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Articles 1 - 30 of 2103

Full-Text Articles in Life Sciences

Genetic Basis For Elevated Rheumatic Heart Disease Susceptibility, Joshua J. Cassinat, Justina P. Tavana, Josue D. Gonzalez Murcia, Rachel C. Mcdonald, Ben Bearss, Joshua K. Parker, John S.K. Kauwe Apr 2019

Genetic Basis For Elevated Rheumatic Heart Disease Susceptibility, Joshua J. Cassinat, Justina P. Tavana, Josue D. Gonzalez Murcia, Rachel C. Mcdonald, Ben Bearss, Joshua K. Parker, John S.K. Kauwe

Library/Life Sciences Undergraduate Poster Competition 2019

Rheumatic heart disease is an inflammatory heart disease that affects millions of people around the world. Especially high rates of the disease can be found in Oceania, including the island nation of Samoa. Genetic studies of immune response genes have provided insight into a possible genetic link to increased susceptibility to rheumatic heart disease, including the genes that code for the toll-like receptor (TLR) protein family. One of the functions of TLR proteins is to recognize the presence of bacteria via identification of bacterial flagella.


Finding A Link Between Impetigo And Rheumatic Heart Disease, Lindsey Meservey, Thomas Knapp, Nathan Mella, Tyler Heaton, Tanner Heaton, Jonathon Hill, Paul Savage Apr 2019

Finding A Link Between Impetigo And Rheumatic Heart Disease, Lindsey Meservey, Thomas Knapp, Nathan Mella, Tyler Heaton, Tanner Heaton, Jonathon Hill, Paul Savage

Library/Life Sciences Undergraduate Poster Competition 2019

Rheumatic heart disease is a deadly condition pervasive in tropical third world countries like Samoa. In order to prevent rheumatic heart disease, we seek to understand the origins of rheumatic heart disease. Specifically, we want to understand if streptococcal infections of the skin, commonly called impetigo, could be responsible for triggering rheumatic heart disease.


You Are What You Eat At Any Age: Carbon And Nitrogen Analysis Of Mummies From An Ancient Egyptian Necropolis, Stephen Funk, R. Paul Evans Apr 2019

You Are What You Eat At Any Age: Carbon And Nitrogen Analysis Of Mummies From An Ancient Egyptian Necropolis, Stephen Funk, R. Paul Evans

Library/Life Sciences Undergraduate Poster Competition 2019

The BYU Egypt Project at Fag el-Gamus necropolis and adjacent Seila Pyramid has studied over 700 mummies excavated over the past 30 years. The necropolis includes an open area with densely located vertical burial shafts and a hill with horizontal burial shafts. The chronological and dietary history of the mummies was assessed using stable isotopy and 14C analysis of accessible biological samples.


Macrophage Infiltration And Activation In Old And Young Skeletal Muscle Following Lengthening Contractions, Jamie P. Kaluhiokalani, Jacob R. Sorensen, Robert D. Hyldahl Apr 2019

Macrophage Infiltration And Activation In Old And Young Skeletal Muscle Following Lengthening Contractions, Jamie P. Kaluhiokalani, Jacob R. Sorensen, Robert D. Hyldahl

Library/Life Sciences Undergraduate Poster Competition 2019

•Human skeletal muscle is capable of robust regeneration following damage. •Muscle repair following injury is dependent on the timely activity of pro-inflammatory (M1) and anti-inflammatory, pro-regenerative (M2) macrophages. Following acute muscle injury, healthy skeletal muscle experiences a rapid and vigorous inflammatory response. •Macrophages clear necrotic tissue and facilitate satellite cell behavior through the secretion of cytokines and growth factors. •It is known that aged muscle experiences poor regenerative potential following injury, but the cause is not well-understood.

Purpose: The purpose of this study was to investigate macrophage behavior in old and young people in the context of muscle damage.

Hypothesis ...


Industry Spotlight: Medical Devices, Evan D. Poff Jan 2019

Industry Spotlight: Medical Devices, Evan D. Poff

Marriott Student Review

Medical devices restore and even redefine health. This Industry Spotlight examines pre-market barriers, medtech business model quirks, current and future developments in the field, and the present-day move to value-based care in the medical device industry.


