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Assessment Of Water Quality And Benthic Macroinvertebrate Community In A Wastewater Receiving Constructed Wetland, Jennifer Lynn Martinez Jan 2013

Assessment Of Water Quality And Benthic Macroinvertebrate Community In A Wastewater Receiving Constructed Wetland, Jennifer Lynn Martinez

Open Access Theses & Dissertations

In the El Paso region around the 1930s there was a loss of riparian areas and wetlands due to canalization of the Rio Grande. In an attempt to bring back native flora and fauna that once flourished in the floodplain of the Rio Grande region, the creation of Rio Bosque Wetlands Park (RBWP; El Paso Co., TX) was initiated in 1995. As part of the construction agreement, El Paso Water Utilities agreed to provide water to fill the wetland upon its completion. Beginning in 1998, RBWP was filled with treated effluent from the adjacent Roberto Bustamante Wastewater Treatment Plant (WWTP ...


Manufacturing Nerve Guidance Conduits By Stereolithography For Use In Peripheral Nerve Regeneration, Mireya Aidee Perez Jan 2013

Manufacturing Nerve Guidance Conduits By Stereolithography For Use In Peripheral Nerve Regeneration, Mireya Aidee Perez

Open Access Theses & Dissertations

Nerve regeneration techniques have been studied in great depth in recent years. Peripheral nerve injuries, in particular, can be caused by accidents, falls, athletic injuries, etc. Current methods of repair include direct suturing of the 2 injured nerve ends or the use of autografts, when a nerve section is taken from another area of the body. Both methods have a series of limitations which have led researchers to study alternative methods of repair. Nerve guidance conduits may provide a viable solution because they can be modified and adapted to the patient's needs. Some conduits already exist on the market ...


Genetic Diversity In Populations Of Epiphanes Chihuahuaensis (Rotifera: Monogononta) In The Northern Chihuahuan Desert, Diego E. Reyes Jan 2013

Genetic Diversity In Populations Of Epiphanes Chihuahuaensis (Rotifera: Monogononta) In The Northern Chihuahuan Desert, Diego E. Reyes

Open Access Theses & Dissertations

1. Cryptic speciation in zooplankton is a phenomenon that has been recently gaining much attention. This is due in part to advances in molecular techniques which help in the identification of morphologically indistinct species. Organisms that have been traditionally believed to have cosmopolitan distributions are being found to be composed of cryptic species complexes with high levels of genetic divergence among lineages.

2. Epiphanes chihuahuaensis is a member in the Epiphanes senta species complex. In a previous study by Schröder & Walsh (2007), genetic data, along with morphological and reproductive isolation data were employed to help delineate four species within the ...


Examining Articulatory Kinematics Using Diadochokinesis In Concussed And Non-Concussed Individuals, Lindsay Deann Dolan Jan 2013

Examining Articulatory Kinematics Using Diadochokinesis In Concussed And Non-Concussed Individuals, Lindsay Deann Dolan

Open Access Theses & Dissertations

ABSTRACT

Cognitive and communicative deficits associated with traumatic brain injury are an active area of research. However, no research to date has reported on the functionality of motor speech following a concussion. A common tool used to evaluate the motor speech status of potentially impaired individuals is the measurement of the diadochokinetic speech rate. The purpose of this study is to investigate diadochokinetic speech rates in individuals who experience a sports-related concussion. Determining the nature and extent of motor speech involvement post concussion will contribute to the diagnosis, prognosis, and management of recovery. The present investigation will determine; (i) if ...


Regulation Of The Glycine Transporter 1 (Glyt1) By Pkca-Dependent Ubiquitination, Susana Barrera Jan 2013

Regulation Of The Glycine Transporter 1 (Glyt1) By Pkca-Dependent Ubiquitination, Susana Barrera

Open Access Theses & Dissertations

Glycine is one of the major inhibitory neurotransmitters in the central nervous system. It is implicated in the regulation of motor-sensory function such as; pain perception, reflex responses, and is essential for early development of the CNS. In addition to its inhibitory actions, it acts as an obligatory co-agonist for the activation of glutamatergic NMDARs, which are of pivotal importance in the process of learning and memory, its dysfunction leads to several neurodegenerative diseases. Two high affinity Na+/Cl- dependent transporters GlyT1 and GlyT2 tightly regulate the availability of glycine present at the synapse for the activation of NMDARs and ...


