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Full-Text Articles in Life Sciences

Failure Of Opioids To Modify Noradrenergic Neuronal Recovery From A Dorsal Bundle Lesion In Neonatal Rats, Ellen L. Kunkel-Bagden May 1985

Failure Of Opioids To Modify Noradrenergic Neuronal Recovery From A Dorsal Bundle Lesion In Neonatal Rats, Ellen L. Kunkel-Bagden

Electronic Theses and Dissertations

Morphine and exogenous opioid peptides alter the development of central noradrenergic neurons damaged by neonatal treatment with the neurotoxin 6-hydroxydopa. Transection of the dorsal noradrenergic bundle (DNB) in neonatal rats produces nearly the same alteration in the developmental pattern. It was of interest to determine whether morphine or an exogenous opioid peptide (metenkephalin) was able to modify the recovery of noradrenergic neurons after neonatal surgical transection of the DNB. Neonatal rats were divided into two groups. Both groups received saline (0.85%) or naloxone (2.0 mg/kg) by the intraperitoneal (i.p.) route. In the first group the animals ...


Generation, Isolation And Assay Methods For Human Lymphocyte Mitogenic Factor, Thomas E. Seay Dec 1982

Generation, Isolation And Assay Methods For Human Lymphocyte Mitogenic Factor, Thomas E. Seay

Electronic Theses and Dissertations

Activated lymphocytes secrete many products including the lymphokine human lymphocyte mitogenic factor (HLMF). In preliminary experiments lymphocytes from peripheral blood and palatine tonsils were evaluated as possible sources of HLMF by evaluating their level of activation through screening their spontaneous and concanavalin A (con A)-induced blastogenic responses. Tonsil lymphocytes (TL) were found to have high spontaneous proliferation as compared to peripheral blood lymphocytes (PBL). Cells from both sources responded to con A by undergoing a typical blastogenic response. Because TL must be obtained septically, they are frequently cultured in the presence of the antimycotic agent, Amphotericin B (Am B ...


Tonsil Cell Products Which Modify In Vitro Proliferation Of Blood Lymphocytes, Thomas W. Hodge May 1982

Tonsil Cell Products Which Modify In Vitro Proliferation Of Blood Lymphocytes, Thomas W. Hodge

Electronic Theses and Dissertations

Human palatine tonsil lymphocytes, when compared to peripheral blood lymphocytes (PBL), were in an activated state even though there was no in vitro stimulation. When these tonsil lymphocytes were cultured in the absence of serum and polyclonal mitogens or antigens, the supernatant fluid often inhibited the proliferative response of target PBL to con A. The extent of this suppression ranged from 22% to 84%, and target cell viability was 90% or greater. There was no evidence for the presence of immunoglobulins or (alpha)2-macroglobulin in whole supernatant fluids. The suppressor was partially denatured at 80(DEGREES)C and was rendered ...


Enantiomeric Influences In Neuroleptic Binding To Models Of The Dopamine Receptor, Timothy A. Robert Aug 1979

Enantiomeric Influences In Neuroleptic Binding To Models Of The Dopamine Receptor, Timothy A. Robert

Electronic Theses and Dissertations

No abstract provided.