Beating Clusters Created With Cardiac Extracellular Matrix From Decellularized Pig Hearts And Repopulated With Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes, Isaac Myres, Bryce Allen, Silvia Moncada, Sebastian Valencia, Beverly L. Roeder, Alonzo D. Cook Jan 2019

Beating Clusters Created With Cardiac Extracellular Matrix From Decellularized Pig Hearts And Repopulated With Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes, Isaac Myres, Bryce Allen, Silvia Moncada, Sebastian Valencia, Beverly L. Roeder, Alonzo D. Cook

Library/Life Sciences Undergraduate Poster Competition 2019

Due to the high prevalence of heart disease, scarcity of donors, and high risk of transplant rejection, we aim to engineer patient specific beating cardiac patches and whole hearts for transplant.


The Role Of The Midfoot In Drop Landings, Mark T. Olsen, Dustin A. Bruening, A. Wayne Johnson, Sarah T. Ridge Jan 2019

The Role Of The Midfoot In Drop Landings, Mark T. Olsen, Dustin A. Bruening, A. Wayne Johnson, Sarah T. Ridge

All Faculty Publications

Purpose: The midfoot is instrumental to foot function; however, quantifying its roles in human movement has been difficult. A forceful dynamic activity like landing may help elucidate the midfoot’s contribution to foot energetics and function. The main purpose of this study was to measure midtarsal joint kinematics and kinetics during a barefoot single-leg landing task. A secondary aim of this study was to explore the relationship between static foot posture and dynamic midfoot function.

Methods: In a cross-sectional study design, 48 females (age = 20.4 ± 1.8 yr, body mass index = 21.6 ± 1.7 kg/m) performed drop ...


Frost450, A Novel Microtubule Targeting Agent: Resistance And Cross-Resistance In An Ovarian Cancer Cell Line, Jonathan Chancellor Fox Dec 2018

Frost450, A Novel Microtubule Targeting Agent: Resistance And Cross-Resistance In An Ovarian Cancer Cell Line, Jonathan Chancellor Fox

Undergraduate Honors Theses

Drug resistance remains problematic for chemotherapy treatments. As primary treatment strategies tend to lose potency against cancer, there is a need for treatment options that overcome drug resistance mechanisms. FROST450, a novel microtubule destabilizing agent, has proven anticancer effects that overcome taxane and multidrug resistance. However, to better understand the clinical potential of FROST450, in this study we examine the mechanisms and implications of acquired FROST450 resistance in an A2780 ovarian cancer cell line. Results indicate FROST450 resistance is associated with increased mitochondrial respiration and with changes in gene sequence or expression level of proteins associated with microtubules, and that ...


Biogeography And Natural History Of Tiger Moths And Spongillaflies Of Intermountain North America With Experimental Studies Of Host Preference In The Lichen-Feeder Cisthene Angelus (Insecta: Lepdioptera: Erebidae: Arctiinae And Neuroptera: Sisyridae), Makani Layne Fisher Dec 2018

Biogeography And Natural History Of Tiger Moths And Spongillaflies Of Intermountain North America With Experimental Studies Of Host Preference In The Lichen-Feeder Cisthene Angelus (Insecta: Lepdioptera: Erebidae: Arctiinae And Neuroptera: Sisyridae), Makani Layne Fisher

All Theses and Dissertations

The Intermountain West is comprised of impressive land formations, numerous ecoregions, and a unique biota. The area has many flora and fauna that have been investigated, but the region is generally considered undersampled when it comes to insects. However, I propose the matter to be a lack of shared experience in identifying key insect species and the underutilization of professional and personal collections. These impediments are highlighted by two insect groups in the Intermountain West: spongillaflies and tiger moths. Spongillaflies can be difficult to recognize for the general entomologist and have rarely been recorded in the Intermountain West. My colleagues ...


Biogeography And Natural History Of Tiger Moths And Spongillaflies Of Intermountain North America With Experimental Studies Of Host Preference In The Lichen-Feeder Cisthene Angelus (Insecta: Lepdioptera: Erebidae: Arctiinae And Neuroptera: Sisyridae), Makani Layne Fisher Dec 2018

Biogeography And Natural History Of Tiger Moths And Spongillaflies Of Intermountain North America With Experimental Studies Of Host Preference In The Lichen-Feeder Cisthene Angelus (Insecta: Lepdioptera: Erebidae: Arctiinae And Neuroptera: Sisyridae), Makani Layne Fisher

All Theses and Dissertations

The Intermountain West is comprised of impressive land formations, numerous ecoregions, and a unique biota. The area has many flora and fauna that have been investigated, but the region is generally considered undersampled when it comes to insects. However, I propose the matter to be a lack of shared experience in identifying key insect species and the underutilization of professional and personal collections. These impediments are highlighted by two insect groups in the Intermountain West: spongillaflies and tiger moths.Spongillaflies can be difficult to recognize for the general entomologist and have rarely been recorded in the Intermountain West. My colleagues ...


