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Theses/Dissertations

2013

Inflammation

Biochemistry, Biophysics, and Structural Biology

University of Iowa

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Molecular Basis Of Nod1 And Nod2 Signaling, Aaron Martin Ver Heul May 2013

Molecular Basis Of Nod1 And Nod2 Signaling, Aaron Martin Ver Heul

Theses and Dissertations

NOD1 and NOD2 (nucleotide-binding oligomerization domain-containing proteins 1 and 2) are related innate immune receptors responsible for initiating a response to bacterial infection. They belong to a class of receptors known as Pattern Recognition Receptors (PRRs), which are germline encoded immune receptors that mediate various innate immune responses. These receptors recognize conserved microbial motifs known as Pathogen-Associated Molecular Patterns (PAMPs). The PRR-PAMP paradigm forms the bedrock of how innate immunity is understood today. As two of the first intracellular PRRs discovered, NOD1 and NOD2 came to define an entire subclass of PRRs, the NOD-like receptors (NLRs). PRRs relay their signals ...