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Theses/Dissertations

2013

Graduate Theses and Dissertations

Neurodegeneration

Neuroscience and Neurobiology

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Roles Of Manganese And Protein Kinase Signaling In Cell Culture And Animal Models Of Prion Disease, Dustin Paul Martin Jan 2013

Roles Of Manganese And Protein Kinase Signaling In Cell Culture And Animal Models Of Prion Disease, Dustin Paul Martin

Graduate Theses and Dissertations

Despite several decades of dedicated research by a diverse array of researchers from around the globe, the molecular mechanisms underlying neuronal loss during transmissible spongiform encephalopathy (TSE) remain to be elucidated. Additionally, the etiology of so-called "sporadic" cases of TSE, which represents the vast majority of cases in both humans and animals, remains unknown. Several recent advancements in the understanding of other protein misfolding neurodegenerative disorders including Alzheimer's Disease (AD), Parkinson's Disease (PD), Amyotrophic Lateral Sclerosi (ALS), and TSE have highlighted the similarities between disease etiopathogenesis which may broaden the diversity of potential future therapies. As our understanding ...