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Theses/Dissertations

2013

Graduate Theses and Dissertations

Assessment

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Full-Text Articles in Life Sciences

Characterization Of A Thiopurine S-Methyltransferase From Leptospira Borgpetersenii And Assessment Of Pre And Posttesting In The Middle School Classroom, Joy Marie Jackson Jan 2013

Characterization Of A Thiopurine S-Methyltransferase From Leptospira Borgpetersenii And Assessment Of Pre And Posttesting In The Middle School Classroom, Joy Marie Jackson

Graduate Theses and Dissertations

ABSTRACT

Spirochaete is a diverse phylum of Gram-negative bacteria that is located under the order, Spirochaetales, which is divided into three families: Spirochaetacea, Brachyspiraceae, and Leptospiraeae. Research was focused on the latter, specifically, the genus, Leptospira. Leptospira consists of many saprophytic, intermediate pathogenic, and pathogenic species, with L. interrogans (transmitted via contaminated water) and L. borpetersenii (acquired via host to host transmission) causing the majority of leptospirosis cases. To gain insight into the pathogenesis of Leptospira, a putative thiopurine S-methyltransferase (LBJ0800) was exploited. Because this gene is not present in any of the sequenced spirochetes, Brachyspira, Borrelia, Treponema, except Leptospira ...


Validation And Calibration Of Self-Report Methods: The Youth Activity Profile, Pedro Frederico De Saint-Maurice Maduro Jan 2013

Validation And Calibration Of Self-Report Methods: The Youth Activity Profile, Pedro Frederico De Saint-Maurice Maduro

Graduate Theses and Dissertations

The development of more accurate and precise methods of assessing physical activity behavior is an important public health research priority. Objective monitoring devices have advantages but the high cost and burden of data processing make them impractical for large scale applications. Subjective (survey-based) tools are inexpensive and easy to use but these suffer from questionable validity. Objective measures are often used to validate less accurate measures such as subjective instruments but this does not directly improve the accuracy or precision of the self-report instrument. The proposed line of research developed and tested a calibration equation approach that enabled data from ...