Endocrine Disrupting Compound 4-Nonylphenol And Neurodegeneration, Jessica Martinez Jurado Jan 2013

Endocrine Disrupting Compound 4-Nonylphenol And Neurodegeneration, Jessica Martinez Jurado

Open Access Theses & Dissertations

Neurodegeneration, a progressive loss of nerve cells (neurons), occurs in many neurological disorders including Alzheimer's disease, Parkinson's disease, Schizophrenia, and drug addiction. Cytoskeletal disruption in neurons and aggregation of proteins associated with these disorders is the hallmark of neurodegeneration. However, the cause of neurodegenerative disorders is unknown and currently there are no effective drug treatments. Aging is the most consistent risk factor for developing a neurodegenerative disorder, and recent evidence suggests that environmental factors, which act as endocrine disruptors, pose a risk in the disease process. 4- nonylphenol (4-NP), an endocrine-disrupting compound (EDC), has been shown to affect ...


Validation Of N-Myristoyltransferase As Potential Chemotherapeutic Target In Chagas Disease, Linda Herrera Jan 2013

Validation Of N-Myristoyltransferase As Potential Chemotherapeutic Target In Chagas Disease, Linda Herrera

Open Access Theses & Dissertations

The protozoan parasite Trypanosoma cruzi is the etiological agent of Chagas disease, a problem endemic to Central and South America. In recent years, this neglected infectious disease has become a global health concern. The only clinically available drugs for the chemotherapy of Chagas disease have important disadvantages such as, high toxicity, strain resistance and variable efficacy. Therefore, there is an urgent need for the development of new antichagasic agents. The enzyme N-myristoyltransferase (NMT) has been characterized in a range of eukaryotes, from Saccharomyces cerevisae to Homo sapiens. Moreover, NMT has been shown to be essential in protozoan parasites, including Leishmania ...


Ruthenium-Azole Complexes As Chemotherapeutic Agents Against Leishmaniasis, Eva Iniguez Jan 2013

Ruthenium-Azole Complexes As Chemotherapeutic Agents Against Leishmaniasis, Eva Iniguez

Open Access Theses & Dissertations

Leishmaniasis is a neglected disease that affects millions of people worldwide. Poor efficacy and high toxicity of the limited treatment options demonstrate the need for the development of new chemotherapeutic agents to treat this disease. In order to respond this concern, the development of novel Ru-azole complexes as chemotherapeutic agents by inhibiting the cytochrome P-450 dependent C14-α-demethylation of lanosterol to ergosterol which is essential for the parasite survival. In addition, Ruthenium would enhance the activity of the parental drug, by helping ketoconazole/clotrimazole to cross the parasite membrane, together presenting low toxicity. The viability and citotoxicity of the Ru-azole compunds ...


The Threat Of Domestic Bioterrorism: Fact Or Fiction, Stacy M. Langston Jan 2013

The Threat Of Domestic Bioterrorism: Fact Or Fiction, Stacy M. Langston

Open Access Theses & Dissertations

The threat of a domestic bioterrorist attack can be a daunting issue to cover. Using the analytic technique What If? Analysis a scenario was created for a domestic bioterrorism attack in Houston, TX. Indicators were developed to determine how to mitigate and respond to the attack. Recommendations were provided following the attack that can be used to prevent future attacks that were conducted in the scenario. Having a hindsight view of an attack is the best way to prevent and respond to the attack.


Comparison Of Ectoparasitic Mite Loads Between Gonochoristic (Aspidoscelis Marmorata) And Parthenogenic (A. Tesselata) Syntopic Whiptail Lizards (Teiidae) From The Northern Chihuahuan Desert Of Trans-Pecos, Texas, William Dawson Lukefahr Jan 2013

Comparison Of Ectoparasitic Mite Loads Between Gonochoristic (Aspidoscelis Marmorata) And Parthenogenic (A. Tesselata) Syntopic Whiptail Lizards (Teiidae) From The Northern Chihuahuan Desert Of Trans-Pecos, Texas, William Dawson Lukefahr

Open Access Theses & Dissertations

The objective of this study was to compare the ectoparasitic loads between two syntopic whiptail lizard species (Teiidae) that differ in their reproductive modes; Aspidoscelis marmorata (bisexual) and A. tesselata (unisexual). The study site was located on Indio Mountains Research Station (IMRS) in a Chihuahuan Desert Scrub landscape in Hudspeth County, Texas. Previous studies conducted at IMRS showed the two species having similar diets, morphology, and reproductive characteristics, but fluctuated in nematode loads. No comparative study of ecotoparasitic mites (Eutrombicula alfreddugesi) between the two species has ever been done.