The Antimicrobial Properties Of Honey And Their Effect On Pathogenic Bacteria, Shreena Himanshu Mody Dec 2018

The Antimicrobial Properties Of Honey And Their Effect On Pathogenic Bacteria, Shreena Himanshu Mody

All Theses and Dissertations

Honey has been used to heal wounds since ancient times. There are many references in ancient literature that cite honey for its medicinal uses. It is used as an alternative agent to cure infections of wounds, burns, ulcers etc. Researchers have shown some of the antimicrobial properties of honey when used as an ointment. When applied to an affected area, it helps to promote the growth of healthy tissue. One of the factors on which the quality of the honey depends, is its geographical origin. Based on the location, honey types can vary as much as 100-fold from each other ...


Galleria Mellonella As An Alternate Infection Model For Burkholderia Species And A Comparison Of Suspension And Surface Test Methods For Evaluating Sporicidal Efficacy, Joseph D. Thiriot Dec 2018

Galleria Mellonella As An Alternate Infection Model For Burkholderia Species And A Comparison Of Suspension And Surface Test Methods For Evaluating Sporicidal Efficacy, Joseph D. Thiriot

All Theses and Dissertations

Melioidosis is a neglected tropical disease that continues unabated in many countries, particularly in Southeast Asia. There is no vaccine and antimicrobial treatment is expensive and complicated. Virulence models are important tools used to investigate genes involved in pathogenesis. Galleria mellonella is the larvae of the wax worm moth that has been used to model various infections. Based on previous studies, we attempted to establish an infection model using Burkholderia pseudomallei and Burkholderia thailandensis, a related species which is avirulent in humans. Injections of various forms of these species (fresh and frozen) were used to develop Kaplan-Meier plots. We also ...


A Sport-Specific Wearable Jump Monitor For Figure Skating, Dustin A. Bruening, Riley E. Reynolds, Chris W. Adair, Peter Zapalo, Sarah T. Ridge Nov 2018

A Sport-Specific Wearable Jump Monitor For Figure Skating, Dustin A. Bruening, Riley E. Reynolds, Chris W. Adair, Peter Zapalo, Sarah T. Ridge

All Faculty Publications

Advancements in wearable technology have facilitated performance monitoring in a number of sports. Figure skating may also benefit from this technology, but the inherent movements present some unique challenges. The purpose of this study was to evaluate the feasibility of using an inertial measurement unit (IMU) to monitor three aspects of figure skating jumping performance: jump count, jump height, and rotation speed. Seven competitive figure skaters, outfitted with a waist-mounted IMU, performed a total of 59 isolated multi-revolution jumps and their competition routines, which consisted of 41 multi-revolution jumps along with spins, footwork, and other skills. The isolated jumps were ...


Pornography’S Effect On The Brain: A Review Of Modifications In The Prefrontal Cortex, Kendra J. Muller Nov 2018

Pornography’S Effect On The Brain: A Review Of Modifications In The Prefrontal Cortex, Kendra J. Muller

Intuition: The BYU Undergraduate Journal in Psychology

Pornography use has exponentially increased in the past 10 years. Most believe pornography use is largely a harmless behavior. Although sexuality is innate, hyper-sexual behavior, such as pornography use, has become increasingly commonplace. Addiction research has found that long-term substance addiction contributes to changes in brain volume (Hong et al., 2013; Zhou et al., 2011). Recent studies have shown that behavioral addictions also have similar volume loss as substance abuse (Hong et al., 2013). Research has shown that the particular area most affected is the prefrontal cortex (Hong et al., 2013). The prefrontal cortex, which oversees regulating self-control, decreases in ...


Using Non Stem-Cells To Understand Early Tumor Growth, Jake Hogan, Heiko Enderling, Joel Brown, Robert A. Gatenby Sep 2018

Using Non Stem-Cells To Understand Early Tumor Growth, Jake Hogan, Heiko Enderling, Joel Brown, Robert A. Gatenby

Library/Life Sciences Undergraduate Poster Competition 2018

Tumors of similar size and shape can exhibit different responses to the same treatment. Targeted therapy aims to better treat these tumors by classifying them according to genotypic traits. A better understanding of how tumor traits such as non-stem cells influence tumor growth could improve targeted therapy. We hypothesize that the production of non-stem cells may aid tumor growth in avascular tumors (tumors lacking blood vessels).


