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Theses/Dissertations

2013

Graduate Theses and Dissertations

Vaccine

Immunology and Infectious Disease

Articles 1 - 4 of 4

Full-Text Articles in Life Sciences

Mechanisms Of Immunity And Pathology During Canine Leishmaniasis: Leading The Way To Prevention And Treatment, Kevin Jan Esch Jan 2013

Mechanisms Of Immunity And Pathology During Canine Leishmaniasis: Leading The Way To Prevention And Treatment, Kevin Jan Esch

Graduate Theses and Dissertations

Visceral leishmaniasis (VL) caused by certain species of the genus Leishmania results in a significant disease burden worldwide. This is most pronounced in some of the world's poorest communities. In South America and the Mediterranean basin, dogs are the major domestic reservoir for Leishmania infantum, one cause of human VL. In addition, dogs infected with L. infantum have an immune response and pathophysiology similar to human cases, making them a representative naturally-occurring animal model of VL. Chronic infection with Leishmania infantum can result in asymptomatic infection for a long period of time or symptomatic, potentially life-threatening visceralizing disease. Immunopathology ...


Polyanhydride Particle Platform For Design Of Novel Influenza Vaccines, Lucas Mark Huntimer Jan 2013

Polyanhydride Particle Platform For Design Of Novel Influenza Vaccines, Lucas Mark Huntimer

Graduate Theses and Dissertations

Vaccines remain the most effective medical intervention to disease in which effective vaccines are available. Designing vaccines that elicit protective immunity while minimizing adverse events is difficult. Exacerbating the challenges of vaccine design is the increased emphasis on using pure preparation of antigens that alleviate safety concerns but also show decreased potency. Therefore the need for safe adjuvants to boost immunity of subunit immunizations is great. This work demonstrates the capability of a novel bio-erodible polyanhydride particle platform to enhance humoral and cellular immunity. Encapsulation of 25 µg of Ovalbumin (Ova) antigen in microparticles elicits humoral immune responses equivalent to ...


Exercise-Mediated Changes In Plasmacytoid Dendritic Cell Production Of Ifnα And The Effects Of Moderate Intensity Exercise On Immune Response To Influenza Infection And Influenza Vaccine, Justus Hallam Jan 2013

Exercise-Mediated Changes In Plasmacytoid Dendritic Cell Production Of Ifnα And The Effects Of Moderate Intensity Exercise On Immune Response To Influenza Infection And Influenza Vaccine, Justus Hallam

Graduate Theses and Dissertations

Epidemiological studies suggest that moderate exercise is associated with improved resistance to infection; it has also been shown that acute exhaustive exercise is associated with increased susceptibility to infection, particularly upper respiratory tract infections. Seasonal influenza virus is a contagious upper respiratory tract infection that can lead to widespread morbidity and mortality each year, despite the availability of a vaccine for influenza. Type I interferons (IFNs) are one of the body's first lines of defense against viral infection. Influenza vaccines containing interferon-alpha (IFNa) have been shown to increase antigen-specific antibody titer. The purpose of the experiments carried out in ...


Synthetic Nanoparticle-Based Vaccines Against Respiratory Pathogens, Kathleen Alaine Ross Jan 2013

Synthetic Nanoparticle-Based Vaccines Against Respiratory Pathogens, Kathleen Alaine Ross

Graduate Theses and Dissertations

Avian influenza A H5N1 is rapidly gaining the potential to be the next influenza pandemic threat. Human cases of H5N1 have proven to be approximately 60% fatal with a growing number of strains becoming resistant to antiviral treatments. Therefore, there is a strong need for new research to develop a pandemic H5N1 avian influenza vaccine. In this work, a synthetic polyanhydride nanoparticle-based vaccine (or nanovaccine) platform for respiratory pathogens such as H5N1 was designed. In particular, the work focused on the design of a subunit vaccine based on antigens specific to H5N1 avian influenza.

Intranasal administration of vaccines can increase ...