Aspidoscelis marmorata (n = 141) and A. tesselata (n = 144) were captured ...


Giardia Lamblia: Regulation Of Cyst Production By Glycosphingolipids, Tavis Lyle Mendez Jan 2013

Giardia Lamblia: Regulation Of Cyst Production By Glycosphingolipids, Tavis Lyle Mendez

Open Access Theses & Dissertations

The diplomonad protist, Giardia lamblia, colonizes and replicates in the small intestine of mammals. In humans, Giardia infection (known as giardiasis) can be symptomatic or asymptomatic with the former being associated with fatty stool, abdominal pain, malnutrition, and weight loss. Both cell-mediated and humoral immune responses against Giardia infection are possible, and adaptive responses have been reported to be important for controlling the infection. Non-immune components such as secretory immunoglobulin, intestinal lipids, and bile acids also play significant roles in determining the severity of the infection by Giardia.

Giardia exists in two morphologic forms--trophozoites and cysts--and maintains a simple life ...


Changes In Net Ecosystem Production Over The Past 40 Years In Arctic Tundra Ponds Near Barrow, Alaska: Application Of Historic And Modern Techniques, Nickole Ann Miller Jan 2013

Changes In Net Ecosystem Production Over The Past 40 Years In Arctic Tundra Ponds Near Barrow, Alaska: Application Of Historic And Modern Techniques, Nickole Ann Miller

Open Access Theses & Dissertations

Arctic environments have gained interest recently due to their sensitivity to climate change. As warming has created longer growing seasons, extended ice-free periods as well as permafrost thaw, the production in freshwater ecosystems has the potential to be greatly impacted. It is hypothesized that as climate change and warming occurs, increases in primary production will occur and ponds will become carbon sinks. Net ecosystem production (NEP) was determined using phytoplankton and periphyton samples collected weekly during the growing season (June - August) from arctic tundra ponds near Barrow, Alaska. Enrichment with 14C was used to determine both weekly photosynthetic rates and ...


Novel Copper (Ii) Mediated Transfection Nano-Systems And Biological Properties Of Pyridinium Surfactants, Sarit Pal Jan 2013

Novel Copper (Ii) Mediated Transfection Nano-Systems And Biological Properties Of Pyridinium Surfactants, Sarit Pal

Open Access Theses & Dissertations

Efficacy of gene therapy is relied upon the improvement of gene delivery vectors into mammalian cells. Although viral-based polynucleotide carriers are still considered as the most common method for gene delivery but the cost effectiveness, nonspecific lethal immune response has evoked the renaissance of non-viral synthetic delivery systems. An initial discovery by Felgnar et al showed Cationic Liposomes (CLs) (having an overall positive charge) when mixed with DNA to form CL-DNA complexes can enhance the transfer of polynucleotides into cells followed by its expression. Presently, a flurry of experimental works is taking place for the better understanding of structural characterization ...


Refining Molecular Approaches For Bacterial Source Tracking (Bst) In Texas, Joy Truesdale Jan 2013

Refining Molecular Approaches For Bacterial Source Tracking (Bst) In Texas, Joy Truesdale

Open Access Theses & Dissertations

Bacterial source tracking (BST) is a new science that aids in identifying sources of human and animal fecal contamination of environmental water. There are currently two approaches used in BST, library-dependent and library-independent methods. The fecal bacterium E. coli is often used in library dependent methods because it indicates fecal contamination, has been used in human health risk assessments, and has water quality regulatory significance. A disadvantage of E. coli library dependent BST methods is that identification libraries of E. coli isolated from known fecal sources are needed to identify the sources of E. coli isolated from water samples. Further ...


Automatic Elucidation Of Gpi Molecular Structures With Grid Computing Technology, Juan Clemente Aguilar Bonavides Jan 2013

Automatic Elucidation Of Gpi Molecular Structures With Grid Computing Technology, Juan Clemente Aguilar Bonavides

Open Access Theses & Dissertations

Glycosylphosphatidylinositol (GPI)-anchored proteins are involved in many biological processes and are of medical importance. The identification and analysis of the entire collection of free and protein-linked GPIs within an organism (i.e., GPIomics) requires highly sensitive instruments. At present, liquid chromatography-tandem mass spectrometry (LC-MS/MS or -MSn) is the most efficient laboratory technique for these tasks. As a typical MSn experiment produces hundreds of thousands of spectra, the data analysis creates a major bottleneck in high-throughput GPIomic projects. Yet, no computational tool for characterizing the chemical structures of GPI is available to date. We propose a library-search ...


