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Articles 1 - 30 of 304

Full-Text Articles in Life Sciences

P-20 Characterization Of Cgx Tautomerase And Mutants With Acetylenecarboxylic Acid, Daniel Chi, Karen Draths, Amaya Sirinimal Oct 2019

P-20 Characterization Of Cgx Tautomerase And Mutants With Acetylenecarboxylic Acid, Daniel Chi, Karen Draths, Amaya Sirinimal

Celebration of Research and Creative Scholarship

In the production of commodity chemicals through microbial synthesis, the use of renewable sugars as a raw material is increasingly common. However, this generates competition between its use in the chemical industry and the food industry. Therefore, developing alternative biosynthetic pathways involving other renewable feedstocks to replace starch-derived feedstocks is crucial. CgX, a tautomerase native to Corynebacterium glutamicum, catalyzes the hydration and subsequent decarboxylation of acetylenecarboxylic acid (ACA), a compound that can be produced from methane gas and carbon dioxide, both abundant greenhouse gases. The products formed from the CgX (wild-type)-catalyzed reaction of ACA results in a mixture of ...


Upcoming Health & Fitness Expo, Hannah Gallant Oct 2019

Upcoming Health & Fitness Expo, Hannah Gallant

Andrews Agenda: Campus News

No abstract provided.


Andreasen Center For Wellness Ribbon Cutting, Andrews University Oct 2019

Andreasen Center For Wellness Ribbon Cutting, Andrews University

Andrews Agenda: Campus News

No abstract provided.


Andreasen Center For Wellness Ribbon Cutting, Gillian Panigot Jul 2019

Andreasen Center For Wellness Ribbon Cutting, Gillian Panigot

Andrews Agenda: Campus News

No abstract provided.


Scsd Receives Grant From Parkinson Voice Project Scsd Committed To Offering Parkinson Voice Project's Speech Therapy Program In The Michiana Area, Parkinson Voice Project And Andrews University Jul 2019

Scsd Receives Grant From Parkinson Voice Project Scsd Committed To Offering Parkinson Voice Project's Speech Therapy Program In The Michiana Area, Parkinson Voice Project And Andrews University

Andrews Agenda: Campus News

No abstract provided.


Unshakeable, Dominique Gummelt, Dominique Gummelt Jun 2019

Unshakeable, Dominique Gummelt, Dominique Gummelt

Lake Union Herald

No abstract provided.


Jet Lag: What’S Light Got To Do With It?, Melissa Richardson May 2019

Jet Lag: What’S Light Got To Do With It?, Melissa Richardson

Adventist Human-Subject Researchers Association

Jet lag results in memory loss and sleepiness. Current treatments for jet lag focus on symptoms and not the cause of jet lag; disrupted light environment. This study in mice, uncovered mechanisms of how light regulates jet lag recovery and memory. This work informs our future studies in humans.


Beneficial Bugs, Winston J. Craig May 2019

Beneficial Bugs, Winston J. Craig

Lake Union Herald

No abstract provided.


Beneficial Bugs, Winston J. Craig May 2019

Beneficial Bugs, Winston J. Craig

Lake Union Herald

No abstract provided.


Spectrum Health Lakeland: Upcoming Wellness Events, Wellness Center Andrews University Apr 2019

Spectrum Health Lakeland: Upcoming Wellness Events, Wellness Center Andrews University

Andrews Agenda: Campus News

No abstract provided.


Design And Synthesis Of A Novel Lsoxazoline As A Potential Pam-Agonist, Josselyn Roosenberg Apr 2019

Design And Synthesis Of A Novel Lsoxazoline As A Potential Pam-Agonist, Josselyn Roosenberg

Honors Theses

Progression of Alzheimer's disease is associated with a loss of Ml receptor activation in the brain. However, a lack of clinical success following attempts to activate the Ml receptor at the orthosteric site has contributed to a transition towards the allosteric pocket of the receptor. Here, positive allosteric modulators (PAMs) interact to potentiate the acetylcholine response. Recent research proposes that optimization of PAM activity at the expense of intrinsic agonism may posit a means to limit adverse side effects. Therefore, this project proposes a design and synthesis of a novel isoxazoline as a potent PAM agent with weak intrinsic ...


The Impact Of Male-Exposure In The Neuronal Response Of The L3 Auditory Intemeuron To Model Calls, Shekinah Dosunmu Apr 2019

The Impact Of Male-Exposure In The Neuronal Response Of The L3 Auditory Intemeuron To Model Calls, Shekinah Dosunmu

Honors Theses

The L3 auditory neuron in female cricket Acheta domesticus responds to phonotactically attractive calls with decrement: a reduction in the number of action potentials in response to consecutive sound pulses within a chirp. Such unique response has been reported only in virgin females. This study evaluates the response of the L3 in male-exposed females to determine whether they respond to auditory stimuli differently from those exhibited by virgin female crickets.

Preliminary data indicate that L3 in young exposed female crickets responds with different decrement patterns as those reported for virgin females. The implications of these findings are discussed.