The Effects Of Ice And Tens Combination Treatment On Knee And Hip Joint Neuromechanics In Individuals With Experimentally Induced Knee Pain During Running, Sunku Kwon Aug 2018

The Effects Of Ice And Tens Combination Treatment On Knee And Hip Joint Neuromechanics In Individuals With Experimentally Induced Knee Pain During Running, Sunku Kwon

All Theses and Dissertations

Context: Knee injury is a common problem for runners. Knee pain is a common symptom in knee injury and is associated with alterations in knee and hip muscle activation and hip joint angles. Relieving pain through intervention may help to restore neuromuscular function. Objective: To examine the effects of ice and transcutaneous electrical nerve stimulation (TENS) combination treatment on perceived knee pain, hip frontal plane angle, and muscle activation during running in individuals with experimental knee pain (EKP). Design: Crossover. Setting: Laboratory. Subjects: 19 participants (11 males and 8 females, 23.2 ± 1.9 y, 176 ± 11.6 cm, 71 ...


Composition Of The Community Of Small Mammals In The Great Basin Desert, Samantha Elizabeth Phillips Aug 2018

Composition Of The Community Of Small Mammals In The Great Basin Desert, Samantha Elizabeth Phillips

All Theses and Dissertations

Small mammals are a keystone guild in arid ecosystems; often exhibiting top-down control of the diversity and structure of plant communities. However, changing climate, shifting fire regimes, and the invasion of exotic plants are modifying the structure of arid systems. Environmental changes in these arid systems are likely altering small mammal communities, and therefore, their ecological role. We examined two aspects of the community composition of small mammals in the Great Basin: changes in community composition since large scale sampling of the region began in 1930, and the current population of a sensitive species of small mammal, the dark kangaroo ...


Identifying The 5’End Of The Camta1 Genes In Zebrafish, Morgan Fronk Jul 2018

Identifying The 5’End Of The Camta1 Genes In Zebrafish, Morgan Fronk

Undergraduate Honors Theses

Congenital heart diseases (CHDs) are a significant cause of infant death and are frequently caused by mutations in transcription factors. Camta1 (calmodulin binding transcription activator 1) is a transcription factor that has been proposed as a modulator in embryonic heart development and a possible cause of CHDs. The only other known member of its family in vertebrates is involved in activating a hypertrophy gene program in adult heart failure. Unlike camta2, camta1 is expressed in the embryonic heart during heart looping. However, few studies have been done on camta1. In zebrafish, there are two camta1 ohnologs (homologs created through a ...


The Diversity Found Among Carbapenem-Resistant Bacteria, Galen Edward Card Jul 2018

The Diversity Found Among Carbapenem-Resistant Bacteria, Galen Edward Card

All Theses and Dissertations

This work will look at two factors that add to the diversity of carbapenem resistant bacteria. First, it focuses on the diversity of carbapenemase resistance plasmids. 446 plasmids were characterized by size, gene content and replicon groups. We identified that on average, over 30% of the encoded proteins on each plasmid have an unknown function. Plasmid sizes ranged from 1.6kb to 500kb, with an average of around 100kb and median of 80kb. Additionally, six replicon groups account for 80% of all the carbapenemase resistance plasmids. We also highlight the lack of data available for carbapenemase carrying plasmids from bacterial ...


Passive Hallux Adduction Decreases Blood Flow To Plantar Fascia, Julia Lorene Dunbar Jul 2018

Passive Hallux Adduction Decreases Blood Flow To Plantar Fascia, Julia Lorene Dunbar

All Theses and Dissertations

Purpose: Due to the vital role that blood flow plays in maintaining tissue health, compromised blood flow can prevent effective tissue healing. An adducted hallux, as often seen inside a narrow shoe, may put passive tension on the abductor hallucis, consequently compressing the lateral plantar artery (LPA) into the calcaneus and thus restricting blood flow. The purpose of this study was to compare blood flow within the LPA before and after passive hallux adduction (PHA). Methods: Forty-five healthy volunteers (20 female, 25 male; age = 24.8 ± 6.8 yr; height = 1.7 ± 0.1 m; weight = 73.4 ± 13.5 ...