Modeling The Human Gait Phases Using Granular Computing, Melaku Ayenew Bogale Jan 2013

Modeling The Human Gait Phases Using Granular Computing, Melaku Ayenew Bogale

Open Access Theses & Dissertations

Gait analysis is applied for the provision of diagnosis, evaluation, and for the design of therapeutic intervention for subjects suffering from neurological disorders. The benefits accruing from gait analysis are well established. People with neurological disorders like mild traumatic brain injury, Cerebral Palsy and Multiple Sclerosis, suffer associated functional gait problems. The symptoms and sign of these gait deficits are different from subject to subject and even for the same subject at different stage of the disease. Identifying these gait related abnormalities helps in the treatment planning and rehabilitation process.

The dynamic behavior of gait parameters is cyclic and the ...


The Effect Of Exogenous Leptin On Dendritic Cell Migration And Interactions With T Cells, Amanda L. Gonzales Jan 2013

The Effect Of Exogenous Leptin On Dendritic Cell Migration And Interactions With T Cells, Amanda L. Gonzales

Open Access Theses & Dissertations

Obesity is a complex, chronic disease that has reached epidemic proportions in the United States and shows no indication of receding. It is a state of chronic low-grade inflammation that is initiated by morphological changes in large accumulations of adipose tissue. Leptin is a pleiotropic hormone secreted by adipose tissue, presenting a possible link between obesity and inflammation. In this study, we assessed the effect of leptin on bone marrow-derived (BM) dendritic cells (DC) (BM-DC) function, antigen presenting cells vital for the activation of naí¯ve T cells. Previous data produced in our laboratory established that the addition of leptin ...


Role Of Post-Translational Modifications In The Hiv Cofactor Activity Of Ledgf/P75, Denisse Adriana Gutierrez Jan 2013

Role Of Post-Translational Modifications In The Hiv Cofactor Activity Of Ledgf/P75, Denisse Adriana Gutierrez

Open Access Theses & Dissertations

see document.


An Intra-Individual Event-Related Potential-Based Concealed Attitude Test, David R. Herring Jan 2013

An Intra-Individual Event-Related Potential-Based Concealed Attitude Test, David R. Herring

Open Access Theses & Dissertations

The evaluative oddball is an implicit measure for detecting (concealed) attitudes. In evaluative oddball studies, low occurrence stimuli such as negative pictures are presented among high occurrence context stimuli such as positive pictures. Late positive potentials (LPPs) of the event-related potential (ERP) are larger to evaluatively incongruent stimuli such as negatives compared to congruent stimuli such as positives with the context (e.g., positives). In prior evaluative oddball paradigms, this evaluative congruity effect of the LPP was reduced when participants concealed compared to truthfully reported attitudes. Because prior evaluative oddballs have been focused on the group level analysis, it has ...


A Revision Of The New World Ants Of The Genus Platythyrea Roger 1863 (Hymenoptera: Formicidae), Mayra Janett Leyva Jan 2013

A Revision Of The New World Ants Of The Genus Platythyrea Roger 1863 (Hymenoptera: Formicidae), Mayra Janett Leyva

Open Access Theses & Dissertations

The genus Platythyrea consists of arboreal ants that are rarely collected. The genus was last partially revised in 1975 by Brown. Since that revision two additional species have been described. The New World genus Platythyrea now includes nine species: P. angusta Forel, P. exigua Kempf, P. lenca De Andrade, P. pilosula (Smith), P. prizo Kugler, P. punctata (Smith), P. sinuata (Roger), P. strenua Wheeler and P. zodion Brown. A new key, illustrations, diagnoses and distributions of the ants are provided.


Method Development For A Chemical And Biological Analysis Of Glucocorticoids In Wastewater, Maria Carmen Lozano Jan 2013

Method Development For A Chemical And Biological Analysis Of Glucocorticoids In Wastewater, Maria Carmen Lozano

Open Access Theses & Dissertations

Glucocorticoids are a class of steroid hormones that can either be produced synthetically or naturally by the adrenal glands. The synthetic glucocorticoids are highly prescribed in the United States for their anti-inflammatory and immunosuppressive properties to treat a variety of ailments and diseases; however, these have been implicated in a number of adverse human conditions such as obesity, metabolic syndrome, immune-suppression, delayed puberty, adrenal insufficiency and Cushing Syndrome, among others. Ongoing research has shown that synthetic and natural hormones are transported to aquatic environments via mammalian excretion or wastewater effluent, and as a result, the release of glucocorticoids into the ...


