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Full-Text Articles in Life Sciences

Obesity And Adipose Tissue Expansion In Ossabaw Swine, Richard Joel Faris Jan 2013

Obesity And Adipose Tissue Expansion In Ossabaw Swine, Richard Joel Faris

Graduate Theses and Dissertations

Obesity is characterized as a state of chronic low-grade inflammation, which originates in adipose tissue from adipocyte dysfunction as a consequence of adipocyte hypertrophy. Although rodent models have been pivotal to understanding the etiology of obesity and its co-morbidities, and the roles of specific genes, distinct differences between rodents and humans underscore the need for alternative comparative models. Swine are an attractive comparative model because of similar physiology and anatomy with humans. Ossabaw swine are of particular interest due to their "thrifty" genotype and predisposition to multiple risk factors for the metabolic syndrome.

Saturated fatty acids have the distinct ability ...


Polyphenols, Inflammation, And Cardiovascular Disease, Christy Tangney, Heather E. Rasmussen Jan 2013

Polyphenols, Inflammation, And Cardiovascular Disease, Christy Tangney, Heather E. Rasmussen

Nutrition and Health Sciences -- Faculty Publications

Polyphenols are compounds found in foods such as tea, coffee, cocoa, olive oil, and red wine and have been studied to determine if their intake may modify cardiovascular disease (CVD) risk. Historically, biologic actions of polyphenols have been attributed to antioxidant activities, but recent evidence suggests that immunomodulatory and vasodilatory properties of polyphenols may also contribute to CVD risk reduction. These properties will be discussed, and recent epidemiological evidence and intervention trials will be reviewed. Further identification of polyphenols in foods and accurate assessment of exposures through measurement of biomarkers (i.e., polyphenol metabolites) could provide the needed impetus to ...