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Local Macrophage Proliferation In Adipose Tissue Is A Characteristic Of Obesity-Associated Inflammation: A Dissertation, Shinya U. Amano Mar 2013

Local Macrophage Proliferation In Adipose Tissue Is A Characteristic Of Obesity-Associated Inflammation: A Dissertation, Shinya U. Amano

GSBS Dissertations and Theses

Obesity and diabetes are major public health problems facing the world today. Extending our understanding of adipose tissue biology, and how it changes in obesity, will hopefully better equip our society in dealing with the obesity epidemic. Macrophages and other immune cells accumulate in the adipose tissue in obesity and secrete cytokines that can promote insulin resistance. Adipose tissue macrophages (ATMs) are thought to originate from bone marrow-derived monocytes, which infiltrate the tissue from the circulation. Much work has been done to demonstrate that inhibition of monocyte recruitment to the adipose tissue can ameliorate insulin resistance. While monocytes can enter ...


Role Of Inflammation In Diet-Induced Obesity: A Dissertation, Sophia Kogan Mar 2013

Role Of Inflammation In Diet-Induced Obesity: A Dissertation, Sophia Kogan

GSBS Dissertations and Theses

Obesity results from expansion of white adipose tissue. The inability of white adipose tissue to adequately store lipids leads to ectopic deposition of lipids in non-adipose tissue that can lead to systemic insulin resistance. It is well known that insulin resistance correlates with inflammation of adipose tissue in obese animals and humans. Decreasing inflammation in the adipose tissue has been proven as a therapeutic strategy for improvement of insulin sensitivity in vivo. Numerous factors secreted by immune cells, including macrophages, have been suggested as regulating adipose tissue insulin sensitivity.

In the first part of my thesis, I describe the role ...


Modulators Of The Acute Inflammatory Response: A Dissertation, Dipti Karmarkar Feb 2013

Modulators Of The Acute Inflammatory Response: A Dissertation, Dipti Karmarkar

GSBS Dissertations and Theses

Acute inflammatory response is caused by the rapid recruitment of leukocytes, mainly neutrophils and monocytes, from blood to the tissue site. Diverse agents, including invading pathogens, injured or dead cells, and other irritants, may stimulate this response. In the ensuing inflammatory response, the recruited leukocytes and their secreted molecules help in eliminating or containing the injurious agents and promoting tissue regeneration. But often this response is imprecise and can lead to bystander tissue damage. Unchecked neutrophil activation is implicated in the pathology of many inflammatory conditions. An in-depth understanding of the pathways regulating this response, therefore, becomes critical in identifying ...