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California Polytechnic State University, San Luis Obispo

Series

Kinesiology

Sibutramine

Publication Year

Articles 1 - 2 of 2

Full-Text Articles in Life Sciences

Impact Of Weight Loss On The Metabolic Syndrome, Suzanne Phelan, T. A. Wadden, R. I. Berkowitz, D. B. Sarwer, L. G. Womble, R. K. Cato, R. Rothman Sep 2007

Impact Of Weight Loss On The Metabolic Syndrome, Suzanne Phelan, T. A. Wadden, R. I. Berkowitz, D. B. Sarwer, L. G. Womble, R. K. Cato, R. Rothman

Kinesiology

Objective:
To evaluate the effects of weight loss on the risk of having metabolic syndrome after 1 year of treatment with lifestyle modification alone, pharmacotherapy alone (sibutramine) or the combination of the two.

Design:
Randomized, controlled, 1-year clinical trial.

Patients:
One hundred and eighty women and 44 men, 18–65 years of age, with a body mass index of 30–45 kg/m2, free of uncontrolled hypertension or type 1 or 2 diabetes.

Intervention:
Fifteen milligrams of sibutramine per day alone, lifestyle modification counseling alone, sibutramine plus lifestyle modification counseling or sibutramine plus brief lifestyle modification counseling.

Measurements:
The metabolic ...


Combining Behavioral And Pharmacological Treatments For Obesity, Suzanne Phelan, Thomas A. Wadden Jun 2002

Combining Behavioral And Pharmacological Treatments For Obesity, Suzanne Phelan, Thomas A. Wadden

Kinesiology

Weight-loss medications are currently recommended for use only as an adjunct to diet, exercise, and behavior modification. Little, however, is known about the benefits of combining behavioral and pharmacological therapies or about the mechanisms that would make these combined approaches more effective than either used alone. This article reviews the effects of adding pharmacotherapy (i.e., principally sibutramine and orlistat) to a modest program of lifestyle modification. Studies revealed that the addition of medication typically improved short- and long-term weight loss compared with lifestyle modification alone. The best results, however, were obtained when medications were combined with an intensive, group ...