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Theses/Dissertations

2013

Applied sciences

Biomedical Engineering and Bioengineering

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Full-Text Articles in Life Sciences

The Development Of A Traumatic Brain Injury Bioreactor, Zachery Heller Dec 2013

The Development Of A Traumatic Brain Injury Bioreactor, Zachery Heller

Theses and Dissertations

Approximately 1.7 million Americans experience a traumatic brain injury (TBI) each year. Concussive injuries are a subset of TBI in which blows to the head cause the brain to collide against the interior of the skull. Damage to the neurons, supporting cells, and surrounding extra cellular matrix resulting from these collisions can lead to permanent physical, cognitive, and psychological impairment. We believe the prevalence and clinical significance of concussive injures warrants research investment. To study brain injury following TBI, in vivo models have been the gold standard for TBI experiments. Although a valuable research alternative, animals are expensive, raise ...