Analysis Of Dl-Amino Acid Ratios In Eggshells Using Reverse Phase-High Pressure Liquid Chromatography, Gergana Milkova Apr 2019

Analysis Of Dl-Amino Acid Ratios In Eggshells Using Reverse Phase-High Pressure Liquid Chromatography, Gergana Milkova

Honors Theses

HPLC methodology was developed to determine the concentrations and ratios of D to L amino acids in emu and ostrich eggshells treated with heat at different temperatures . We aimed to determine an internal standard and how ratios were affected under different conditions. An HPLC method was determined that gave consistent retention times and satisfactory enantioseparation . Calibration curves for each amino acid were developed from single and multi-amino acid containing dilution series producing a model that most closely replicates the eggshell-extracted amino acids.


Isolation And Characterization Of Novel Arginine-Derived Heterocyclic Amines, Nathaniel Srikureja Apr 2019

Isolation And Characterization Of Novel Arginine-Derived Heterocyclic Amines, Nathaniel Srikureja

Honors Theses

Most known heterocyclic amines (HCAs) are potent mutagens present at significant concentrations in cooked meats, and can be synthesized from burned mixtures of L-creatin(in)e with various amino acids. We hypothesize that novel mutagenic HCAs may be synthesized from a heated plant-based food simulating binary amino acid mL'\:ture: L-arginine and L-threonine. A two-part solid phase extraction was used to separate nitrogen heterocycles from byproducts followed by prep­ HPLC and the Ames mutagenicity assay using Salmonella TA98 to determine the mutagenicity of various isolates. The results indicate that this binary amino acid mixture does not yield a mutagenic sample.


Neuronal And Behavioral Response Relationships In Virgin Females Of Acheta Domesticus, Brandon Shin Apr 2019

Neuronal And Behavioral Response Relationships In Virgin Females Of Acheta Domesticus, Brandon Shin

Honors Theses

Animals that communicate acoustically serve as models for investigating how organisms respond to sound. For instance, in field crickets, females exhibit phonotaxis (directed movement towards the sound's source) to calls with a specific frequency, intensity, and syllable period (SP) - the time between the beginning of one sound pulse and the beginning of another within the same chirp. Additionally, auditory neurons in females produce action potentials in direct response to the sound pulses of a male 's call. A previous study on the species Gryllus bimaculatus demonstrated a relationship between an individual female's behavioral and neuronal responses; however, no ...


Synthesis Of An Ideal Inhibitor For The Lpxc Enzyme, Taejun Lee Apr 2019

Synthesis Of An Ideal Inhibitor For The Lpxc Enzyme, Taejun Lee

Honors Theses

Due to the growing need of antibiotics in modern day medicine, this study attempts to apply a method of medicinal chemistry that would create a novel inhibitor for a lesser known target of gram negative bacteria, the LpxC enzyme. This study proposes that a synthetic plan which consists of combining components of different molecules would create a more effective inhibitor. These components include a binding group for the active site of the enzyme, a hydrophobic chain which has been shown to interact with an allosteric site on the LpxC enzyme, and the isoxazoline ring which interacts with the zinc ion ...


The Keto Diet, Winston J. Craig Apr 2019

The Keto Diet, Winston J. Craig

Lake Union Herald

No abstract provided.


Rise Up Against Abuse Rally At Andrews, Dominique Gummelt Feb 2019

Rise Up Against Abuse Rally At Andrews, Dominique Gummelt

Andrews Agenda: Campus News

No abstract provided.


Predator-Prey Dynamics Of Bald Eagles And Glaucous-Winged Gulls At Protection Island, Washington, Usa, Shandelle M. Henson, Robert A. Desharnais, Eric T. Funasaki, Joseph G. Galusha, James W. Watson, James L. Hayward Feb 2019

Predator-Prey Dynamics Of Bald Eagles And Glaucous-Winged Gulls At Protection Island, Washington, Usa, Shandelle M. Henson, Robert A. Desharnais, Eric T. Funasaki, Joseph G. Galusha, James W. Watson, James L. Hayward

Faculty Publications

1. Bald eagle (Haliaeetus leucocephalus) populations in North America rebounded in the latter part of the twentieth century, the result of tightened protection and outlawing of pesticides such as DDT. An unintended consequence of recovery may be a negative impact on seabirds. During the 1980s, few bald eagles disturbed a large glaucous‐winged gull (Larus glaucescens) colony on Protection Island, Washington, USA, in the Salish Sea. Breeding gull numbers in this colony rose nearly 50% during the 1980s and early 1990s. Beginning in the 1990s, a dramatic increase in bald eagle activity ensued within the colony, after which began a ...


Andrews University Receives Naacls Accreditation, Hannah Gallant Jan 2019

Andrews University Receives Naacls Accreditation, Hannah Gallant

Andrews Agenda: Campus News

No abstract provided.


Chemistry & Biochemistry Guest Lecture Series, Desmond Murray Jan 2019

Chemistry & Biochemistry Guest Lecture Series, Desmond Murray

Andrews Agenda: Campus News

No abstract provided.


