-Dihydroxyvitamin D In Us Middle-Aged Caucasian Men And Women: A Cross-Sectional Analysis Within The Prostate, Lung, Colorectal And Ovarian Cancer Screening Trial, Kaye E. Brock, Wen-Yi Huang, David R. Fraser, Liang Ke, Marilyn Tseng, Rebecca S. Mason, Rachael Z. Stolzenberg-Solomon, D. Michal Freedman, Jiyoung Ahn, Ulrike Peters, Catherine Mccarty, Bruce W. Hollis, Regina G. Ziegler, Mark P. Purdue, Barry I. Graubard Aug 2011

Diabetes Prevalence Is Associated With Serum 25-Hydroxyvitamin D And 1,25-Dihydroxyvitamin D In Us Middle-Aged Caucasian Men And Women: A Cross-Sectional Analysis Within The Prostate, Lung, Colorectal And Ovarian Cancer Screening Trial, Kaye E. Brock, Wen-Yi Huang, David R. Fraser, Liang Ke, Marilyn Tseng, Rebecca S. Mason, Rachael Z. Stolzenberg-Solomon, D. Michal Freedman, Jiyoung Ahn, Ulrike Peters, Catherine Mccarty, Bruce W. Hollis, Regina G. Ziegler, Mark P. Purdue, Barry I. Graubard

Kinesiology

Hypovitaminosis D may be associated with diabetes, hypertension and CHD. However, because studies examining the associations of all three chronic conditions with circulating 25-hydroxyvitamin D (25(0H)D) and 1,25-dihydroxyvitamin D (1,25(0H)2D) are limited, we examined these associations in the US Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer Screening Trial (n 2465). Caucasian PLCO participants selected as controls in previous nested case-control studies of 25(0H)D and 1,25(0H)2D were included in this analysis. Diabetes, CHD and hypertension prevalence, risk factors for these conditions and intake of vitamin D and Ca ...


Addressing Biased Occurrence Data In Predicting Potential Sierra Nevada Red Fox Habitat For Survey Prioritization, Casey Cleve, John D. Perrine, Barbara Holzman, Ellen Hines Aug 2011

Addressing Biased Occurrence Data In Predicting Potential Sierra Nevada Red Fox Habitat For Survey Prioritization, Casey Cleve, John D. Perrine, Barbara Holzman, Ellen Hines

Biological Sciences

The Sierra Nevada red fox Vulpes vulpes necator is listed as a threatened species under the California Endangered Species Act. It originally occurred throughout California’s Cascade and Sierra Nevada mountain regions. Its current distribution is unknown but should be determined in order to guide management actions. We used occurrence data from the only known population, in the Lassen Peak region of northern California, combined with climatic and remotely sensed variables, to predict the species’ potential distribution throughout its historic range. These model predictions can guide future surveys to locate additional fox populations. Moreover, they allow us to compare the ...


Computational Identification Of Protein Catalytic Sites: Tests, Validation, Dan Kirshner, Jerome Nilmeier, Felice Lightstone Aug 2011

Computational Identification Of Protein Catalytic Sites: Tests, Validation, Dan Kirshner, Jerome Nilmeier, Felice Lightstone

STAR (STEM Teacher and Researcher) Presentations

This project is one element of the analysis “pipeline” to characterize an organism that previously has not been well-studied. Once a protein of unknown structure has been computationally modeled (based on its sequence similarity to proteins with solved structures), then catalytic sites are identified on the model by comparison to a library of known sites. This work tested the identification algorithms with a set of proteins that have known structures and catalytic sites.


Physiologically-Based Pharmacokinetic Modeling For Predicting Drug-Drug Interactions, David M. Ng, Ali Navid Aug 2011

Physiologically-Based Pharmacokinetic Modeling For Predicting Drug-Drug Interactions, David M. Ng, Ali Navid

STAR (STEM Teacher and Researcher) Presentations

Dynamics of interactions between the drugs caffeine and ciprofloxacin are predicted using physiologically-based pharmacokinetic (PBPK) modeling. Pharmacokinetic means the model determines where the drugs are distributed in the body over time. Physiologically-based means the anatomy and physiology of the human body is reflected in the structure and functioning of the model. Multiple drugs can interact to increase or decrease their beneficial and/or undesired effects. This is important because some common substances, such as caffeine in coffee and soft drinks, are actually drugs that affect the body. By implementing the model as a computer program, it is relatively straightforward to ...


Bridging The Marine-Terrestrial Disconnect To Improve Marine Coastal Zone Science And Management, Benjamin I. Ruttenberg, Elise F. Granek Jul 2011

Bridging The Marine-Terrestrial Disconnect To Improve Marine Coastal Zone Science And Management, Benjamin I. Ruttenberg, Elise F. Granek

Biological Sciences

Coastal zone ecosystems sit between larger terrestrial and marine environments and, therefore, are strongly affected by processes occurring in both systems. Marine coastal zone systems provide a range of benefits to humans, and yet many have been significantly degraded as a result of direct and indirect human impacts. Management efforts have been hampered by disconnects both between management and scientific research and across linked marine–terrestrial systems. Management jurisdictions often start or end at the shoreline, and multiple agencies at different levels of government often have overlapping or conflicting management goals or priorities, or suffer from a lack of knowledge ...


Thermal-Initiated Hydroxyethyl Methacrylate Functionalization Of Multiwalled Carbon Nanotubes, Greg Curtzwiler, Philip Costanzo, Ray Fernando, Jeffrey E. Danes, Keith Vorst Jul 2011

Thermal-Initiated Hydroxyethyl Methacrylate Functionalization Of Multiwalled Carbon Nanotubes, Greg Curtzwiler, Philip Costanzo, Ray Fernando, Jeffrey E. Danes, Keith Vorst

Chemistry and Biochemistry

Multiwalled-carbon nanotubes (MWCNTs) were functionalized via thermoinitiated free radical polymerization of 2-hydroxyethyl methacrylate (HEMA) using benzoyl peroxide. Tip sonication was used during the polymerization reaction to separate agglomerated nanotubes. The functionalization was confirmed by control experiments and attenuated total reflectance Fourier transform infrared spectroscopy (ATR-FTIR). Differential scanning calorimetry indicated that the addition of poly(HEMA)-MWCNTs to a two-component polyurethane coating will have little effect on the glass transition temperature of the coating. The poly(HEMA)-functionalized MWCNTs formed large colloidal structures of highly dispersed nanotubes in both the nonsheared and sheared coatings as determined by atomic force microscopy. This ...