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Theses/Dissertations

2013

Graduate Theses and Dissertations

Vaccine

Medical Specialties

Articles 1 - 2 of 2

Full-Text Articles in Life Sciences

Mechanisms Of Immunity And Pathology During Canine Leishmaniasis: Leading The Way To Prevention And Treatment, Kevin Jan Esch Jan 2013

Mechanisms Of Immunity And Pathology During Canine Leishmaniasis: Leading The Way To Prevention And Treatment, Kevin Jan Esch

Graduate Theses and Dissertations

Visceral leishmaniasis (VL) caused by certain species of the genus Leishmania results in a significant disease burden worldwide. This is most pronounced in some of the world's poorest communities. In South America and the Mediterranean basin, dogs are the major domestic reservoir for Leishmania infantum, one cause of human VL. In addition, dogs infected with L. infantum have an immune response and pathophysiology similar to human cases, making them a representative naturally-occurring animal model of VL. Chronic infection with Leishmania infantum can result in asymptomatic infection for a long period of time or symptomatic, potentially life-threatening visceralizing disease. Immunopathology ...


Polyanhydride Particle Platform For Design Of Novel Influenza Vaccines, Lucas Mark Huntimer Jan 2013

Polyanhydride Particle Platform For Design Of Novel Influenza Vaccines, Lucas Mark Huntimer

Graduate Theses and Dissertations

Vaccines remain the most effective medical intervention to disease in which effective vaccines are available. Designing vaccines that elicit protective immunity while minimizing adverse events is difficult. Exacerbating the challenges of vaccine design is the increased emphasis on using pure preparation of antigens that alleviate safety concerns but also show decreased potency. Therefore the need for safe adjuvants to boost immunity of subunit immunizations is great. This work demonstrates the capability of a novel bio-erodible polyanhydride particle platform to enhance humoral and cellular immunity. Encapsulation of 25 µg of Ovalbumin (Ova) antigen in microparticles elicits humoral immune responses equivalent to ...