Investigating The Anti-Cancer Properties Of Novel Hybrid 1,4-Dihydropyridine Derivatives In U-87mg Glioblastoma Cell, Tendai Hunyenyiwa Jan 2019

Investigating The Anti-Cancer Properties Of Novel Hybrid 1,4-Dihydropyridine Derivatives In U-87mg Glioblastoma Cell, Tendai Hunyenyiwa

Master's Theses

Glioblastoma is the most devastating of brain cancers with a very high death rate and a low survival rate of less than 15 months after diagnosis. Glioblastoma is a cancer of astrocytes which are the majority of the brain glial cells that support neurons and help create the blood-brain barrier among other functions. The current approach to treating this disease is surgical removal of the main tumor, followed by radiotherapy and limited chemical intervention by the use of temozolomide (TMZ). This disease is characterized by high invasion and recurrence after surgical removal of the main tumor as a result of ...


Synthesis And Screening Of Novel Hybrid Benzothiazoles In U-87 Mg Glioblastoma Cell Line, Priscilla Kyi Jan 2019

Synthesis And Screening Of Novel Hybrid Benzothiazoles In U-87 Mg Glioblastoma Cell Line, Priscilla Kyi

Master's Theses

Benzothiazole is a heteroaromatic compound known for its wide range of bioactivities including anti-cancer, anti-viral, anti-microbial, anti-inflammatory, anti-convulsant, anti-diabetic, anti-helminthic, and anti-tubercular activities. Research has shown that derivatives of benzothiazole exhibit inhibition of proliferation via apoptosis in various human cancer cell lines, such as liver cancer (Wang, et. al., 2011). In this study, a series of novel hybrid benzothiazole α-cyanostilbene derivatives and styrylbenzothiazole derivatives containing boronic acid and non-boronic acid pharmacophores were synthesized. The anti-cancer and anti-invasive properties of selected benzothiazole α-cyanostilbene derivatives on U-87MG glioblastoma cells were investigated in vitro.

U-87MG cells were incubated with synthesized novel hybrid compounds ...


Seasonal Diet Variation In Thirteen-Lined Ground Squirrel (Ictidomys Tridecemlineatus) In Southernwestern Michigan, Austin Menzmer Jan 2019

Seasonal Diet Variation In Thirteen-Lined Ground Squirrel (Ictidomys Tridecemlineatus) In Southernwestern Michigan, Austin Menzmer

Master's Theses

Thirteen-lined ground squirrels (Ictidomys tridecemlineatus) are omnivorous ground squirrels that range from Texas to Alberta and from Michigan to Utah. The amount and type of both animal and plant matter in their diet may vary both geographically and seasonally. The present study was motivated by prior work, based on δ13C analysis of incisor enamel of thirteen-lined ground squirrels from a colony in southwestern Michigan, suggesting that these animals underwent a pronounced, late-season shift in diet from predominantly C3 to C4 plants. However, this inferred dietary shift was not directly demonstrated. Here, I tracked diet of thirteen-lined ground squirrels in southwestern ...


Healthy Holidays, Dominique Gummelt Dec 2018

Healthy Holidays, Dominique Gummelt

Lake Union Herald

No abstract provided.


Carboxypeptidase O Is A Lipid Droplet-Associated Enzyme Able To Cleave Both Acidic And Polar C-Terminal Amino Acids, Linnea C. Burke, Hazel O. Ezeribe, Anna Y. Kwon, Donnell Dockery, Peter J. Lyons Nov 2018

Carboxypeptidase O Is A Lipid Droplet-Associated Enzyme Able To Cleave Both Acidic And Polar C-Terminal Amino Acids, Linnea C. Burke, Hazel O. Ezeribe, Anna Y. Kwon, Donnell Dockery, Peter J. Lyons

Faculty Publications

Carboxypeptidase O (CPO) is a member of the M14 family of metallocarboxypeptidases with a preference for the cleavage of C-terminal acidic amino acids. CPO is largely expressed in the small intestine, although it has been detected in other tissues such as the brain and ovaries. CPO does not contain a prodomain, nor is it strongly regulated by pH, and hence appears to exist as a constitutively active enzyme. The goal of this study was to investigate the intracellular distribution and activity of CPO in order to predict physiological substrates and function. The distribution of CPO, when expressed in MDCK cells ...


Healthy Holidays, Dominique Gummelt Oct 2018

Healthy Holidays, Dominique Gummelt

Lake Union Herald

No abstract provided.


The Most Neglected Fitness Factor, Dominique Gummelt Sep 2018

The Most Neglected Fitness Factor, Dominique Gummelt

Lake Union Herald

No abstract provided.


End It Now, Melissa Ponce-Rodas Sep 2018

End It Now, Melissa Ponce-Rodas

Lake Union Herald

No abstract provided.


Running With A Purpose, Gillian Sanner Sep 2018

Running With A Purpose, Gillian Sanner

Lake Union Herald

No abstract provided.