Sumoylation Exerts Minimal Effects On The Splicing Regulatory Activity Of The Influenza A Virus Non-Structural Protein Ns1, Griselda Melendez Jan 2013

Sumoylation Exerts Minimal Effects On The Splicing Regulatory Activity Of The Influenza A Virus Non-Structural Protein Ns1, Griselda Melendez

Open Access Theses & Dissertations

One of the greatest challenges facing the development of a universal treatment for influenza infection is the virus's ability to mutate rapidly and produce new antigenic properties. Targeting the viral components of one strain does not ensure that the treatment will be effective with a newly developed strain. One alternative would be to develop therapies that target cellular factors the virus depends on for survivability. One of these factors is the cellular SUMOylation system. We have previously demonstrated that the Small Ubiquitin-like MOdifier (SUMO) interacts with the influenza virus by SUMOylating several viral proteins and by affecting the interferon ...


Identification Of Kinase Signaling Pathways Inducing Morphological Changes In Dendritic Cells Upon Leptin Treatment, Marisol Ann O'Neill Jan 2013

Identification Of Kinase Signaling Pathways Inducing Morphological Changes In Dendritic Cells Upon Leptin Treatment, Marisol Ann O'Neill

Open Access Theses & Dissertations

Leptin is a pleiotropic hormone secreted by white adipose tissue. Obesity leads to overexpression of leptin as a result of leptin receptor desensitization. Obese leptin serum levels (160ng/ml) have been found to enhance immune functions in macrophages, natural killer cells, B cells, T cells, and dendritic cells. Previous data from our lab suggests that obese concentrations of leptin cause morphological changes in DCs, although further studies are required to verify these results. We hypothesized that leptin promotes DC cytoskeletal changes though activation of PI3K signaling. Morphological and functional changes were evaluated in JAWS II immortalized DCs though microscopy, transwell ...


Validating The Adidas Micoach And Nike+ Sport Kit For Estimating Pace, Distance And Energy Expenditure During Over-Ground Exercise, Justin Paul Porta Jan 2013

Validating The Adidas Micoach And Nike+ Sport Kit For Estimating Pace, Distance And Energy Expenditure During Over-Ground Exercise, Justin Paul Porta

Open Access Theses & Dissertations

There is currently no known published research validating the Adidas miCoach or Nike+ Sport Kit personal training systems for outdoor, over-ground walking and running. To validate these devices for estimating pace (min.km-1), distance (km) and energy expenditure (EE) (kcal·min-1) during outdoor over-ground walking and running for two different sensor configurations, 6 male and 8 female participants with moderate endurance training (Mean ± SE Age: 28.21 ± 2.27 y; Body Mass: 60.93 ± 2.97 kg; Height: 167.43 ± 2.09 cm; Percent Body Fat: 14.93 ± 1.94% (N=16); and VO2max: 54.44 ± 1.47 mL·kg-1 ...


Assessing Naturalistic Decision Making By Experienced And Inexperienced Interrogators In High Stakes Interviews, Amy Bethany Ross Jan 2013

Assessing Naturalistic Decision Making By Experienced And Inexperienced Interrogators In High Stakes Interviews, Amy Bethany Ross

Open Access Theses & Dissertations

The current thesis aimed to improve the ecological validity of human intelligence interrogation research. Although field practitioners and researchers have worked together to improve the scientific validity and practical execution of interrogation techniques, research has yet to understand how, when and why interrogators implement such techniques. This thesis investigated the active decision making processes of interrogators that occur during high value interrogations. The theory of Naturalistic Decision Making was used to capture the naturalistic characteristics of high value interrogations- ambiguity, time pressure and high stakes. To capture the decision-making processes that are associated with skilled performance, this research conducted in-depth ...


