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Full-Text Articles in Life Sciences

Immunosenescence And Exercise-Mediated Modulation Of The Innate Immune Response To Influenza Infection In Mice, Shibani Naik Jan 2013

Immunosenescence And Exercise-Mediated Modulation Of The Innate Immune Response To Influenza Infection In Mice, Shibani Naik

Graduate Theses and Dissertations

Influenza virus is a negative sense, single stranded RNA virus that can cause severe respiratory tract infections in humans (along with other host animals such as horses, swine and poultry). Certain populations such as very young children, aged individuals, pregnant women and immunosuppressed individuals are more susceptible to influenza infections. One reason for the increased susceptibility to infection in the aged is a decreased efficacy of the seasonal influenza vaccine. As this particular section of our population continues to increase worldwide, research to improve vaccine efficacy is expanding along with efforts to identify lifestyle changes and interventions that can improve ...


Innate Immune Responses To Respiratory Syncytial Virus: Age-Associated Changes, Terianne Maiko Wong Jan 2013

Innate Immune Responses To Respiratory Syncytial Virus: Age-Associated Changes, Terianne Maiko Wong

Graduate Theses and Dissertations

Respiratory syncytial virus (RSV) infection causes ~64 million cases of respiratory disease and 200,000 deaths annually worldwide, yet there is no broadly effective prophylactic or treatment regimen. RSV can produce acute respiratory illness in patients of all ages but strikes the age extremes, infants and the elderly, with highest frequency presumably due to innate immune deficiencies. A higher morbidity and mortality has been reported for the elderly above 65 years of age, which has been attributed to immune senescence. Efforts to generate an effective vaccine have thus far been unsuccessful.

The innate immune system provides the first line of ...