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Theses/Dissertations

2013

Graduate Theses and Dissertations

Vaccine

Chemical Engineering

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Synthetic Nanoparticle-Based Vaccines Against Respiratory Pathogens, Kathleen Alaine Ross Jan 2013

Synthetic Nanoparticle-Based Vaccines Against Respiratory Pathogens, Kathleen Alaine Ross

Graduate Theses and Dissertations

Avian influenza A H5N1 is rapidly gaining the potential to be the next influenza pandemic threat. Human cases of H5N1 have proven to be approximately 60% fatal with a growing number of strains becoming resistant to antiviral treatments. Therefore, there is a strong need for new research to develop a pandemic H5N1 avian influenza vaccine. In this work, a synthetic polyanhydride nanoparticle-based vaccine (or nanovaccine) platform for respiratory pathogens such as H5N1 was designed. In particular, the work focused on the design of a subunit vaccine based on antigens specific to H5N1 avian influenza.

Intranasal administration of vaccines can increase ...