Bacteriophages For Treating American Foulbrood And The Neutralization Of Paenibacillus Larvae Spores, Thomas Scott Brady Jul 2018

Bacteriophages For Treating American Foulbrood And The Neutralization Of Paenibacillus Larvae Spores, Thomas Scott Brady

All Theses and Dissertations

The causative agent of the most devastating honeybee disease, American foulbrood (AFB), is the spore-forming bacterium Paenibacillus larvae. To prevent AFB outbreaks beekeepers prophylactically treat their hives with antibiotics even though it decreases the overall health of uninfected hives. A new treatment for AFB is needed due to recent legislation against using antibiotics, antibiotic resistance developing in P. larvae, and the resilience of P. larvae spores. Bacteriophages, or phages, are an attractive alternative to traditional antibiotics because of their specificity and ability to evolve alongside their target bacterium. In this study, two phage cocktails were developed for the treatment of ...


Genetic Basis For Elevated Rheumatic Heart Disease Susceptibility In Samoa, John Bowen Allen Jul 2018

Genetic Basis For Elevated Rheumatic Heart Disease Susceptibility In Samoa, John Bowen Allen

All Theses and Dissertations

Rheumatic heart disease is an inflammatory heart disease that affects millions of people around the world. Especially high rates of the disease can be found in Oceania, including the island nation of Samoa. Genetic studies of immune response genes have provided insight into a possible genetic link to increased susceptibility to rheumatic heart disease, including the genes that code for the toll-like receptor (TLR) protein family. One of the functions of TLR proteins is to recognize the presence of bacteria via identification of bacterial flagella. My evaluation of a Samoan family identified a variant in the TLR-5 gene that would ...


Gait Alterations And Plantar Pressure In Diabetic Peripheral Neuropathy: A Preliminary Study, Adrienne Dora Henderson Jul 2018

Gait Alterations And Plantar Pressure In Diabetic Peripheral Neuropathy: A Preliminary Study, Adrienne Dora Henderson

All Theses and Dissertations

Background: Despite a lack of consensus on its utility, clinicians have traditionally relied on plantar pressure (PP) to predict ulcer risk and prescribe interventions in individuals with diabetic peripheral neuropathy (DPN). Joint kinematics and kinetics have the potential to contribute to DPN assessment and treatment, however previous studies have not accounted for walking speed nor integrated a full-body analysis with a detailed foot model. Purpose: To assess PP and gait alterations in DPN by controlling walking speed and incorporating a multisegment foot model into a full-body gait analysis. We hypothesize that hip and ankle kinetics will be altered consistent with ...


The Clinical Significance Of Hprt As A Diagnostic And Therapeutic Biomarker For Hematological And Solid Malignancies, Michelle Hannah Townsend Jul 2018

The Clinical Significance Of Hprt As A Diagnostic And Therapeutic Biomarker For Hematological And Solid Malignancies, Michelle Hannah Townsend

All Theses and Dissertations

An estimated 1,735,350 new cancer diagnosis and 609,640 cancer related deaths are predicted to occur in the United States in 2018. To improve patient prognosis, biomarkers are needed to identify cancer in early stages. When diagnosed at an early stage, cancer is more likely to respond to treatments and patients have a higher survival rate. Consequently, there is an ever-present need to identify biomarkers that can aid in the detection of cancer. Additionally, there is a paradigm shift in the field of cancer treatment towards immunotherapy. Traditional cancer treatments include chemotherapy, radiation, and hormone therapy and are ...


Control Of Redundant Pointing Movements Involving The Wrist And Forearm, Garrett R. Dorman, Kevin C. Davis, Allan W. Peaden, Steven K. Charles Jun 2018

Control Of Redundant Pointing Movements Involving The Wrist And Forearm, Garrett R. Dorman, Kevin C. Davis, Allan W. Peaden, Steven K. Charles

All Faculty Publications

The musculoskeletal system can move in more ways than are strictly necessary, allowing many tasks to be accomplished with a variety of limb configurations. Why some configurations are preferred has been a focus of motor control research, but most studies have focused on shoulder-elbow or whole-arm movements. This study focuses on movements involving forearm pronation-supination (PS), wrist flexion-extension (FE), and wrist radial-ulnar deviation (RUD), and elucidates how these three degrees of freedom (DOF) combine to perform the common task of pointing, which only requires two DOF. Although pointing is more sensitive to FE and RUD than to PS and could ...


