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Theses/Dissertations

2013

Graduate Theses and Dissertations

Vaccine

Virology

Articles 1 - 2 of 2

Full-Text Articles in Life Sciences

Porcine Reproductive And Respiratory Syndrome Virus: Diagnostic Update And Search For Novel Modified Live Vaccines, Joshua Scott Ellingson Jan 2013

Porcine Reproductive And Respiratory Syndrome Virus: Diagnostic Update And Search For Novel Modified Live Vaccines, Joshua Scott Ellingson

Graduate Theses and Dissertations

Porcine reproductive and respiratory syndrome virus continues to be a significant problem for pork producers. The aim of this body of work was to help stakeholders control and prevention infection with this virus. A literature review of currently available diagnostic tests and guidelines for their interpretation serves as a resource for producers, practitioners, and researchers. The research focus was to evaluate two novel methods to develop improved modified live vaccines. The efficacy of viral chimeras constructed from a commercially available vaccine and a virulent wild-type isolate and the ability to attenuate wild-type isolates with a unique cell passage process are ...


Utilities Of Reverse Genetics System As A Platform For The Development Of Porcine Reproductive And Respiratory Syndrome (Prrs) Virus Vaccine, Dong Sun Jan 2013

Utilities Of Reverse Genetics System As A Platform For The Development Of Porcine Reproductive And Respiratory Syndrome (Prrs) Virus Vaccine, Dong Sun

Graduate Theses and Dissertations

Porcine reproductive and respiratory syndrome virus (PRRSV) causes reproductive disorder in breeding pigs and respiratory symptoms in pigs of all ages. The virus continues to bring significant economic losses to swine industry, and is considered to be one of the most important swine pathogens. Vaccination has been utilized to aid or facilitate PRRS control. Among various types of vaccines used, attenuated live virus vaccines appear to be more efficacious than killed virus vaccines. However, the effect of vaccination with attenuated live virus vaccines is crippled by several safety and efficacy issues. First, the vaccine development process is time-consuming. Second, the ...