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Theses/Dissertations

Health and environmental sciences

1990

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Full-Text Articles in Life Sciences

Dopamine Agonists Modify The Development Of Brain D1 And D2 Receptor Responsiveness, Anwar A. Hamdi May 1990

Dopamine Agonists Modify The Development Of Brain D1 And D2 Receptor Responsiveness, Anwar A. Hamdi

Electronic Theses and Dissertations

Dopamine (DA) agonist-induced behavioral supersensitivity in the adult rat has served as the standard model for certain of the motor and behavioral side effects associated with long-term exposure to DA agonists in humans. The mechanisms relating receptor events with behavior mediation, however, remain unclear. The striatum of rats progresses through a prolonged and varied postnatal developmental period. In order to examine the relative contribution of D1 and D2 receptor-mediated mechanisms to behavioral changes which follow chronic dopamine agonist exposure, developing rats were treated daily from birth with a D1 agonist, SKF 38393 hydrochloride (3.0 mg/kg $\times$ 32d, i ...


Dopamine Agonists Modify The Development Of Brain D1 And D2 Receptor Responsiveness, Anwar A. Hamdi May 1990

Dopamine Agonists Modify The Development Of Brain D1 And D2 Receptor Responsiveness, Anwar A. Hamdi

Electronic Theses and Dissertations

Dopamine (DA) agonist-induced behavioral supersensitivity in the adult rat has served as the standard model for certain of the motor and behavioral side effects associated with long-term exposure to DA agonists in humans. The mechanisms relating receptor events with behavior mediation, however, remain unclear. The striatum of rats progresses through a prolonged and varied postnatal developmental period. In order to examine the relative contribution of D1 and D2 receptor-mediated mechanisms to behavioral changes which follow chronic dopamine agonist exposure, developing rats were treated daily from birth with a D1 agonist, SKF 38393 hydrochloride (3.0 mg/kg $\times$ 32d, i ...