Synthesis Of Candidate Natural Killer T Cell Ligands, Teron Haynie, Shenglou Deng, Paul B. Savage Jun 2018

Synthesis Of Candidate Natural Killer T Cell Ligands, Teron Haynie, Shenglou Deng, Paul B. Savage

Undergraduate Honors Theses

Natural Killer T (NKT) cells are a subset of T cells that express an invariant T cell receptor (TCR) that recognizes lipid antigens in context of the CD1d molecule. CD1d presents both exogenous and endogenous glycolipids on the surface of antigen presenting cells (APCs). Multiple exogenous lipids capable of NKT cell stimulation have been characterized, but confirmed endogenous ligands are relatively few in number. Recently, a-galactosylceramides were shown to be endogenous NKT cell ligands. We have observed that a-galactosylceramides cyclize in acidic conditions. Since the biosynthetic pathway of lipid presentation via CD1d likely passes through the acidic lysosome, we propose ...


An Introductory Study Of Solid Materials For Capture And Catalysis Of Waste Stream Chemicals, Steven Kyle Butler Jun 2018

An Introductory Study Of Solid Materials For Capture And Catalysis Of Waste Stream Chemicals, Steven Kyle Butler

All Theses and Dissertations

Heterogeneous catalysts are key materials in research and industry. Herein we study two materials in different stages of development toward being applied as heterogeneous catalysts. First, MoO3SnO2 was synthesized and studied as a catalytic system similar to Sn-beta zeolites. While the Mo-based catalyst did not show similar activity to Sn-beta, it did show interesting reactivity in activating carbonyls and oxidizing organic substrates. Second, a method was developed for grafting amines onto carboxylic acid functionalized carbon nanotubes for CO2 capture. The method was successful for grafting monomer ethylamine groups onto CNT and can be further developed to allow for polymeric amine ...


Exploration Of The Gossypium Raimondii Genome Using Bionano Genomics Physical Mapping Technology, Christopher Jon Hanson Jun 2018

Exploration Of The Gossypium Raimondii Genome Using Bionano Genomics Physical Mapping Technology, Christopher Jon Hanson

All Theses and Dissertations

Cotton is a crop with a large global economic impact as well as a large, complex genome. Most industrial cotton production is from two tetraploid species (Gossypium hirsutum L. and Gossypium barbadense L.) which contain two subgenomes, specifically the AT and DT subgenomes. The DT subgenome is nearly half the size of the AT subgenome in tetraploid cotton and is closely related to an extant D-genome Gossypium species, G. raimondii Ulbr. Characterization of the structural variants present in diploid D-genome should provide greater insight into the evolution of the DT subgenome in the tetraploid cotton. Bionano (BNG) optical mapping uses ...


Characterizing The Spatial Variation Of Crop Water Productivity For Variable-Rate Irrigation Management, Jeffrey David Svedin Jun 2018

Characterizing The Spatial Variation Of Crop Water Productivity For Variable-Rate Irrigation Management, Jeffrey David Svedin

All Theses and Dissertations

Irrigated agriculture is the primary consumer of limited worldwide freshwater resources. Drought, growing world populations, and environmental demands compete with irrigation for freshwater resources"”threatening sustainable global food, fuel, and fiber production. This escalating global crisis demands that agriculture produce more food using less water. Traditional irrigation management has used technology to apply uniform irrigation rates across landscapes"”ignoring natural environmental variation. This provides inherent inefficiencies of over- or under- irrigation within individual fields. Variable-rate irrigation (VRI) is modern technology that employs global positioning systems and geographic information systems to match irrigation to spatially variable crop water demands within a ...


Biomarker Analysis And Clinical Relevance Of Thymidine Kinase 1 In Solid And Hematological Malignancies, Evita Giraldez Weagel Jun 2018

Biomarker Analysis And Clinical Relevance Of Thymidine Kinase 1 In Solid And Hematological Malignancies, Evita Giraldez Weagel

All Theses and Dissertations

Despite the global effort to discover and improve ways to detect, treat, and monitor cancer, it still remains the second leading cause of death in the United States and poses a major health and economic burden worldwide. While traditional treatments like surgery, chemotherapy, radiation therapy, and hormone therapy have been successful and have decreased cancer mortality, cancer incidence in all sites continues to rise. Consequently, there is an immediate need to find new therapeutics for the treatment of cancer. In recent years, and with the continuing push towards personalized medicine, cancer biomarkers have become crucial to detect, treat, and monitor ...