Influences Of Ecological Light Pollution On Advertisement Calls Of Spea Multiplicata (Amphibia: Anura: Scaphiopodidae) In Rural And Urban Populations In The Northern Chihuahuan Desert And An Evaluation Of Hybrid S. Bombifrons X S. Multiplicata Calls, Katie Anderson Jan 2013

Influences Of Ecological Light Pollution On Advertisement Calls Of Spea Multiplicata (Amphibia: Anura: Scaphiopodidae) In Rural And Urban Populations In The Northern Chihuahuan Desert And An Evaluation Of Hybrid S. Bombifrons X S. Multiplicata Calls, Katie Anderson

Open Access Theses & Dissertations

Spea is a genus of toad-like, arid adapted frogs distributed throughout much of the western U.S. and northern Mexico. Two species, (S. Bombifrons and S. Multiplicata) are syntopic throughout most of the northern Chihuahuan Desert, a region that is experiencing rapid urbanization. For this study, I examined 936 male advertisement calls from urban and rural populations of S. multiplicata, and a rural population of S. bombifrons in west Texas and south-central New Mexico. Advertisement calls from urban and rural S. multiplicata were compared against light level to assess the potential influence ecological light pollution plays in sexual selection at ...


The Mediating Role Of Dietary Patterns On The Relation Between Acculturation, Psychosocial Factors, And Cardiovascular Disease Risk Factors In The U.S. - Mexico Border, Ximena Burgos Jan 2013

The Mediating Role Of Dietary Patterns On The Relation Between Acculturation, Psychosocial Factors, And Cardiovascular Disease Risk Factors In The U.S. - Mexico Border, Ximena Burgos

Open Access Theses & Dissertations

Chronic diseases affect both, developed and developing countries around the world. In the U.S., cardiovascular diseases (CVD) are the leading cause of death for all groups including Hispanics (Heron, 2009). Hispanics are disproportionally affected by CVD and experience risk factors at higher rates than non-Hispanic whites (Swenson, 2002). Although CVD are among the most expensive and widespread health problems, they are among the most preventable. Evidence shows that diet plays a very important role in the development of chronic diseases; current dietary changes are partially responsible for the increasing epidemic of chronic diseases worldwide. It is well established that ...


Expression And Characterization Of The Major Capsid Protein (Mcp) Of A Giant Marine Virus: Cafeteria Roenbergensis Virus, Sayan Chakraborty Jan 2013

Expression And Characterization Of The Major Capsid Protein (Mcp) Of A Giant Marine Virus: Cafeteria Roenbergensis Virus, Sayan Chakraborty

Open Access Theses & Dissertations

The oceans play significant roles in maintaining the climate on Earth and providing nutrients to the whole biosphere. Oceanic microbes produce approximately half of the Earth's oxygen. It has been shown that the populations of microbial communities in oceans are largely regulated by viral infection and thus affect the marine ecosystem. Cafeteria roenbergensis Virus (CroV) is a giant marine virus with a linear, double stranded, and AT-rich DNA genome. The genome of CroV has a size of 744kb and encodes for 544 predicted genes. CroV derived its name from its host, a unicellular marine zooplankton Cafeteria roenbergensis (Cro) that ...


Guilty By Association: Time-Dependent Memory Consolidation And The Generalization Of Person-Specific Traits To Other Group Members, Luke R. Enge Jan 2013

Guilty By Association: Time-Dependent Memory Consolidation And The Generalization Of Person-Specific Traits To Other Group Members, Luke R. Enge

Open Access Theses & Dissertations

The following study investigated the extent to which time-dependent memory consolidation facilities the generalization of person-specific traits (individuated targets) to other, familiar social group members (familiar targets) Sixty-Nine (N = 69) participants learned to distinguish between two arbitrary groups, one positive and one negative. Participants learned the negative or positive information about a subset of the group members (individuated targets) and no individuating information about the familiar targets. Participants returned either without a time-delay containing sleep (2-6 hours after learning) or a time-delay with sleep (48 hours after learning). Results demonstrated that only after a time-delay containing sleep, negative information was ...


Identification Of Chemotherapeutic Agents Against Leishmaniasis And Chagas' Disease, Miguel Abran Vasquez Jan 2013

Identification Of Chemotherapeutic Agents Against Leishmaniasis And Chagas' Disease, Miguel Abran Vasquez

Open Access Theses & Dissertations

Patients with clinical manifestations of leishmaniasis and Chagas' disease rely on few drugs that have limited efficacy and considerable side effects. Expanding the diversity of available chemotherapeutic drugs for these diseases is of extreme medical importance. Enones or á,í¢-unsaturated ketones, initially developed as anti-cancer agents, are a worthy of class of compounds to test for activity against Leishmania major and Trypanosoma cruzi as these eukaryotic parasites share many of the characteristics exhibited by cancer cells. The anti-parasitic activity of a library of á,í¢-unsaturated ketones (136 derivatives) was screened against L. major as well as in mammalian ...